LEADER 00954nam0-22003371i-450- 001 990008521260403321 005 20090119160302.0 010 $a0-8247-1611-6 035 $a000852126 035 $aFED01000852126 035 $a(Aleph)000852126FED01 035 $a000852126 100 $a20070604d1972----km-y0itay50------ba 101 0 $aeng 102 $aUS 200 1 $aHeat transfer in microelectronic equipment$ea practical guide$fJ. H. Seely , R. C. Chu 205 $a1.ed. 210 $aNew York$cDekker$d1972 215 $a350 p.$d24 cm 320 $aIncludes bibliographical references 610 0 $aMicroelettronica 676 $a621.3 700 1$aSeely,$bJohn H.$0301517 701 1$aChu,$bRichard C.$0301518 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990008521260403321 952 $a00 A476$b1908$fDETEC 959 $aDETEC 996 $aHeat transfer in microelectronic equipment$9732997 997 $aUNINA LEADER 03548nam 22005535 450 001 9911010533503321 005 20250618124739.0 010 $a3-031-93949-2 024 7 $a10.1007/978-3-031-93949-5 035 $a(CKB)39331566000041 035 $a(MiAaPQ)EBC32162269 035 $a(Au-PeEL)EBL32162269 035 $a(DE-He213)978-3-031-93949-5 035 $a(OCoLC)1525619271 035 $a(EXLCZ)9939331566000041 100 $a20250618d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTwenty-first Century Drug Discovery $ean Expanding Landscape /$fby Edward D. Zanders 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (365 pages) 311 08$a3-031-93948-4 327 $aPart I. Current State of Drug Discovery and Development -- Chapter 1. Introduction -- Chapter 2. Overview of Current Drug Discovery and Development -- Chapter 3. Computational Approaches to Drug Discovery -- Part II. Emerging Opportunities -- Chapter 4. Points of Scientific Impact -- Chapter 5. Hunting for Targets -- Chapter 6. Interventions -- Chapter 7. Development and Implementation. 330 $a?Twenty-first Century Drug Discovery ? an Expanding Landscape? follows on from the author?s previous book ?The Science and Business of Drug Discovery ? Demystifying the Jargon?, published by Springer as a second edition in 2020. While many of the key scientific and commercial features of drug discovery described in the latter are essentially unchanged since publication, the underlying science has advanced rapidly thereby presenting a broad landscape of opportunities for biopharmaceutical discovery in the twenty-first century and beyond. However, these wide-ranging and complex discovery opportunities are difficult to convey in a short period of time. This book overcomes the problem by giving readers time to study the relevant material at their leisure. Starting with a short overview of the current technical and commercial background to drug discovery and development, the book focuses on the discovery of novel targets and therapeutic agents. The latter are no longer just small molecules, but include engineered proteins, microbes and immune cells created as a result of advances in molecular cell biology and computational methods, among others. These discovery activities are presented as part of a group of ?systems? under the headings of Genetics, Cell Biology, Microbiome, Immune and Nervous Systems, none of which are mutually exclusive and all of which depend upon lab-based and computational technologies. These technologies are covered in some detail, highlighting in particular, single molecule and cell analysis, selective drug target degradation and machine learning. 606 $aBiotechnology 606 $aPharmaceutical chemistry 606 $aPharmacology 606 $aBiotechnology 606 $aPharmaceutics 606 $aPharmacology 615 0$aBiotechnology. 615 0$aPharmaceutical chemistry. 615 0$aPharmacology. 615 14$aBiotechnology. 615 24$aPharmaceutics. 615 24$aPharmacology. 676 $a660.6 700 $aZanders$b Edward D$0511858 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911010533503321 996 $aTwenty-First Century Drug Discovery$94397459 997 $aUNINA