LEADER 03732nam 22004933 450 001 9911009201403321 005 20240302060306.0 010 $a981-5165-67-4 035 $a(CKB)30557255800041 035 $a(MiAaPQ)EBC31187481 035 $a(Au-PeEL)EBL31187481 035 $a(Exl-AI)31187481 035 $a(OCoLC)1424745242 035 $a(DE-B1597)730021 035 $a(DE-B1597)9789815165678 035 $a(Perlego)4351608 035 $a(EXLCZ)9930557255800041 100 $a20240302d2024 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenome Editing in Bacteria (Part 1) 205 $a1st ed. 210 1$aSharjah :$cBentham Science Publishers,$d2024. 210 4$dİ2024. 215 $a1 online resource (201 pages) 311 08$a981-5165-68-2 327 $aCover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- List of Contributors -- Recent Advances in CRISPR-Cas Genome Engineering: An Overview -- Angelina Job Kolady1, Aritra Mukherjee1, Ranjith Kumavath1,2,*, Sarvepalli Vijay Kumar3 and Pasupuleti Sreenivasa Rao4,5,* -- INTRODUCTION -- GENOME EDITING -- GENOME EDITING TOOLS AND THEIR LIMITATIONS -- Restriction Enzymes (RE) -- Zinc Finger Nucleases (ZNFs) -- Transcription Activator Like Effector Nucleases -- Discovery and History -- Components of CRISPR-Cas -- Cas9 -- sgRNA and How to Design sgRNAs -- PAM Sequence -- Component CRISPR -- Component CRISPR (3C CRISPR) -- APPLICATION OF CRISPR -- Generation of Knockout -- Making Specific Modifications -- Combat Antimicrobial Resistance -- Genome Engineering in Agriculture -- Genome Engineering in Industrial Biotechnology -- FUTURE PERSPECTIVES OF CRISPR-CAS9$7Generated by AI. 330 $aThis reference is a comprehensive review of genome editing in bacteria. The multi-part book meticulously consolidates research findings and insights on the applications of bacteria across several industries, including food processing and pharmaceutical development. The book covers four overarching themes for readers: a historical perspective of genome editing, genome editing in probiotics, applications of genome editing in agricultural microbiology and genetic engineering in environmental microbiology. The editors have also compiled chapters that provide an in-depth analysis of gene regulation and metabolic engineering through genome editing tools for specific bacteria. Key topics in part 1: - An Overview of advances in CRISPR-CAS research - Applications of CRISPR/CAS9-based genome editing for industrial microorganisms - Gut microbiome modulation to address gut dysbiosis - Bifidobacterium genome editing for probiotic development and metabolic engineering. - Insights into the use of lactic acid bacteria as starter cultures in the food - Genome editing of vegetable-derived L. Plantarum - Genome editing in Bacillus Licheniformis Genome Editing in Bacteria is a definitive reference for scholars, researchers and industry professionals navigating the forefront of bacterial genomics. Readership Scholars and professionals interested in bacterial genomics. 606 $aGene editing$7Generated by AI 606 $aBacterial genetics$7Generated by AI 615 0$aGene editing 615 0$aBacterial genetics 700 $aHalami$b Prakash M$01827252 701 $aSundararaman$b Aravind$01827253 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911009201403321 996 $aGenome Editing in Bacteria (Part 1)$94395611 997 $aUNINA