LEADER 00644oas 2200169z- 450 001 9910302548103321 035 $a(CKB)3840000000207182 035 $a(EXLCZ)993840000000207182 100 $a20180319cuuuuuuuu -u- - 101 0 $aeng 200 00$aCompte rendu officiel des travaux de la Conférence économique réunie à Tananarive 210 $cImprimerie officielle 517 $aCompte rendu officiel des travaux de la Conférence économique réunie à Tananarive ... 906 $aJOURNAL 912 $a9910302548103321 996 $aCompte rendu officiel des travaux de la Conférence économique réunie à Tananarive$92976415 997 $aUNINA LEADER 04383nam 22005535 450 001 9911009144803321 005 20250610130301.0 010 $a981-9663-06-7 024 7 $a10.1007/978-981-96-6306-4 035 $a(CKB)39239992000041 035 $a(MiAaPQ)EBC32151029 035 $a(Au-PeEL)EBL32151029 035 $a(DE-He213)978-981-96-6306-4 035 $a(OCoLC)1525619122 035 $a(EXLCZ)9939239992000041 100 $a20250610d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aComplex Ophthalmic Dosage Forms: Advances in Biomedical Applications and Future Perspectives /$fedited by Neelesh Kumar Mehra 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (561 pages) 311 08$a981-9663-05-9 327 $aCHAPTER 1. Ocular drug delivery: introduction and fundamental concept -- CHAPTER 2. Eye: anatomy, physiology and disease -- CHAPTER 3. Drug delivery to the anterior segment of eye -- CHAPTER 4. Drug delivery to the posterior segment of eye -- CHAPTER 5. Fixed-dose combination approach in therapeutic delivery to the eye -- CHAPTER 6. Role of preservatives in ophthalmic products -- CHAPTER 7. Reverse engineering in complex/combination ophthalmic product -- CHAPTER 8. Role of quality by design (qbd) in ophthalmic products -- CHAPTER 9. Advances and opportunities of the novel functional nanocarriers -- CHAPTER 10. Safety and toxicities of nanocarriers in ophthalmic drug delivery system -- CHAPTER 11. Validation in sterile ophthalmic formulation -- CHAPTER 12. Packaging, container and closure of ophthalmic products -- CHAPTER 13. Regulatory perspectives in ophthalmic products -- CHAPTER 14. Polymeric microsponges for drug delivery to ocular candidiasis infections: preclinical and clinical evidences. 330 $aThis book, Complex Ophthalmic Dosage Forms: Advances in Biomedical Applications and Future Perspectives, offers a detailed overview of the latest innovations in ophthalmic drug delivery. Beginning with the fundamentals of ocular drug delivery systems and the anatomy of the eye, this book provides an exploration of drug delivery to both the anterior and posterior segments. A dedicated chapter on the fixed-dose combination approach examines its application in ocular diseases, highlighting both its therapeutic potential and associated challenges. Furthermore, the book delves into key aspects of ophthalmic product development, including reverse engineering, the role of preservatives, and the application of Quality by Design (QbD) principles. It includes discussions on the safety of nanoformulations, as well as an in-depth analysis of emerging nano-assisted platforms in ocular drug delivery, highlighting both opportunities and safety concerns. Recognizing the importance of packaging a dedicated chapter explores the critical role of sterility in ocular products, detailing sterility validation processes to ensure product safety and efficacy. This is followed by a thorough discussion on packaging, including the selection of appropriate containers and closure systems. Given that an optimized packaging system is essential for maintaining the stability, sterility, and overall quality of ophthalmic products, this section highlights key considerations in designing effective packaging solutions. Additionally, the book delves into regulatory considerations, challenges in clinical translation, and potential future developments that may redefine ophthalmic therapeutics.>

. 606 $aDrug delivery systems 606 $aOphthalmology 606 $aNanomedicine 606 $aDrug Delivery 606 $aOphthalmology 606 $aNanomedicine and Nanotoxicology 615 0$aDrug delivery systems. 615 0$aOphthalmology. 615 0$aNanomedicine. 615 14$aDrug Delivery. 615 24$aOphthalmology. 615 24$aNanomedicine and Nanotoxicology. 676 $a615.6 700 $aMehra$b Neelesh Kumar$01827618 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911009144803321 996 $aComplex Ophthalmic Dosage Forms: Advances in Biomedical Applications and Future Perspectives$94403624 997 $aUNINA