LEADER 03697nam 22004693 450 001 9911008941403321 005 20231223060236.0 010 $a9798891133389$b(electronic bk.) 010 $z9798891132665 035 $a(MiAaPQ)EBC30809009 035 $a(Au-PeEL)EBL30809009 035 $a(CKB)29440424900041 035 $a(OCoLC)1415896502 035 $a(EXLCZ)9929440424900041 100 $a20231223d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMethods for Laboratory Studies (Focusing Area 205 $a1st ed. 210 1$aNew York :$cNova Science Publishers, Incorporated,$d2023. 210 4$dİ2023. 215 $a1 online resource (392 pages) 225 1 $aResearch Advances in Communication Studies 311 08$aPrint version: Islam, Torequl Methods for Laboratory Studies (Focusing Area: Natural Product Drug Discovery) New York : Nova Science Publishers, Incorporated,c2023 9798891132665 327 $aNatural product drug discovery -- Introduction to non-clinical and pre-clinical studies -- Collection and extraction of materials -- Isolation of lead compounds -- Management of experimental animals -- Acute toxicity study and dose determination -- Administration route selection -- Nanotechnology : the interaction of metal ions with extract -- Biological activity studies -- Biopharmaceutical studies -- Toxicity analysis -- Computer-aided drug design (in silico study) -- Reagent preparation. 330 $a"In the dynamic field of drug discovery and development, non-clinical and pre-clinical studies are the foundation of success. With global relevance, "Methods for Laboratory Studies" is your comprehensive guide, offering vital insights for researchers, educators, and students worldwide. The book begins by highlighting the crucial role of non-clinical studies, conducted with strict adherence to Good Laboratory Practice (GLP) regulations. From experimental animals to diverse therapeutic goals, it ensures the highest safety and compliance standards. Dive deeper into early pre-clinical studies, the compass for Go/No-Go decisions. Here, you'll uncover the core elements of a new drug's journey, from pharmacokinetics to safety profiles, including toxicogenetics. Emphasizing GLP-compliant studies, like repeated dosage toxicity, genotoxicity, and safety pharmacology, it guarantees safe human exposure before human trials. Before entering human trials, meticulous completion of non-clinical and pre-clinical studies establishes a robust foundation for Investigational New Drug (IND) applications. Gain insights into the comprehensive research data package bridging the gap between animal and human trials as you turn the pages. After IND approval, additional GLP tests assess carcinogenicity, genotoxicity, chronic toxicity, and reproductive and developmental toxicity. "Methods for Laboratory Studies" isn't just a textbook; it's your gateway to mastering drug discovery. Whether you're a student, educator, or seasoned researcher, this book provides lucid, essential guidelines, empowering you to shape the future of pharmaceutical science"--$cProvided by publisher. 410 0$aResearch Advances in Communication Studies 606 $aDrug development 606 $aDrugs$xResearch$xMethodology 615 0$aDrug development. 615 0$aDrugs$xResearch$xMethodology. 676 $a615.1072/4 700 $aIslam$b Torequl$01826947 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9911008941403321 996 $aMethods for Laboratory Studies (Focusing Area$94395014 997 $aUNINA