LEADER 04733nam 2200589Ia 450 001 9911006612903321 005 20230721023152.0 010 $a1-61583-010-3 035 $a(CKB)1000000000810805 035 $a(EBL)3382401 035 $a(SSID)ssj0000072916 035 $a(PQKBManifestationID)11980440 035 $a(PQKBTitleCode)TC0000072916 035 $a(PQKBWorkID)10102935 035 $a(PQKB)11715070 035 $a(MiAaPQ)EBC3382401 035 $a(EXLCZ)991000000000810805 100 $a20081205d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRisk to the thyroid from ionizing radiation$b[electronic resource] 210 $aBethesda, Md. $cNational Council on Radiation Protection and Measurements$d2009 215 $a1 online resource (559 p.) 225 1 $aNCRP report ;$vno. 159 300 $aExtensive update and expansion of: Induction of thyroid cancer by ionizing radiation. c1985. 311 $a0-929600-97-5 320 $aIncludes bibliographical references and index. 327 $a""Preface""; ""Contents""; ""Executive Summary""; ""Purpose and Rationale""; ""Goals""; ""Synopsis of this Report""; ""Synopsis of this Reporta???s Conclusions and Recommendations""; ""Conclusions""; ""Recommendations""; ""1. Introduction""; ""1.1 Historic Overview""; ""1.1.1 Radioiodine Production and Use in the Study of Thyroid Physiology""; ""1.1.2 Use of Radioiodine in Medical Treatment""; ""1.1.3 Radiation Effects on the Thyroid Observed in Patients""; ""1.1.4 Radioiodine in the Environment""; ""1.2 Overview of this Report""; ""1.2.1 Thyroid and Parathyroid Glands"" 327 $a""1.2.2 Radiation Dosimetry and Dose Reconstruction""""1.2.3 Radiation Effects""; ""1.2.4 Radiation Risk for Thyroid Neoplasms""; ""1.2.5 Screening for Thyroid Disease Following Radiation Exposure""; ""1.2.6 Conclusions and Recommendations""; ""1.2.7 Appendices""; ""2. Thyroid and Parathyroid Glands""; ""2.1 Anatomy and Physiology""; ""2.1.1 Anatomy""; ""2.1.2 Physiology""; ""2.2 Diseases of the Thyroid and Parathyroid Glands""; ""2.2.1 Benign Thyroid Nodules""; ""2.2.2 Thyroid Cancer""; ""2.2.3 Functional Diseases""; ""2.3 Medical Uses of Radiation"" 327 $a""2.3.1 External Beam Radiation Therapy Exposures of the Thyroid""""2.3.2 Diagnostic Use of Radioactive Tracers in the Thyroid""; ""2.3.3 Radioactive Iodine Therapy""; ""2.3.4 Thyroid Dose from Radioactive Iodine""; ""2.4 Thyroid Genomics""; ""2.4.1 DNA Damage and Cellular Response""; ""2.4.2 Molecular Biology Techniques""; ""3. Radiation Dosimetry and Dose Reconstruction""; ""3.1 Specification of Dose in Principle and in Practice""; ""3.1.1 Specification of Dose: Ideal""; ""3.1.2 Specification of Dose: Practical""; ""3.2 External Dose""; ""3.2.1 Medical External Radiation Exposure"" 327 $a""3.2.2 External Radiation Exposure Associated with the Atomic Bombings of Hiroshima and Nagasaki""""3.3 Internal Dose""; ""3.3.1 Radioisotopes of Iodine""; ""3.3.2 Age-Dependent Thyroid Absorbed Doses from Radioisotopes of Iodine""; ""3.3.3 Environmental Dispersion of Radioiodine""; ""3.3.4 Potassium Iodide Blockade of Radioiodine Uptake in the Thyroid""; ""3.3.5 Limitations of the Radiobiological Significance of Iodine-129""; ""3.3.6 Spatial and Temporal Inhomogeneities in Intrathyroidal Radioiodine Distribution and Absorbed Dose"" 327 $a""3.3.7 Dose Assessment of Major Environmental Releases of Radioiodines""""3.4 Radiation Dosimetry in Specific Epidemiological Studies of Radiogenic Thyroid Disease""; ""4. Radiation Effects""; ""4.1 Animal Data""; ""4.1.1 Experiments with Rodents""; ""4.1.2 Experiments in Larger Animals""; ""4.1.3 Experiments to Determine Relative Biological Effectiveness""; ""4.2 Types of Epidemiologic Studies""; ""4.2.1 Cohort Studies""; ""4.2.2 Case-Control Studies""; ""4.2.3 Clinical Screening Studies""; ""4.2.4 Ecological (Aggregate) Studies"" 327 $a""4.3 Methodological Issues Regarding Studies of Radiation and Thyroid Tumors"" 410 0$aNCRP report ;$vno. 159. 606 $aThyroid gland$xCancer$xEtiology 606 $aIonizing radiation$xToxicology 606 $aIonizing radiation$xDose-response relationship 615 0$aThyroid gland$xCancer$xEtiology. 615 0$aIonizing radiation$xToxicology. 615 0$aIonizing radiation$xDose-response relationship. 676 $a362.196/9897 712 02$aNational Council on Radiation Protection and Measurements. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911006612903321 996 $aRisk to the thyroid from ionizing radiation$94392813 997 $aUNINA