LEADER 04256nam 22006375 450 001 9910845085503321 005 20240318130720.0 010 $a9789819991839 010 $a9819991838 024 7 $a10.1007/978-981-99-9183-9 035 $a(CKB)30977617300041 035 $a(MiAaPQ)EBC31222020 035 $a(Au-PeEL)EBL31222020 035 $a(DE-He213)978-981-99-9183-9 035 $a(OCoLC)1428258184 035 $a(EXLCZ)9930977617300041 100 $a20240318d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDrugs from Nature: Targets, Assay Systems and Leads /$fedited by Madhathilkovilakathu Haridas, Sabu Abdulhameed, Dileep Francis, Swaroop S Kumar 205 $a1st ed. 2024. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024. 215 $a1 online resource (572 pages) 311 08$a9789819991822 311 08$a981999182X 327 $aChapter 1. History of therapeutic discovery from natural sources -- Chapter 2. The process of drug development from natural sources -- Chapter 3. Ayurveda-inspired reverse pharmacology in drug discovery -- Chapter 4. Contemporary approaches in drug target identification and validation -- Chapter 5. Assay systems for identification of drug leads: contemporary approaches -- Chapter 6. Computational biology in lead identification and drug development -- Chapter 7. Physiology of inflammatory responses to external and autoimmune agents of diseases -- Chapter 8. Non-steroidal anti-inflammatory drug leads from natural sources -- Chapter 9. Mechanisms of side effects of non-steroidal anti-inflammatory drugs -- Chapter 10. Therapeutic targets in cancer -- Chapter 11. Anti-neoplastic drug leads from plants and microbes -- Chapter 12. Anti-fungal, anti-bacterial, and anti-parasitic therapeutics from natural sources -- Chapter 13. Anti-viral therapeutics from plants and microbes -- Chapter 14. Cardiovascular therapeutics from natural sources -- Chapter 15. Antidiabetics and antilipemics from nature -- Chapter 16. Therapeutic targets and drug leads for reproductive health -- Chapter 17. Drug leadsfor neuro-muscular disorders from natural sources. 330 $aThis book provides an overview of the drug discovery process from natural sources such as plants and microbes. While technological advances have streamlined the drug discovery process, enhancing the throughput and success rates, the structural features of natural products remain the primary reference for small-molecule drug discovery. Focusing on the drug targets blocked/altered by natural/nature-inspired molecules, it covers how potential drug leads are screened and identified using appropriate assay systems, and the current status of drugs identified using such approaches. State-of-the-art approaches in target identification, assay development, and lead identification have also been discussed in detail. Other topics included are targets and leads in inflammation, cancer, reproductive medicine, cardiovascular and neuromuscular ailments, and infectious diseases as well as the challenges in translating drug leads into clinically viable drugs. This volume serves as a handbook for researchers in phytochemistry and drug discovery, and as a reference for researchers and students of applied biology. 606 $aPharmacology 606 $aBiotechnology 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aPharmacology 606 $aBiotechnology 606 $aBiomedical Research 615 0$aPharmacology. 615 0$aBiotechnology. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aPharmacology. 615 24$aBiotechnology. 615 24$aBiomedical Research. 676 $a615 700 $aHaridas$b Madhathilkovilakathu$01733743 701 $aAbdulhameed$b Sabu$01733744 701 $aFrancis$b Dileep$01733745 701 $aKumar$b Swaroop S$01733746 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910845085503321 996 $aDrugs from Nature: Targets, Assay Systems and Leads$94149625 997 $aUNINA LEADER 04907nam 2200697Ia 450 001 9911004895503321 005 20240925174155.0 010 $a9786611905583 010 $a9781281905581 010 $a1281905585 010 $a9781933995953 010 $a1933995955 035 $a(CKB)2430000000015842 035 $a(EBL)362208 035 $a(OCoLC)297820028 035 $a(SSID)ssj0000307916 035 $a(PQKBManifestationID)11225277 035 $a(PQKBTitleCode)TC0000307916 035 $a(PQKBWorkID)10250480 035 $a(PQKB)10072533 035 $a(MiAaPQ)EBC362208 035 $a(MiAaPQ)EBC686332 035 $a(Au-PeEL)EBL362208 035 $a(CaPaEBR)ebr10379694 035 $a(CaONFJC)MIL190558 035 $a(Au-PeEL)EBL686332 035 $a(Perlego)532577 035 $a(EXLCZ)992430000000015842 100 $a20080710d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aReflections of a political economist $eselected articles on government policies and political processes /$fWilliam A. Niskanen 205 $a1st ed. 210 $aWashington, D.C. $cCato Institute$d2008 215 $a1 online resource (378 p.) 300 $aDescription based upon print version of record. 311 08$a9781933995205 311 08$a1933995203 320 $aIncludes bibliographical references and index. 327 $aTable of Contents; Introduction: On Maturing as a Political Economist; Part I: Policy Analysis; 1. Oil Is Not Worth a War; 2. R&D and Economic Growth: Cautionary Thoughts; 3. Too Much, Too Soon: Is a Global Warming Treaty a Rush to Judgment; 4. Next Steps toward Health Policy Reform; 5. The Economic Basis for Military Capability; 6. Creating Good Jobs and Good Wages; 7. Should the Ex-Im Bank Be Retired; 8. On the Death of the Phillips Curve; 9. The Economic Burden of Taxation; 10. Increasing Individual Responsibility Would Improve Retirement Security; 11. An Unnecessary War Is an Unjust War 327 $a12. Major Policy Lessons from the Corporate Scandals13. An Unconventional Perspective on the Greenspan Record; 14. The Several Costs of Responding to the Threat of Terrorism; 15. The Failure to ""Starve the Beast""; Part 11: Public Choice; 16. Autocratic, Democrati; 17. A Vote for Perot Was a Vote for the Status Quo; 18. On the Constitution of a Compound Republic; 19. Bureaucracy: A Final Perspective; 20. Bringing Power to Knowledge: Choosing Policies to Use Decentralized Knowledge; 21. On the Origin and Identification of Government Failures; 22. The Intellectual Case for a Free Market Economy 327 $a23. U.S. Elections Are Increasingly Biased against Moderates24. Advice from a Friendly American on the Proposed Constitution for the European Union; 25. A Case for Divided Government; 26. Alternative Political and Economic Futures for Europe; 27. On Wisconsin: Some Friendly Constitutional Advice; 28. A Reformulation of Voting Theory; Part III: Book Reviews; 29. Pop Internationalism; 30. Everything for Sale: The Virtues and Limits of Markets; 31. Perspectives on Public Choice: A Handbook; 32. Power and Prosperity: Outgrowing Communist and Capitalist Dictatorships 327 $a33. In Defense of Free Capital Markets: The Case Against a New International Financial Architecture34. Virginia Political Economy: The Selected Works of Gordon Tullock; 35. Pay Without Performance: The Unfulfilled Promise of Executive Compensation; 36. The Market for Virtue: The Potential and Limits of Corporate Social Responsibility; 37. Why I, Too, Am not a Conservative: The Normative Vision of Classical Liberalism; 38. The Age of Turbulence: Adventures in a New World; Part IV: Personal Reflections; 39. A Reflection on the Major Developments in the World, 1951-2000 327 $a40. Policy Proposals from the Libertarian Right41. A Personal Reflection on the Trinity; Index; About the Author; Cato Institute 330 $aAcclaimed economist and Cato chairman William A. Niskanen illustrates how economic incentives significantly aid in the creation of successful policies and applies his sharply focused economic perspective to such topics as unemployment, election law, and the economics of war and peace. This practical approach toward economic policy generates surprising results and offers suggestions to avoid common pitfalls of government policymaking. 606 $aEconomics$zUnited States$y21st century 607 $aUnited States$xEconomic policy$y2001-2009 607 $aUnited States$xEconomic conditions$y2001-2009 615 0$aEconomics 676 $a330.973 700 $aNiskanen$b William A.$f1933-2011.$0119330 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911004895503321 996 $aReflections of a political economist$94388110 997 $aUNINA