LEADER 05488nam 2200625 a 450 001 9911004742003321 005 20230725031408.0 010 $a1-61344-055-3 010 $a1-4416-9390-4 035 $a(CKB)2670000000092018 035 $a(EBL)3382412 035 $a(SSID)ssj0000540223 035 $a(PQKBManifestationID)12202586 035 $a(PQKBTitleCode)TC0000540223 035 $a(PQKBWorkID)10580967 035 $a(PQKB)11124645 035 $a(MiAaPQ)EBC3382412 035 $a(BIP)34621990 035 $a(EXLCZ)992670000000092018 100 $a20110314d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPotential impact of individual genetic susceptibility and previous radiation exposure on radiation risk for astronauts $erecommendations of the National Council on Radiation Protection and Measurements 210 $aBethesda, Md. $cNational Council on Radiation Protection and Measurements$dc2011 215 $a1 online resource (195 p.) 225 0 $aNCRP report Potential impact of individual genetic susceptibility and previous radiation exposure on radiation risk for astronauts. 225 0$aNCRP report ;$vno. 167 300 $a"April 28, 2010." 311 08$a0-9823843-5-1 320 $aIncludes bibliographical references (p.134-161). 327 $a""Cover""; ""Preface""; ""Contents""; ""Executive Summary""; ""1. Introduction""; ""1.1 Purpose of the Report""; ""1.2 Contents of the Report""; ""1.2.1 Introduction""; ""1.2.2 Radiation Exposures Received Over Lifetimes of Astronauts""; ""1.2.3 Biology Pertinent to Variations in Individual Susceptibility with Respect to Radiation Risks for Astronauts""; ""1.2.4 Predicting Cancer Risks from Previous Radiation or Chemotherapy Treatments""; ""1.2.5 Basis for Considering Medical Treatment, Disease, and Genetic Background in the NASA Occupational Radiation Protection Program"" 327 $a""1.2.6 Regulatory and Statutory Issues""""1.2.7 Ethical Issues of Radiation Exposure, Genetic Background, and Astronaut Selection for Space Missions""; ""1.2.8 Background Issues, Conclusions, and Recommendations""; ""2. Radiation Exposures Received Over Lifetimes of Astronauts""; ""2.1 Radiation Protection Quantities""; ""2.1.1 Absorbed Dose""; ""2.1.2 Categories of Radiation-Induced Biological Effects""; ""2.1.3 Radiation Protection Quantities for Deterministic Effects""; ""2.1.4 Radiation Protection Quantities for Stochastic Effects""; ""2.2 Sources of Exposure to Ionizing Radiation"" 327 $a""2.2.1 Radiation Exposures Received by the U.S. Population""""2.2.2 Medical Exposures""; ""2.2.3 Space Radiation Exposures During Previous Space Missions""; ""2.2.4 Radiation Exposures During Jet Aircraft Flights""; ""2.3 Key Issues""; ""3. Biology Pertinent to Variations in Individual Susceptibility with Respect to Radiation Risks for Astronauts""; ""3.1 Overview""; ""3.2 Average Risks for Radiation-Induced Diseases of Concern for Astronauts""; ""3.2.1 Cancer Risk""; ""3.2.2 Heritable Risk""; ""3.2.3 Embryo and Fetal Risk""; ""3.2.4 Other Risks Associated with Radiation Exposure"" 327 $a""3.3 Evidence of Variation in Radiation Sensitivity and Susceptibility to Effects of Principal Concern""""3.3.1 Evidence of Genetic Variation in Radiation Sensitivity from Cellular and Molecular Research""; ""3.3.2 Evidence for Variation in Radiation Sensitivity from Animal Studies""; ""3.3.3 Evidence of Variation in Radiation Sensitivity from Human Studies""; ""3.3.4 Genetic Sources of Variation in Cancer Susceptibility""; ""3.3.5 Impact of Genetic Variation on Radiation Risk""; ""3.3.6 Congenital Sources of Variation in Cancer Susceptibility"" 327 $a""3.3.7 Special Considerations for Astronauts""""3.3.8 Key Issues""; ""4. Predicting Cancer Risks from Previous Radiation or Chemotherapy Treatments""; ""4.1 Introduction""; ""4.2 Second Cancers After Radiation Therapy""; ""4.2.1 Carcinogenic Effects of Radiation""; ""4.2.2 Factors Affecting Risk of Second Malignancy""; ""4.3 Risk of Radiation-Induced Malignancies""; ""4.3.1 Radiation-Induced Leukemia""; ""4.3.2 Radiation-Induced Solid Tumors""; ""4.4 Characteristics of Medical Radiation Exposures""; ""4.4.1 Radiation Dose""; ""4.4.2 Radiation Treatment Planning and Delivery"" 327 $a""4.5 Interactions Between Chemotherapy and Radiation: Impact on Cancer Risk"" 330 $aThis Report was prepared to evaluate the potential impact of individual genetic susceptibility and previous radiation exposures on radiation associated health risks for astronauts during their lifetimes following space missions. The Report also evaluates whether either of these factors needs to be included in the radiation protection program for astronauts. 606 $aRadiation injuries$xGenetic aspects 606 $aAstronauts$xHealth risk assessment 606 $aSpace flight$xHealth aspects 615 0$aRadiation injuries$xGenetic aspects. 615 0$aAstronauts$xHealth risk assessment. 615 0$aSpace flight$xHealth aspects. 676 $a362.196/9897 712 02$aNational Council on Radiation Protection and Measurements. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911004742003321 996 $aPotential impact of individual genetic susceptibility and previous radiation exposure on radiation risk for astronauts$94390870 997 $aUNINA