LEADER 05293nam 22007815 450 001 9910999779703321 005 20250430130234.0 010 $a3-031-82990-5 024 7 $a10.1007/978-3-031-82990-1 035 $a(CKB)38672100100041 035 $a(DE-He213)978-3-031-82990-1 035 $a(MiAaPQ)EBC32063924 035 $a(Au-PeEL)EBL32063924 035 $a(OCoLC)1524422455 035 $a(EXLCZ)9938672100100041 100 $a20250430d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Male Reproductive Medicine $eBiology and Clinical Perspectives /$fedited by C. Yan Cheng, Fei Sun 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (VIII, 442 p. 25 illus., 24 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1469 311 08$a3-031-82989-1 327 $aCurrent and Future Applications of Artificial Intelligence to Diagnose and Treat Male Infertility.-Immune Regulation in the Testis and Epididymis -- Innate Antiviral Defense of the Male Reproductive System -- Basal and Immune Cells of the Epididymis: An Electron Microscopy View of Their Association -- Molecular Pathways Implicated in the Differentiation and Function of Epididymal Basal cells -- Effect of Endocrine Disruptors on Testicular Function -- Unveiling the research void: exploring the reproductive effects of PFAS compounds on male health -- Computational Approaches in Spatial Transcriptomics for the Study of Mammalian Spermatogenesis -- scRNA-Seq-based transcriptome profiling and relevant bioinformatics approaches to uncover novel insights in studying human spermatogenesis -- A Comprehensive Bibliometric Analysis of Orchitis Research from 1980 to 2023 -- Non-Hormonal Contraception: Current and Emerging Targets -- Proteostasis as a Sentry for Sperm Quality and Male Fertility -- Sperm DNA Fragmentation and Fertility -- The Biology and Regulation of Spermatogonial Stem Cells in the Niche -- The interacting Fat1 and Dchs planar cell polarity (PCP) proteins supported by Fjx1 serve as heterodimeric intercellular bridges crucial to support spermatogenesis -- Extracellular Vesicles in the Aging Male Reproductive System: Progresses and Perspectives -- Intraflagellar transport (IFT) and sperm formation -- Microtubule-associated proteins (MAPs) are multi-functional cytoskeletal proteins in the testis that regulate spermatogenesis -- Testis is a sanctuary site for HIV-1. 330 $aThis book bridges the gap of basic research in male reproductive biology and its relationship to clinical studies. Bringing together a group of senior investigators with decades of experience in research and clinical investigation and keen interest in collaboration between the two areas, this book provides a balanced treatment of technical and basic research insights and cutting-edge findings, while introducing new ideas for clinical applications of this research. Section I is devoted to clinical aspects including testis biology, prostate biology, and spermatogenesis by senior investigators of male infertility treatment, particularly non-obstructive azoospermia. Section II presents the latest findings in male reproductive biology from a basic research perspective, as well as covering cutting-edge technology such as scRNA-Seq, scATAC-Seq, DNA chromatic accessibility and organization studies, genetic models, cell biology, molecular biology, and biochemistry on testis biology, and spermatogenesis. This book offers not only a cohesive summary of new findings and concepts in basic and clinical male reproductive research, it analyzes and assembles these concepts into a roadmap for the next decade of translational research, bringing lab discoveries to the bedside. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1469 606 $aReproduction 606 $aPhysiology 606 $aReproductive health 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aToxicology 606 $aEndocrine glands 606 $aEndocrinology 606 $aReproductive Physiology 606 $aReproductive Medicine 606 $aBiomedical Research 606 $aToxicology 606 $aEndocrine System 606 $aEndocrinology 615 0$aReproduction. 615 0$aPhysiology. 615 0$aReproductive health. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aToxicology. 615 0$aEndocrine glands. 615 0$aEndocrinology. 615 14$aReproductive Physiology. 615 24$aReproductive Medicine. 615 24$aBiomedical Research. 615 24$aToxicology. 615 24$aEndocrine System. 615 24$aEndocrinology. 676 $a571.8 702 $aCheng$b C. Yan$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSun$b Fei$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910999779703321 996 $aMolecular Male Reproductive Medicine$94374970 997 $aUNINA