LEADER 05220nam 22007335 450 001 9910999696203321 005 20250417130257.0 010 $a981-9634-56-3 024 7 $a10.1007/978-981-96-3456-9 035 $a(CKB)38484835200041 035 $a(DE-He213)978-981-96-3456-9 035 $a(MiAaPQ)EBC32013216 035 $a(Au-PeEL)EBL32013216 035 $a(OCoLC)1515506699 035 $a(EXLCZ)9938484835200041 100 $a20250417d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRNA-Based Cancer Therapeutics $eTechniques, Applications and Challenges in Prognosis /$fedited by Narendra Kumar Sharma, Tikam Chand Dakal, Pawan Kumar Maurya, Gulshan Wadhwa 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (XIII, 297 p. 26 illus., 24 illus. in color.) 311 08$a981-9634-55-5 327 $aChapter 1. An Introduction to RNA-based Therapeutics -- Chapter 2. Application Of Advance Crispr/Cas-9 And Other Genomic Tools In RNA Based Therapeutics -- Chapter 3. Applications of Advance ASOs, RNA Mimics and Others in RNA-based Therapeutics -- Chapter 4. Global changes in genome and proteome by mi-RNAs in cancers and other diseases -- Chapter 5. Short- and long-non-coding RNA causes global alterations in the genome and proteome in cancer and other disorders -- Chapter 6. Predictive and Prognostic Relevance of miRNAs in Cancers and Other Diseases -- Chapter 7. Diagnostic, Prognostic, and Predictive Short and Long Non-coding RNA Biomarkers in Cancer -- Chapter 8. RNA-Based Molecular Applications as Tool Compounds in Diagnostic and Clinical Settings -- Chapter 9. Clinical trials on RNA-based therapeutics for the treatment of infectious diseases and other pathologies -- Chapter 10. Challenges and Opportunities Used in RNA-based Therapeutics -- Chapter 11. Pragmatic Clinical Methods, Tools and Amplification techniques used in RNA-based diagnostic applications -- Chapter 12. Practical Clinical Approaches Used in RNA-based Therapeutics. 330 $aBy consistently dedicating efforts to multi-omic and other high-throughput technologies, it is expected that RNA therapies will have a vital role in future personalized medicine approaches for cancer therapy. Within this framework, analyzing the genetic sequence of a patient's tumor would allow for the detection of crucial driver mutations or changes that cause resistance to drugs. These mutations may then be targeted with RNA therapies that are particularly designed to treat those particular variations. Recent clinical trials have shown that RNA-based therapies hold great potential for treating several illnesses. However, further investigations are required to improve the delivery materials and understand the RNA alterations linked to these groundbreaking drugs, in order to facilitate their integration into clinical practice. Ideally, these therapeutic substances would be specifically administered to the tumor cells of interest using a targeted delivery agent. In this hypothetical situation, the choice of medications for cancer patients would differ depending on the precise abnormalities detected in each person, potentially including inhibitors that target circuits known to cause resistance to treatments. However, doing a more thorough assessment of the challenges and potential benefits discussed in each chapter would enhance the capacity to critically analyze this rapidly evolving field of therapies. This book largely examines the latest developments and clinical studies related to RNA-based medications, while also examining the challenges and future possibilities linked with them. This method shows potential for greatly improving the prognosis of cancer patients. 606 $aRNA interference 606 $aCancer$xGenetic aspects 606 $aMedical genetics 606 $aCancer$xTreatment 606 $aCancer 606 $aOncology 606 $aRNA Interference 606 $aCancer Genetics and Genomics 606 $aClinical Genetics 606 $aCancer Therapy 606 $aCancer Biology 606 $aOncology 615 0$aRNA interference. 615 0$aCancer$xGenetic aspects. 615 0$aMedical genetics. 615 0$aCancer$xTreatment. 615 0$aCancer. 615 0$aOncology. 615 14$aRNA Interference. 615 24$aCancer Genetics and Genomics. 615 24$aClinical Genetics. 615 24$aCancer Therapy. 615 24$aCancer Biology. 615 24$aOncology. 676 $a572.88 702 $aS?arma?$b Narendrakuma?ra$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aChand Dakal$b Tikam$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMaurya$b Pawan Kumar$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWadhwa$b Gulshan$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910999696203321 996 $aRNA-Based Cancer Therapeutics$94374945 997 $aUNINA