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010   $a981-9633-64-8
024 7 $a10.1007/978-981-96-3364-7
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035   $a(Au-PeEL)EBL32028970
035   $a(OCoLC)1517424959
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100   $a20250424d2025      u|         0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMolecular Theory of Fluctuation in Life Phenomena /$fby Fumio Hirata
205   $a1st ed. 2025.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025.
215   $a1 online resource (X, 146 p. 31 illus., 19 illus. in color.) 
311 08$a981-9633-63-X 
327   $aIntroduction -- Phenomenological description -- Statistical mechanics of molecular liquids -- Irreversible statistical mechanics of molecular liquids -- Conformational and density fluctuation in biomolecular system -- Chemical reactions of biomolecules in solutions -- Transitions among equilibrium states driven by fluctuations.
330   $aThis book describes molecular processes taking place in living cells, in which ?water? or ?solvation? play essential roles. The molecular processes include conformational stability, fluctuation, relaxation, self-organization, molecular recognition, and chemical reactions. In all those processes, so-called solvation free-energy, and its first and second derivatives with respect to the atomic coordinates of biomolecules play key roles. Such derivatives of the free energy may not be calculated by any method of molecular simulation, because the calculation requires an analytical formula of the solvation free energy as a function of the atomic coordinates of a biomolecule. In this book, the theory is applied to analyze phenomena closely related to the conformational and density fluctuation of biomolecular systems, including the entropy and spectroscopy of both biomolecules and solvents. The theory is further developed to give microscopic expressions to the well-regarded phenomenological theories of chemical reactions, including the Michaelis?Menten theory of the enzymatic reaction, and the theory of the electron-transfer reaction by R. Marcus. Also clarified in the book is physical basis of Anfinsen?s hypothesis concerning the protein folding. This book is beneficial for graduate students and researchers in the field of life science and technology, especially for those studying pharmaceutical design and biomimetic technology such as artificial enzymes.
606   $aChemistry, Physical and theoretical
606   $aPhysical biochemistry
606   $aBiophysics
606   $aBiomolecules
606   $aBiology$xTechnique
606   $aEnzymology
606   $aTheoretical Chemistry
606   $aBiophysical Chemistry
606   $aMolecular Biophysics
606   $aBiophysical Methods
606   $aEnzymology
615  0$aChemistry, Physical and theoretical.
615  0$aPhysical biochemistry.
615  0$aBiophysics.
615  0$aBiomolecules.
615  0$aBiology$xTechnique.
615  0$aEnzymology.
615 14$aTheoretical Chemistry.
615 24$aBiophysical Chemistry.
615 24$aMolecular Biophysics.
615 24$aBiophysical Methods.
615 24$aEnzymology.
676   $a541.2
700   $aHirata$b Fumio$4aut$4http://id.loc.gov/vocabulary/relators/aut$01817225
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910999677703321
996   $aMolecular Theory of Fluctuation in Life Phenomena$94374779
997   $aUNINA