LEADER 04721nam 22006735 450 001 9910996492603321 005 20250413023611.0 010 $a3-031-81743-5 024 7 $a10.1007/978-3-031-81743-4 035 $a(CKB)38429189000041 035 $a(DE-He213)978-3-031-81743-4 035 $a(MiAaPQ)EBC32007545 035 $a(Au-PeEL)EBL32007545 035 $a(EXLCZ)9938429189000041 100 $a20250413d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aIntegration and Bridging of Multiscale Bioengineering Designs and Tissue Biomechanics /$fedited by Jun Liao, Joyce Y. Wong 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (IX, 561 p. 100 illus. in color.) 311 08$a3-031-81742-7 327 $aMechanical and structural contributions of elastin and collagen fibers to interlamellar bonding in the arterial wall -- Tissue engineering of vascular constructs -- Engineering the multiscale complexity of vascular networks -- Epicardial layer and endocardial layer as mechanical protective interfaces for cardiac function -- Dynamic remodeling in live cardiomyocytes -- Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture -- Multiscale light-sheet for rapid assessing of cardiac architecture and function -- Spongiosa as an integrative interface for aortic valve trilayered structure -- Advances in experimental and computational biomechanics of the tricuspid heart valve -- Heterogeneous and multiscale mechanical behavior of aortic valve leaflets -- Multi-scale approach to investigate mechanically-induced changes in tricuspid valve anterior leaflet microstructure -- Multiscale Mechanical Considerations for Polymeric Heart Valve Development -- The stabilization of elastin network in heart valve tissue engineering -- Glutaraldehyde cross-linked mitral valves -- Contribution of glycosaminoglycans to tendon mechanical properties -- Interfibrillar shear stress as the loading mechanism of collagen fibrils in tendon -- Tendon-to-bone Interface: structural-mechanical integration of enthesis -- Hierarchical collagen fiber formation for functional tendon, ligament, and meniscus replacement -- Tissue-engineered collagen graft using a novel load-bearing suture technique -- Tendon/Ligament repair with biomimetic and smart cellular constructs -- Tendon/Ligament-Like tissue via three-dimensional cyclic mechanical stretch culture system. 330 $aThis book covers up-to-date knowledge of how designs found in nature use tissue hierarchies to achieve optimal functions, and how these principles are applied in bioengineering. The hierarchy-based multiscale approach has the potential to drive novel biomaterial designs, advance tissue engineering and regeneration, assist in tissue-function integration, improve high-fidelity computational modeling aided by machine learning, and enhance the development of innovative characterization tools and methodologies. This book presents the latest high-impact research achievements in bioengineered and natural hierarchical systems within a clinical context. Our aim is two-fold: (i) to emphasize the importance of integrating and bridging bioengineering designs at various tissue hierarchical levels and (ii) to foster dialogue and collaboration among bioengineers, biomechanists, and clinicians. . 606 $aBiomedical engineering 606 $aRegenerative medicine 606 $aBiomechanics 606 $aBiomaterials 606 $aTissues 606 $aChemistry 606 $aBiomedical Engineering and Bioengineering 606 $aRegenerative Medicine and Tissue Engineering 606 $aBiomechanics 606 $aBiomaterials 606 $aTissues 615 0$aBiomedical engineering. 615 0$aRegenerative medicine. 615 0$aBiomechanics. 615 0$aBiomaterials. 615 0$aTissues. 615 0$aChemistry. 615 14$aBiomedical Engineering and Bioengineering. 615 24$aRegenerative Medicine and Tissue Engineering. 615 24$aBiomechanics. 615 24$aBiomaterials. 615 24$aTissues. 676 $a610.28 702 $aLiao$b Jun$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWong$b Joyce Y$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910996492603321 996 $aIntegration and Bridging of Multiscale Bioengineering Designs and Tissue Biomechanics$94370014 997 $aUNINA