LEADER 01694nas 2200445-a 450 001 9910993976503321 005 20240911213022.0 011 $a2523-0980 035 $a(CKB)110978966559774 035 $a(CONSER)---68006139- 035 $a(DE-599)ZDB3214730-2 035 $a(EXLCZ)99110978966559774 100 $a20760204a19679999 -a- - 101 0 $aeng 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEthiopian journal of education 210 $aAddis Ababa $cFaculty of Education, Haile Sellassie I University 215 $a1 online resource 300 $aRefereed/Peer-reviewed 311 08$aPrint version: Ethiopian journal of education. (DLC) 68006139 (OCoLC)1967727 0425-4414 606 $aEducation$zEthiopia$vPeriodicals 606 $aEducation$2fast$3(OCoLC)fst00902499 607 $aEthiopia$2fast$1https://id.oclc.org/worldcat/entity/E39PBJrm4PwJjwQwWdt7T4CJDq 608 $aPeriodicals.$2fast 615 0$aEducation 615 7$aEducation. 676 $a370/.963 712 02$aHaile Sellassie I University.$bFaculty of Education. 712 02$aHaile Sellassie I University.$bFaculty of Education.$bResearch Centre. 712 02$aNational University (Addis Ababa, Ethiopia).$bFaculty of Education.$bResearch Center. 712 02$aAddis Ababa University.$bFaculty of Education.$bResearch Center. 712 02$aAddis Ababa University.$bEducational Research Center. 712 02$aAddis Ababa University.$bInstitute of Educational Research. 906 $aJOURNAL 912 $a9910993976503321 920 $aexl_impl conversion 996 $aEthiopian journal of education$91320064 997 $aUNINA LEADER 02979nam 2200457z- 450 001 9910136805303321 005 20210211 035 $a(CKB)3710000000631089 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55673 035 $a(oapen)doab55673 035 $a(EXLCZ)993710000000631089 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aParkinson's Disease Cell Vulnerability and Disease Progression 210 $cFrontiers Media SA$d2015 215 $a1 online resource (194 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-676-3 330 $aParkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease. 606 $aNeurosciences$2bicssc 610 $aCell vulnerability 610 $aDopamine 610 $aDopaminergic Neurons 610 $ahabitual behavior 610 $aMitochondria 610 $aParkinson's Disease 610 $aStriatum 610 $aSubstantia Nigra 610 $asynuclein 615 7$aNeurosciences 700 $aJose A. Obeso$4auth$01328826 702 $aJavier Blesa$4auth 702 $aJose L. Lanciego$4auth 906 $aBOOK 912 $a9910136805303321 996 $aParkinson's Disease Cell Vulnerability and Disease Progression$93039002 997 $aUNINA