LEADER 04873nam 22007095 450 001 9910993942903321 005 20250715211925.0 010 $a9783031829987 010 $a3031829980 024 7 $a10.1007/978-3-031-82998-7 035 $a(CKB)38337753500041 035 $a(DE-He213)978-3-031-82998-7 035 $a(MiAaPQ)EBC32003984 035 $a(Au-PeEL)EBL32003984 035 $a(EXLCZ)9938337753500041 100 $a20250408d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aZero ? Much to Do About Nothing? /$fby Jim E. Riviere 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (XXV, 203 p. 288 illus., 8 illus. in color.) 311 08$a9783031829970 311 08$a3031829972 327 $aIntroduction and Overview -- Philosophy -- History of Zero as a Number -- Zero in Mathematics and Statistics -- Physics -- Chemistry and Limits of Analytical Detection and Quantitation -- Biology and Pharmacology -- Toxicology Dose Makes the Difference -- Cancer -- Food Safety -- Doping and Performance Drugs, Substances of Abuse, Death, Finance and Other Encounters with Zero -- Summary and Personal Conclusions. 330 $aZero ? Much to Do About Nothing? is a thought-provoking work that delves into the complexities of defining ?zero? in various fields, from mathematics and physics to pharmacology and food safety. Drawing on his extensive experience in teaching, research and managing a USDA-supported chemical food safety program, Jim E. Riviere provides readers with practical examples and case studies that highlight the challenges of defining ?zero? in different contexts across a wide range of fields. In his four decades of university teaching, doing research in pharmacology, toxicology, biomathematics and nanoscience, Dr. Riviere has repeatedly encountered the concept of ?zero? and the broad parameters utilized to achieve a proper definition. "Zero? enters when discussions concern defining "nothing", "negligible", "very small", "below level of detection", "absence of effect" or "safe". This renders the term ?zero? incredibly confusing to scientists, practitioners and regulators. This book explores the origin of the concept of ?zero? in mathematics, physics, chemistry and statistics and how these concepts migrated to fields such as pharmacology, toxicology, cancer research and food safety, as well as to the legal profession in the form of regulatory science and policy. Specific chapters deal with the application of ?zero? to these distinct fields. The main focus throughout the book is to illustrate how important context is to the definition of ?zero?. This has assumed greater relevance today with the advent of nanoscience where ?small? implies different physical and chemical behavior and the use of artificial Intelligence to analyze vast troves of data from the web. The goal of the book is to provide much-needed clarity about "zero" and break down the many issues preventing it. Riviere expertly explains how the concept of ?zero? is essential to a wide range of issues, from defining negligible amounts of a substance to determining the safety of a product or process. He shows how the term ?zero? can have different meanings in different fields and how this can lead to confusion and misunderstandings among scientists, practitioners and regulators. Whether you're working in Food Safety, Chemistry, Pharmacology, Mathematics, Physics or beyond, Zero ? Much to Do About Nothing? is a relatable book that will deepen your understanding of the concept of ?zero? and its diverse applications. 606 $aFood$xSafety measures 606 $aFood science 606 $aChemistry 606 $aPharmacology 606 $aMathematics 606 $aPhysics$xPhilosophy 606 $aFood Safety 606 $aFood Science 606 $aChemistry 606 $aPharmacology 606 $aGeneral Mathematics 606 $aPhilosophy of Physics 615 0$aFood$xSafety measures. 615 0$aFood science. 615 0$aChemistry. 615 0$aPharmacology. 615 0$aMathematics. 615 0$aPhysics$xPhilosophy. 615 14$aFood Safety. 615 24$aFood Science. 615 24$aChemistry. 615 24$aPharmacology. 615 24$aGeneral Mathematics. 615 24$aPhilosophy of Physics. 676 $a363.1926 700 $aRiviere$b J. Edmond$g(Jim Edmond),$4aut$4http://id.loc.gov/vocabulary/relators/aut$00 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910993942903321 996 $aZero ? Much to Do About Nothing$94375454 997 $aUNINA