LEADER 03471nam 22007335 450 001 9910254250203321 005 20200629184819.0 010 $a3-319-26305-6 024 7 $a10.1007/978-3-319-26305-2 035 $a(CKB)3710000000628333 035 $a(EBL)4471820 035 $a(SSID)ssj0001665819 035 $a(PQKBManifestationID)16455382 035 $a(PQKBTitleCode)TC0001665819 035 $a(PQKBWorkID)15000382 035 $a(PQKB)10883360 035 $a(DE-He213)978-3-319-26305-2 035 $a(MiAaPQ)EBC4471820 035 $a(PPN)193445514 035 $a(EXLCZ)993710000000628333 100 $a20160331d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAdvanced Hybrid and Electric Vehicles $eSystem Optimization and Vehicle Integration /$fedited by Michael Nikowitz 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (230 p.) 225 1 $aLecture Notes in Mobility,$x2196-5544 300 $aDescription based upon print version of record. 311 $a3-319-26304-8 320 $aIncludes bibliographical references at the end of each chapters. 327 $aIntroduction -- OEM and Industry Review -- International Deployment and Demonstration Projects -- Advanced Vehicle Performance Assessment -- System Optimization and Vehicle Interaction -- Final Results and Recommendations. 330 $aThis contributed volume contains the results of the research program ?Agreement for Hybrid and Electric Vehicles?, funded by the International Energy Agency. The topical focus lies on technology options for the system optimization of hybrid and electric vehicle components and drive train configurations which enhance the energy efficiency of the vehicle. The approach to the topic is genuinely interdisciplinary, covering insights from fields. The target audience primarily comprises researchers and industry experts in the field of automotive engineering, but the book may also be beneficial for graduate students. 410 0$aLecture Notes in Mobility,$x2196-5544 606 $aAutomotive engineering 606 $aTransportation 606 $aSustainable development 606 $aManagement 606 $aIndustrial management 606 $aAutomotive Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T17047 606 $aTransportation$3https://scigraph.springernature.com/ontologies/product-market-codes/119000 606 $aSustainable Development$3https://scigraph.springernature.com/ontologies/product-market-codes/U34000 606 $aInnovation/Technology Management$3https://scigraph.springernature.com/ontologies/product-market-codes/518000 615 0$aAutomotive engineering. 615 0$aTransportation. 615 0$aSustainable development. 615 0$aManagement. 615 0$aIndustrial management. 615 14$aAutomotive Engineering. 615 24$aTransportation. 615 24$aSustainable Development. 615 24$aInnovation/Technology Management. 676 $a629.2293 702 $aNikowitz$b Michael$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254250203321 996 $aAdvanced Hybrid and Electric Vehicles$91539988 997 $aUNINA LEADER 04115nam 22005655 450 001 9910992791903321 005 20250730215012.0 010 $a981-9627-63-X 024 7 $a10.1007/978-981-96-2763-9 035 $a(CKB)38165287900041 035 $a(DE-He213)978-981-96-2763-9 035 $a(MiAaPQ)EBC31979874 035 $a(Au-PeEL)EBL31979874 035 $a(EXLCZ)9938165287900041 100 $a20250328d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCell Signaling Pathways and Their Therapeutic Implication in Cancers /$fedited by Muneeb U. Rehman, Mosin Saleem Khan 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (XX, 435 p. 55 illus., 46 illus. in color.) 311 08$a981-9627-62-1 327 $aChapter 1. An Introduction to Cell Signalling pathways and their Dysregulation in cancer -- Chapter 2. Involvement of Mitogen activated protein (MAP) Kinase pathway in the etiopathogenesis of cancer and its role in cancer therapeutics -- Chapter 3. Association of PI3K/AKT/mTOR pathway with cancer and its therapeutic implications -- Chapter 4. Role and therapeutic implication of Hedgehog signalling pathway in cancer -- Chapter 5. Hippo LATS pathway in cancer and its role as a potential target for anti-cancer drugs -- Chapter 6. Role and therapeutic implication of Notch signalling pathway in cancer -- Chapter 7. Role and therapeutic implication of Wnt signalling pathway in cancer -- Chapter 8. Involvement and therapeutic implication of JAK-STAT pathway in cancer -- Chapter 9. Role of cAMP?PKA?CREB signalling pathway in cancer -- Chapter 10. Role and therapeutic implications of vitamin D signalling pathway in cancer -- Chapter 11. TGF-? signalling pathway in cancer and its therapeutic role -- Chapter 12. Role of signaling pathways regulating cell cycle progression in cancer -- Chapter 13. Role of signaling pathways regulating genomic stability in cancer. 330 $aThis book discusses different signaling pathways involved in tumor development and progression. It discusses the pathways that allow tumor cells to proliferate, survive, and invade other tissues. Further, the book reviews the signal transduction regulating phagocytosis, production of cytokines, cell division, and differentiation. It elucidates the dysregulation of cellular signal transduction induced by the genetic and epigenetic changes that drive cancer and enumerates the signaling network encompassing the extracellular matrix, blood vessels, and the immune system. Additionally, the book provides mechanistic insights into inhibitors of the receptor tyrosine kinases, BRAF, EGFR, and ALK that improve clinical response and increase the survival of patients with cancer. The book covers the signal transduction pathways that regulate cell cycle progression and genomic stability, providing a mechanistic understanding of the major checkpoint pathways, and reviewing their diagnostic and therapeutic potential. This volume is essential reading for researchers to understand the therapeutic potential of important signaling molecules against cancer. 606 $aCancer 606 $aCell division 606 $aCancer$xGenetic aspects 606 $aCancer Biology 606 $aCell Division 606 $aCancer Genetics and Genomics 615 0$aCancer. 615 0$aCell division. 615 0$aCancer$xGenetic aspects. 615 14$aCancer Biology. 615 24$aCell Division. 615 24$aCancer Genetics and Genomics. 676 $a571.978 676 $a616.994 702 $aRehman$b Muneeb U$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKhan$b Mosin Saleem$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910992791903321 996 $aCell Signaling Pathways and Their Therapeutic Implication in Cancers$94349111 997 $aUNINA