LEADER 03535nam 22006375 450 001 9910988284803321 005 20251217234425.0 010 $a981-9610-16-8 024 7 $a10.1007/978-981-96-1016-7 035 $a(CKB)38111214100041 035 $a(DE-He213)978-981-96-1016-7 035 $a(MiAaPQ)EBC31975403 035 $a(Au-PeEL)EBL31975403 035 $a(EXLCZ)9938111214100041 100 $a20250326d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHypoxia and Tumor Microenvironment $eImplications for Cancer Therapy /$fedited by Sukhes Mukherjee, Jagat Rakesh Kanwar 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (XIV, 236 p. 45 illus. in color.) 311 08$a981-9610-15-X 327 $a-- Chapter 1: Tumor Hypoxia An Introduction -- Chapter 2: Hypoxia and tumor immunity -- Chapter 3: Incipient Role of Non coding RNAs in different types of cancer hypoxia -- Chapter 4: Hypoxia induced DNA damage response and genomic instability dictate cancer treatment response -- Chapter 5: Metabolic regulation of CAR T cell function by hypoxic tumor -- Chapter 6: Emerging roles of non coding RNAs in tumor hypoxia -- Chapter 7: Regulation of Angiogenesis by Cancer Hypoxia and Role of Hypoxia Inducible Factors with Therapeutic Paradigm -- Chapter 8: Hypoxia and Regulation of Cancer Cell Stemness -- Chapter 9: Hypoxia-Inducible Factors: Regulation and Therapeutic Potential in Cancer: Artificial Intelligence in Precision Medicine -- Chapter 10: Strategic application of bio reductive metalloprodrugs for cancer cell-selective anticancer therapy -- Chapter 11: Hypoxia Inducible Factors Regulation and Therapeutic Potential. 330 $aThis book provides a comprehensive overview of the hypoxic tumor microenvironment and its impact on various aspects of cancer biology, including DNA damage response, genome instability, tumor immunity, non-coding RNA regulation, metabolic regulation of CAR-T cell function, and angiogenesis. It explores the regulation and therapeutic potential of hypoxia-inducible factors, as well as strategies to improve cancer immunotherapy by targeting the hypoxic tumor microenvironment. This book is a valuable resource for students, researchers, and Medical science professionals interested in understanding the complex interplay between hypoxia and cancer biology. 606 $aCancer 606 $aCancer$xTreatment 606 $aTumors$xImmunological aspects 606 $aTumor Microenvironment 606 $aNeoplasms$xtherapy 606 $aTumor Hypoxia 606 $aCancers 606 $aCancer Therapy 606 $aCancer Biology 615 0$aCancer. 615 0$aCancer$xTreatment. 615 0$aTumors$xImmunological aspects. 615 2$aTumor Microenvironment. 615 2$aNeoplasms$xtherapy. 615 2$aTumor Hypoxia. 615 14$aCancers. 615 24$aCancer Therapy. 615 24$aCancer Biology. 676 $a571.978 676 $a616.994 702 $aMukherjee$b Sukhes$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKanwar$b Jagat Rakesh$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910988284803321 996 $aHypoxia and Tumor Microenvironment$94349731 997 $aUNINA