LEADER 01377nam2-2200421li-450- 001 990000256050203316 005 20091109095626.0 035 $a0025605 035 $aUSA010025605 035 $a(ALEPH)000025605USA01 035 $a0025605 100 $a19940307d1971----km-y0itay50------ba20001109d--------km-y0itay0103----ba 101 $aeng 102 $aUS 105 $a||||||||001yy 200 1 $aIntroduction to fourier analysis on euclidean spaces$fElias M. Stein, Guido Weiss 210 $aPrinceton$cPrinceton university press$dcopyr. 1971 215 $aX, 297 p.$d23cm 225 2$aPrinceton mathematical series$v32 410 1$1001000333101$12001$aPrinceton mathematical series$v32 606 0$aAnalisi di Fourier 676 $a515.723 700 1$aSTEIN,$bElias M.$041144 701 1$aWEISS,$bGuido$045074 801 0$aIT$bsalbc$gISBD 912 $a990000256050203316 951 $a510 PM 32 (A)$b5986/CBS$c510$d00112166 951 $a510 PM 32 (B)$b2793/CBS$c510$d00112167 959 $aBK 969 $aSCI 979 $c19940307 979 $c20001110$lUSA01$h1715 979 $c20020403$lUSA01$h1634 979 $aPATRY$b90$c20040406$lUSA01$h1618 979 $aRSIAV7$b90$c20090423$lUSA01$h1020 979 $aRSIAV6$b90$c20091109$lUSA01$h0956 996 $aIntroduction to fourier analysis on euclidean spaces$9882269 997 $aUNISA LEADER 03758nam 22006615 450 001 9910986128903321 005 20250311115259.0 010 $a9783031779213 024 7 $a10.1007/978-3-031-77921-3 035 $a(CKB)37836718600041 035 $a(MiAaPQ)EBC31957519 035 $a(Au-PeEL)EBL31957519 035 $a(DE-He213)978-3-031-77921-3 035 $a(OCoLC)1506874799 035 $a(EXLCZ)9937836718600041 100 $a20250311d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aThymus Transcriptome and Cell Biology /$fedited by Geraldo A. Passos, Daniella Arêas Mendes-da-Cruz, Wilson Savino 205 $a2nd ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (488 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1471 311 08$a9783031779206 327 $aChapter 1 - History of the Thymus -- Chapter 2 -Thymus Ontogeny and Development -- Chapter 3 -The ins and outs of thymic epithelial -- Chapter 4 - From T-Lineage Specification to Intrathymic Maturation -- Chapter 5 - Intrathymic cell migration -- Chapter 6 -Thymic crosstalk -- Chapter 7 - The Autoimmune Regulator (AIRE) Gene -- Chapter 8 - Aire mutations and Autoimmune Diseases -- Chapter 9 -The thymus as a mirror -- Chapter 10 -The CRISPR-Cas9 system -- Chapter 11 -Age-related thymic involution -- Chapter 12 - T-cell Recovery After Autologous. 330 $aThis volume focuses on a challenging field in biomedicine: the genetic control of central immune tolerance. The thymus gland is a lymphoid organ implicated in T cells' maturation, differentiation, and selection. Its function is associated with the control of immune homeostasis in the body, establishing central immune tolerance, and preventing the onset of autoimmune diseases. This book focuses on thymus development, their cellular components and their respective function, and the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus and the Autoimmune regulator (Aire) gene. Chapters also explore the mutations in the Aire gene, manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. This new edition includes two new chapters devoted to the genome editing of the Aire gene through Crispr-Cas9 system, and thymic involution.All chapters have been updated to reflect the latest research in the field. . 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1471 606 $aBioinformatics 606 $aMedical genetics 606 $aEndocrinology 606 $aCytology 606 $aComputational and Systems Biology 606 $aMedical Genetics 606 $aEndocrinology 606 $aCell Biology 615 0$aBioinformatics. 615 0$aMedical genetics. 615 0$aEndocrinology. 615 0$aCytology. 615 14$aComputational and Systems Biology. 615 24$aMedical Genetics. 615 24$aEndocrinology. 615 24$aCell Biology. 676 $a570.285 676 $a570.113 700 $aPassos$b Geraldo A$01379197 701 $aMendes-da-Cruz$b Daniella Arêas$01790647 701 $aSavino$b Wilson$01297647 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910986128903321 996 $aThymus Transcriptome and Cell Biology$94327381 997 $aUNINA