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024 7 $a10.1007/978-3-031-77921-3
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035   $a(DE-He213)978-3-031-77921-3
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101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aThymus Transcriptome and Cell Biology /$fedited by Geraldo A. Passos, Daniella Arêas Mendes-da-Cruz, Wilson Savino
205   $a2nd ed. 2025.
210  1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025.
215   $a1 online resource (488 pages)
225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1471
311 08$a9783031779206 
327   $aChapter 1 - History of the Thymus -- Chapter 2 -Thymus Ontogeny and Development -- Chapter 3 -The ins and outs of thymic epithelial -- Chapter 4 - From T-Lineage Specification to Intrathymic Maturation -- Chapter 5 - Intrathymic cell migration -- Chapter 6 -Thymic crosstalk -- Chapter 7 - The Autoimmune Regulator (AIRE) Gene -- Chapter 8 - Aire mutations and Autoimmune Diseases -- Chapter 9 -The thymus as a mirror -- Chapter 10 -The CRISPR-Cas9 system -- Chapter 11 -Age-related thymic involution -- Chapter 12 - T-cell Recovery After Autologous.
330   $aThis volume focuses on a challenging field in biomedicine: the genetic control of central immune tolerance. The thymus gland is a lymphoid organ implicated in T cells' maturation, differentiation, and selection. Its function is associated with the control of immune homeostasis in the body, establishing central immune tolerance, and preventing the onset of autoimmune diseases. This book focuses on thymus development, their cellular components and their respective function, and the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus and the Autoimmune regulator (Aire) gene. Chapters also explore the mutations in the Aire gene, manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. This new edition includes two new chapters devoted to the genome editing of the Aire gene through Crispr-Cas9 system, and thymic involution.All chapters have been updated to reflect the latest research in the field. .
410  0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1471
606   $aBioinformatics
606   $aMedical genetics
606   $aEndocrinology
606   $aCytology
606   $aComputational and Systems Biology
606   $aMedical Genetics
606   $aEndocrinology
606   $aCell Biology
615  0$aBioinformatics.
615  0$aMedical genetics.
615  0$aEndocrinology.
615  0$aCytology.
615 14$aComputational and Systems Biology.
615 24$aMedical Genetics.
615 24$aEndocrinology.
615 24$aCell Biology.
676   $a570.285
676   $a570.113
700   $aPassos$b Geraldo A$01379197
701   $aMendes-da-Cruz$b Daniella Arêas$01790647
701   $aSavino$b W$g(Wilson)$01297647
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910986128903321
996   $aThymus Transcriptome and Cell Biology$94327381
997   $aUNINA