LEADER 04830nam 22007575 450 001 9910983380603321 005 20250207115227.0 010 $a9789819610419 010 $a9819610419 024 7 $a10.1007/978-981-96-1041-9 035 $a(MiAaPQ)EBC31900184 035 $a(Au-PeEL)EBL31900184 035 $a(CKB)37491513300041 035 $a(DE-He213)978-981-96-1041-9 035 $a(OCoLC)1498869086 035 $a(EXLCZ)9937491513300041 100 $a20250207d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular Senescence, Age-Related Disorders, and Emerging Treatments /$fedited by Imteyaz Qamar, Pawan Kumar Maurya 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (451 pages) 311 08$a9789819610402 311 08$a9819610400 327 $aChapter 1. Introduction to Cellular Senescence and Ageing -- Chapter 2. The Epigenetic Landscape of Cellular Senescence -- Chapter 3. Senescence and the Microenvironment -- Chapter 4. Critical Signaling Pathways Activating Cellular Senescence and Immortalization -- Chapter 5. The Emerging Role of T-cell Senescence Markers in Humans -- Chapter 6. Cellular Senescence and Stem Cell Exhaustion -- Chapter 7. Senescence and Neurodegenerative Disorders: Beyond Alzheimer's and Parkinson's -- Chapter 8. Pancreatic ?-Cell Senescence: A Contributor to Type 2 Diabetes -- Chapter 9. Cellular Senescence and Cardiovascular Ageing -- Chapter 10. Cellular Senescence and Cancer -- Chapter 11. Cellular Senescence and Lung Diseases: From COPD to Fibrosis -- Chapter 12. Senescence and Sexual Aging: Implications for Men and Women -- Chapter 13. Senescence as a Therapeutic Target -- Chapter 14. Anti-Aging Therapeutics: From Nutraceuticals to Pharmaceuticals -- Chapter 15. Ethical Considerations and Societal Implications. 330 $aThis book provides a comprehensive understanding of cellular senescence, which is a phenomenon, characterized by the irreversible arrest of cell growth and is accompanied by the secretion of various factors, collectively known as the senescence-associated secretory phenotype (SASP), which can have detrimental effects on surrounding cells and tissues. The book examines the role of cellular senescence as a driver of age-related disorders such as cancer, neurodegenerative diseases, cardiovascular conditions, and metabolic disorders. By elucidating the molecular mechanisms involved, the book aims to deepen our understanding of these complex diseases and identify potential therapeutic targets. The book also explores cutting-edge therapeutic modalities that target cellular senescence, ranging from small molecule inhibitors to gene-based therapies and regenerative approaches. The distinctive features of the book include its comprehensive approach, integration of multidisciplinary expertise, in-depth exploration of therapeutic modalities, evidence-based insights supported by scientific research, and a translational focus. The interdisciplinary collaboration ensures a holistic understanding of the subject matter, fostering a synergistic approach to addressing age-related disorders. The book not only discusses the potential of emerging therapeutic modalities but also emphasizes practical implications, providing a bridge between research and real-world applications. This book is useful to researchers, scientists, and academics in the fields of molecular biology, genetics, gerontology, and cellular biology. 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aClinical biochemistry 606 $aNeuropharmacology 606 $aCytology 606 $aAging 606 $aNeurophysiology 606 $aNeurons 606 $aBiomedical Research 606 $aMedical Biochemistry 606 $aNeuropharmacology 606 $aCellular Senescence 606 $aCellular Neuroscience 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aClinical biochemistry. 615 0$aNeuropharmacology. 615 0$aCytology. 615 0$aAging. 615 0$aNeurophysiology. 615 0$aNeurons. 615 14$aBiomedical Research. 615 24$aMedical Biochemistry. 615 24$aNeuropharmacology. 615 24$aCellular Senescence. 615 24$aCellular Neuroscience. 676 $a610.72 700 $aQamar$b Imteyaz$01784333 701 $aMaurya$b Pawan Kumar$01784334 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910983380603321 996 $aCellular Senescence, Age-Related Disorders, and Emerging Treatments$94315995 997 $aUNINA