LEADER 01808oas 22006613a 450 001 9910144752903321 005 20260218112137.0 035 $a(DE-599)ZDB2502273-8 035 $a(OCoLC)1083154292 035 $a(CONSER)cn2002700340 035 $a(CKB)991042735647204 035 $a(DE-599)2502273-8 035 $a(EXLCZ)99991042735647204 100 $a20020107a19969999 ua b 101 0 $afre 135 $aurcn||||||||| 181 $ctxt$2rdacontent/fre 182 $cc$2rdamedia/fre 200 10$aRapport annuel /$fConseil canadien des normes 210 $aOttawa $cLe Conceil$d[1996?]- 300 $aDisponible sur le site Web du Programme des services de de?po?t du Gouvernement du Canada. 300 $aCertaines livr. comportent aussi un titre distinct. 311 08$a1701-4255 531 0 $aRapp. annu. - Cons. can. normes 606 $aStandardization$zCanada 606 $aNormalisation$zCanada 606 $aStandardization$2fast 607 $aCanada$2fast$1https://id.oclc.org/worldcat/entity/E39PBJkMHVW4rfVXPrhVP4VwG3 608 $aPeriodicals$2fast 615 0$aStandardization 615 6$aNormalisation 615 7$aStandardization 676 $a352.8/3/097105 686 $acci1icc$2lacc 686 $acoll11$2lacc 686 $acoll14$2lacc 686 $acoll29$2lacc 686 $acoll108$2lacc 801 0$bNLC 801 1$bNLC 801 2$bOCLCO 801 2$bOCLCQ 801 2$bOCLCA 801 2$bCNMBL 801 2$bAU@ 801 2$bOCLCF 801 2$bOCLCO 801 2$bOCLCA 801 2$bOCLCQ 801 2$bOCLCO 801 2$bOCL 801 2$bOCLCL 801 2$bNLC 801 2$bOCLCL 906 $aJOURNAL 912 $a9910144752903321 996 $aRapport annuel -$94309483 997 $aUNINA LEADER 04882nam 22007695 450 001 9910983380603321 005 20251116214104.0 010 $a9789819610419 010 $a9819610419 024 7 $a10.1007/978-981-96-1041-9 035 $a(MiAaPQ)EBC31900184 035 $a(Au-PeEL)EBL31900184 035 $a(CKB)37491513300041 035 $a(DE-He213)978-981-96-1041-9 035 $a(OCoLC)1498869086 035 $a(EXLCZ)9937491513300041 100 $a20250207d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular Senescence, Age-Related Disorders, and Emerging Treatments /$fedited by Imteyaz Qamar, Pawan Kumar Maurya 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (451 pages) 225 0 $aBiomedical and Life Sciences Series 311 08$a9789819610402 311 08$a9819610400 327 $aChapter 1. Introduction to Cellular Senescence and Ageing -- Chapter 2. The Epigenetic Landscape of Cellular Senescence -- Chapter 3. Senescence and the Microenvironment -- Chapter 4. Critical Signaling Pathways Activating Cellular Senescence and Immortalization -- Chapter 5. The Emerging Role of T-cell Senescence Markers in Humans -- Chapter 6. Cellular Senescence and Stem Cell Exhaustion -- Chapter 7. Senescence and Neurodegenerative Disorders: Beyond Alzheimer's and Parkinson's -- Chapter 8. Pancreatic ?-Cell Senescence: A Contributor to Type 2 Diabetes -- Chapter 9. Cellular Senescence and Cardiovascular Ageing -- Chapter 10. Cellular Senescence and Cancer -- Chapter 11. Cellular Senescence and Lung Diseases: From COPD to Fibrosis -- Chapter 12. Senescence and Sexual Aging: Implications for Men and Women -- Chapter 13. Senescence as a Therapeutic Target -- Chapter 14. Anti-Aging Therapeutics: From Nutraceuticals to Pharmaceuticals -- Chapter 15. Ethical Considerations and Societal Implications. 330 $aThis book provides a comprehensive understanding of cellular senescence, which is a phenomenon, characterized by the irreversible arrest of cell growth and is accompanied by the secretion of various factors, collectively known as the senescence-associated secretory phenotype (SASP), which can have detrimental effects on surrounding cells and tissues. The book examines the role of cellular senescence as a driver of age-related disorders such as cancer, neurodegenerative diseases, cardiovascular conditions, and metabolic disorders. By elucidating the molecular mechanisms involved, the book aims to deepen our understanding of these complex diseases and identify potential therapeutic targets. The book also explores cutting-edge therapeutic modalities that target cellular senescence, ranging from small molecule inhibitors to gene-based therapies and regenerative approaches. The distinctive features of the book include its comprehensive approach, integration of multidisciplinary expertise, in-depth exploration of therapeutic modalities, evidence-based insights supported by scientific research, and a translational focus. The interdisciplinary collaboration ensures a holistic understanding of the subject matter, fostering a synergistic approach to addressing age-related disorders. The book not only discusses the potential of emerging therapeutic modalities but also emphasizes practical implications, providing a bridge between research and real-world applications. This book is useful to researchers, scientists, and academics in the fields of molecular biology, genetics, gerontology, and cellular biology. 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aClinical biochemistry 606 $aNeuropharmacology 606 $aCytology 606 $aAging 606 $aNeurophysiology 606 $aNeurons 606 $aBiomedical Research 606 $aMedical Biochemistry 606 $aNeuropharmacology 606 $aCellular Senescence 606 $aCellular Neuroscience 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aClinical biochemistry. 615 0$aNeuropharmacology. 615 0$aCytology. 615 0$aAging. 615 0$aNeurophysiology. 615 0$aNeurons. 615 14$aBiomedical Research. 615 24$aMedical Biochemistry. 615 24$aNeuropharmacology. 615 24$aCellular Senescence. 615 24$aCellular Neuroscience. 676 $a610.72 700 $aQamar$b Imteyaz$01784333 701 $aMaurya$b Pawan Kumar$01784334 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910983380603321 996 $aCellular Senescence, Age-Related Disorders, and Emerging Treatments$94315995 997 $aUNINA