LEADER 03208nam 22005895 450 001 9910983355503321 005 20250131115237.0 010 $a9783031786112 010 $a3031786114 024 7 $a10.1007/978-3-031-78611-2 035 $a(CKB)37407192900041 035 $a(DE-He213)978-3-031-78611-2 035 $a(MiAaPQ)EBC31897195 035 $a(Au-PeEL)EBL31897195 035 $a(OCoLC)1499718811 035 $a(EXLCZ)9937407192900041 100 $a20250131d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenetic Models of Down Syndrome /$fedited by Bing Ye, Roger Reeves 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (VII, 274 p. 33 illus., 30 illus. in color.) 311 08$a9783031786105 311 08$a3031786106 327 $aChapter 1: Introduction -- Chapter 2 : Rodent Models of Down Syndrome I: Mouse & Rat -- Chapter 3: Rodent Models of Down Syndrome II: Mouse -- Chapter 4: Rodent Models of Down Syndrome III: Mouse -- Chapter 5: Modeling Down Syndrome in C. elegans -- Chapter 6: Modeling Down Syndrome in Drosophila -- Chapter 7: Zebrafish Models of Down Syndrome -- Chapter 8: Using Human Brain organoids to Study Down Syndrome -- Chapter 9: Cellular Models: Stem Cells and other Cellular Models.-Chapter 10: Conclusions and Perspectives. 330 $aDown syndrome is a textbook example of a chromosomal disorder and is common, occurring in 1 in 700 live births in the US. While there are many books previously published on the genetics of Down syndrome, and many studies in diverse species, this is the first book of its kind on the research models for Down syndrome that covers animal models. This book offers an in-depth introduction and discussion of the genetic models of down syndrome across diverse species, including rodents, zebrafish, drosophila, and human organoids. Authors use a cross-cutting approach to compare the strengths and weaknesses of each model system, explore how to use model organisms to study human diseases, and capture the status of the field. This book is a useful resource for biomedical researchers and students interested in using model systems to study Down syndrome and learn about Down syndrome and other chromosomal disorders. 606 $aGenetics$xResearch 606 $aGenetics 606 $aDevelopmental biology 606 $aGenetics Research 606 $aGenetics 606 $aDevelopmental Biology and Stem Cells 615 0$aGenetics$xResearch. 615 0$aGenetics. 615 0$aDevelopmental biology. 615 14$aGenetics Research. 615 24$aGenetics. 615 24$aDevelopmental Biology and Stem Cells. 676 $a616.042072 702 $aYe$b Bing$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aReeves$b Roger$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910983355503321 996 $aGenetic Models of Down Syndrome$94316882 997 $aUNINA