LEADER 03836 am 22003013u 450 001 9910346038103321 005 20190409 010 $a9781928396574 024 7 $a10.4102/aosis.2018.BK71 035 $a(CKB)4920000000093745 035 $a(OAPEN)1004783 035 $a(EXLCZ)994920000000093745 100 $a20190409d|||| uy 101 0 $aeng 135 $auuuuu---auuuu 200 14$aThe e-Government Development Discourse 210 $aDurbanville$cAOSIS$d2018 215 $a1 online resource (326) 311 $a1-928396-57-7 330 $aresearch agenda for e-Government. When e-Government was first conceived, it was designed upon basic technologies where the emphasis was only on the simple display of government information for citizens to read. Nowadays, e-Government design comprises many complicated modules such as upload and download consoles, two-way interaction consoles between citizens and government agents, integrated government business processes presenting the whole of government, and it does not depend solely on technology. The complexity of e-Government has now evolved to include political, cultural, economic, social and technical dimensions. Bringing all these difficult aspects together is so complicated that it needs carefully planned strategies informed by local contextual characteristics. Rather than giving formulaic definitions and conceptual standpoints on many aspects of e-Government, as is the case in many e-Government publications, this book will explore the frontiers of global knowledge value chains by discussing current and future dimensions of e-Government. For example, the book discusses the concept of data governance by exploring how actual opening up of government data can be achieved, especially in a developing world context. Further, the book posits that opening government data should be followed by the opening up of government business processes in order to peddle the concept of accountability and responsiveness. Much text on data governance has concentrated on articulating the basic definitions surrounding this concept. Another very important topic explored in this book is regarding how the concept of decolonisation can be extended to e-Government by providing practical examples as to how researchers in the developing world can contribute to the advancement of e-Government as a scientific field of enquiry and guide its implementation, thereof. Decolonisation is advocated for in e-Government research so that there is a balance in the inclusion of the Afrocentric knowledge into e-Government advancement other than over-reliance on the Euro-, Asia- and America-centric knowledge value chains (Mbembe 2015). As e-Government is a very expensive undertaking, the issue of funding has excluded African countries and a majority of the developing world from implementing e-Government. Despite funding being a critical cornerstone of e-Government development, there is a dearth of information on this topic. Therefore, this book provides a chapter which discusses traditional and innovative ways of funding e-Government design and implementation which can go a long way in improving e-Government penetration into the developing world. Further, the book explores how intelligent e-Government applications can be designed, especially in resource-constrained countries. A couple of emerging technology innovations such as fog computing and intelligent information technology are explored within the realm of e-Government design. 606 $aPolitics & government$2bicssc 606 $aInformation technology: general issues$2bicssc 615 7$aPolitics & government 615 7$aInformation technology: general issues 906 $aBOOK 912 $a9910346038103321 996 $aThe e-Government Development Discourse$92235172 997 $aUNINA LEADER 03260nam 22006015 450 001 9910983355503321 005 20251116214039.0 010 $a9783031786112 010 $a3031786114 024 7 $a10.1007/978-3-031-78611-2 035 $a(CKB)37407192900041 035 $a(DE-He213)978-3-031-78611-2 035 $a(MiAaPQ)EBC31897195 035 $a(Au-PeEL)EBL31897195 035 $a(OCoLC)1499718811 035 $a(EXLCZ)9937407192900041 100 $a20250131d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenetic Models of Down Syndrome /$fedited by Bing Ye, Roger Reeves 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (VII, 274 p. 33 illus., 30 illus. in color.) 225 0 $aBiomedical and Life Sciences Series 311 08$a9783031786105 311 08$a3031786106 327 $aChapter 1: Introduction -- Chapter 2 : Rodent Models of Down Syndrome I: Mouse & Rat -- Chapter 3: Rodent Models of Down Syndrome II: Mouse -- Chapter 4: Rodent Models of Down Syndrome III: Mouse -- Chapter 5: Modeling Down Syndrome in C. elegans -- Chapter 6: Modeling Down Syndrome in Drosophila -- Chapter 7: Zebrafish Models of Down Syndrome -- Chapter 8: Using Human Brain organoids to Study Down Syndrome -- Chapter 9: Cellular Models: Stem Cells and other Cellular Models.-Chapter 10: Conclusions and Perspectives. 330 $aDown syndrome is a textbook example of a chromosomal disorder and is common, occurring in 1 in 700 live births in the US. While there are many books previously published on the genetics of Down syndrome, and many studies in diverse species, this is the first book of its kind on the research models for Down syndrome that covers animal models. This book offers an in-depth introduction and discussion of the genetic models of down syndrome across diverse species, including rodents, zebrafish, drosophila, and human organoids. Authors use a cross-cutting approach to compare the strengths and weaknesses of each model system, explore how to use model organisms to study human diseases, and capture the status of the field. This book is a useful resource for biomedical researchers and students interested in using model systems to study Down syndrome and learn about Down syndrome and other chromosomal disorders. 606 $aGenetics$xResearch 606 $aGenetics 606 $aDevelopmental biology 606 $aGenetics Research 606 $aGenetics 606 $aDevelopmental Biology and Stem Cells 615 0$aGenetics$xResearch. 615 0$aGenetics. 615 0$aDevelopmental biology. 615 14$aGenetics Research. 615 24$aGenetics. 615 24$aDevelopmental Biology and Stem Cells. 676 $a616.042072 702 $aYe$b Bing$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aReeves$b Roger$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910983355503321 996 $aGenetic Models of Down Syndrome$94316882 997 $aUNINA