LEADER 04850nam 2200529 450 001 9910795156603321 005 20231110225516.0 010 $a1-78491-824-5 035 $a(CKB)4900000000578544 035 $a(MiAaPQ)EBC6985948 035 $a(Au-PeEL)EBL6985948 035 $a(EXLCZ)994900000000578544 100 $a20230119d2018 uy 0 101 0 $aita 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDinamiche insediative nelle campagne dell'Italia tra Tarda Antichita? e Alto Medioevo =$eSettlement patterns in the countryside of Italy between Late Antiquity and the Early Middle Ages /$fa cura di Angelo Castrorao Barba 210 1$aOxford, England :$cArchaeopress Publishing Ltd.,$d[2018] 210 4$d©2018 215 $a1 online resource (190 pages) 225 1 $aLimina/Limites: Archaeologies, Histories, Islands and Borders in the Mediterranean (365-1556) ;$vv.6 311 $a1-78491-823-7 320 $aIncludes bibliographical references. 327 $aCover -- Title Page -- Copyright Information -- Copyright Information -- Contents -- Introduction: Insights on Late Antique and Early Medieval settlement patterns in Italian countryside -- Angelo Castrorao Barba -- Dinamiche di cristianizzazione e di popolamento di uno spazio rurale di confine tra il tardo antico e l'epoca carolingia: il caso della Carnia (Udine) -- Settlement and Christianization patterns of a border rural space between Late Antiquity and the Carolingian age: the case of Carnia (Udine) -- Stefano Roascio -- L'Oltrepò Pavese. Un territorio 'cerniera' tra continuità e trasformazione del paesaggio antico e nascita delle signorie rurali -- Elena Dellù -- L'Oltrepò Pavese. An 'hinge' territory between continuity and change of ancient landscape and the emergence of rural lordship. -- Dinamiche insediative nella Liguria di ponente in età postclassica: la mansio e il complesso paleocristiano di Capo Don a Riva Ligure (Imperia) -- Philippe Pergola,* Alessandro Garrisi,** Alessandro Bona*** and Federico Zoni**** -- Post-classical settlement patterns in West Liguria: the mansio and the early Christian complex of Capo Don at Riva Ligure (Savona) -- Ricerche recenti e nuovi dati dal sito di San Calocero ad Albenga (Savona) tra Tardo Antico e Medioevo -- Philippe Pergola,* Stefano Roascio,** Elena Dellù*** and Gabriele Castiglia**** -- Recent research and new data from the site of San Calocero at Albegna (Savona) between Late Antiquity and the Middle Ages -- 'Inneclesiamento' rurale e reti insediative nella toscana settentrionale (IV-X sec. d.C.) -- Church and settlement rural networks in Northern Tuscany (4th-10th century AD) -- Gabriele Castiglia -- Il sito di Vignale (Livorno) in età tardoantica e i suoi contesti possibili -- Elisabetta Giorgi. 327 $aLa crisi economica degli insediamenti secondari romani nella Toscana meridionale (V-VIII sec. d.C.) ed il caso di Santa Cristina in Caio (Siena) -- Stefano Bertoldi -- The economic crisis of the Roman secondary settlements in southern Tuscany (V-VIII century) and the case of Santa Cristina in Caio (Siena) -- La Sabina in età tardoantica e le nuove ricerche alla villa di Cottanello (Rieti) -- Carla Sfameni -- Il Salento rurale nell'altomedioevo: territorio, insediamenti e cultura materiale -- Paul Arthur, Marco Leo Imperiale and Giuseppe Muci -- Rural Salento during the Early Middle Ages: landscape, settlements and material culture -- La cultura materiale del monachesimo italo-greco: indagini in corso e prospettive di ricerca -- Francesca Zagari -- The material culture of Italo-Greek monasticism: current investigations and research perspectives. 330 $aA series of selected contributions about settlement patterns in the Italian countryside between Late Antiquity and the Early Middle Ages, providing a critical overview of the most recent research on the subject. 410 0$aLimina/Limites: Archaeologies, Histories, Islands and Borders in the Mediterranean (365-1556) 606 $aLand settlement patterns$zItaly$xHistory$vCongresses 606 $aExcavations (Archaeology)$zItaly$vCongresses 606 $aCivilization, Medieval$vCongresses 607 $aItaly$xCivilization$y476-1268$vCongresses 608 $aConference papers and proceedings.$2fast 608 $aHistory.$2fast 615 0$aLand settlement patterns$xHistory 615 0$aExcavations (Archaeology) 615 0$aCivilization, Medieval 676 $a937/.09 702 $aCastrorao Barba$b Angelo$f1983- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910795156603321 996 $aDinamiche insediative nelle campagne dell'Italia tra Tarda Antichità e Alto Medioevo$92789993 997 $aUNINA LEADER 03488nam 22006495 450 001 9910983338303321 005 20250114115227.0 010 $a9789819613014 010 $a9819613019 024 7 $a10.1007/978-981-96-1301-4 035 $a(CKB)37203792500041 035 $a(MiAaPQ)EBC31878994 035 $a(Au-PeEL)EBL31878994 035 $a(DE-He213)978-981-96-1301-4 035 $a(OCoLC)1484883055 035 $a(EXLCZ)9937203792500041 100 $a20250114d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDevelopment of Mirror-Image VHHs with Less Immunogenicity /$fby Keisuke Aoki 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (140 pages) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061 311 08$a9789819613007 311 08$a9819613000 327 $aChapter 1.Introduction -- Chapter 2.Chemical Synthesis of Mirror-Image VHHs and Evaluation of Their Immunogenicity -- Chapter 3.Identification of a Mirror-Image VHH against Vascular Endothelial Growth Factor -- Chapter 4.Synthetic Study of Full-Length Hepatitis B Virus Core Protein and Its Capsid Assembly -- Chapter 5.Chemical Synthesis of Interleukin-6 for Mirror-Image VHH Discovery -- Chapter 6.Conclusions. 330 $aThis book outlines the chemical synthesis of therapeutic targets and a screening process for unexplored mirror-image single-domain antibodies (D-VHH). This book first describes the chemical synthesis of model VHH and the characteristics of both enantiomeric VHHs, including binding activity, biodistribution and immunogenicity. Immunogenicity testing in mice demonstrated that administration of conventional L-VHH induced the generation of anti-drug antibodies while D-VHH-binding antibodies were not observed in D-VHH-immunized mice. Second, it is explained that the T7-phage-based mirror-image screening system was developed to identify D-VHH antibody fragments capable of binding to vascular endothelial growth factors. Additionally, this book details the chemical synthesis of full-length hepatitis B virus core protein and interleukin-6 for the application of exploring D-VHHs and other mirror-image molecules. Demonstrating that it is possible to develop a D-VHH that preferentially binds the native target protein and exhibits reduced immunogenicity, this book is useful for anyone interested in developing alternative biotherapeutics with reduced immunogenicity by combining chemical and biological approaches. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061 606 $aChemistry 606 $aPharmacy 606 $aProteins 606 $aImmunogenetics 606 $aChemical Synthesis 606 $aPharmacy 606 $aProteins 606 $aImmunogenetics 615 0$aChemistry. 615 0$aPharmacy. 615 0$aProteins. 615 0$aImmunogenetics. 615 14$aChemical Synthesis. 615 24$aPharmacy. 615 24$aProteins. 615 24$aImmunogenetics. 676 $a541.39 700 $aAoki$b Keisuke$01785138 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910983338303321 996 $aDevelopment of Mirror-Image VHHs with Less Immunogenicity$94316765 997 $aUNINA