LEADER 00862nam0-2200277 --450 001 9910978685803321 005 20250219132323.0 010 $a978-88-313-6563-5 100 $a20250219d2024----kmuy0itay5050 ba 101 0 $aita 102 $aIT 105 $a 001yy 200 1 $aIntroduzione alla biologia di Aristotele$fGiulia Mingucci 210 $aBologna$cBiblioteca CLUEB$d2024 215 $a342 p.$cill.$d21 cm 225 1 $aSyllabus$v9 300 $aIn appendice: Diagrammi di partizione delle opere biologiche 610 0 $aScienze naturali$aConcezione [di] Aristotele 700 1$aMingucci,$bGiulia$01785412 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910978685803321 952 $a185 ARIS/S 269$b2024/11653$fFLFBC 959 $aFLFBC 996 $aIntroduzione alla biologia di Aristotele$94316944 997 $aUNINA LEADER 05959nam 22008295 450 001 9910299767003321 005 20250605201029.0 010 $a3-319-18539-X 024 7 $a10.1007/978-3-319-18539-2 035 $a(CKB)3710000000467523 035 $a(SSID)ssj0001558523 035 $a(PQKBManifestationID)16183692 035 $a(PQKBTitleCode)TC0001558523 035 $a(PQKBWorkID)14819058 035 $a(PQKB)10396498 035 $a(DE-He213)978-3-319-18539-2 035 $a(MiAaPQ)EBC6311422 035 $a(MiAaPQ)EBC5586421 035 $a(Au-PeEL)EBL5586421 035 $a(OCoLC)919463985 035 $a(PPN)188456899 035 $a(EXLCZ)993710000000467523 100 $a20150827d2015 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aFundamentals of clinical trials /$fby Lawrence M. Friedman, Curt D. Furberg, David L. DeMets, David M. Reboussin, Christopher B. Granger 205 $a5th ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (XXI, 550 p. 49 illus., 7 illus. in color.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a3-319-18538-1 327 $aIntroduction to Clinical Trials -- Ethical Issues -- What is the Question? -- Study Population -- Basic Study Design -- The Randomization Process -- Blinding -- Sample Size -- Baseline Assessment -- Recruitment of Study Participants -- Data Collection and Quality Control -- Assessment and Reporting of Harm -- Assessment of Health Related Quality of Life -- Participant Adherence -- Survival Analysis -- Monitoring Committee Structure & Function -- Statistical Methods Used in Interim Monitoring -- Issues in Data Analysis -- Closeout -- Reporting and Interpreting of Results -- Multicenter Trials -- Regulatory Issues. 330 $aThis is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. Most chapters have been revised considerably from the fourth edition. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing, and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan, and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful. This book has been successfully used for teaching courses in clinical trial methodology. . 606 $aAssaigs clínics$2thub 606 $aStatistics 606 $aPublic health 606 $aEpidemiology 606 $aCancer$xResearch 606 $aOncology 606 $aStatistics for Life Sciences, Medicine, Health Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/S17030 606 $aPublic Health$3https://scigraph.springernature.com/ontologies/product-market-codes/H27002 606 $aEpidemiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H63000 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 608 $aLlibres electrònics$2thub 615 7$aAssaigs clínics 615 0$aStatistics. 615 0$aPublic health. 615 0$aEpidemiology. 615 0$aCancer$xResearch. 615 0$aOncology. 615 14$aStatistics for Life Sciences, Medicine, Health Sciences. 615 24$aPublic Health. 615 24$aEpidemiology. 615 24$aCancer Research. 615 24$aOncology. 676 $a610.724 700 $aFriedman$b Lawrence M$4aut$4http://id.loc.gov/vocabulary/relators/aut$033180 702 $aFurberg$b Curt D$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aDeMets$b David L$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aReboussin$b David M$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aGranger$b Christopher B$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910299767003321 996 $aFundamentals of Clinical Trials$92508612 997 $aUNINA