LEADER 04667nam 2200661 a 450 001 9910973445103321 005 20251017110113.0 010 $a1-280-38012-8 010 $a9786613558039 010 $a0-309-21436-X 035 $a(CKB)2550000000103133 035 $a(EBL)3378972 035 $a(SSID)ssj0000648355 035 $a(PQKBManifestationID)11417834 035 $a(PQKBTitleCode)TC0000648355 035 $a(PQKBWorkID)10597632 035 $a(PQKB)10254351 035 $a(Au-PeEL)EBL3378972 035 $a(CaPaEBR)ebr10557791 035 $a(CaONFJC)MIL355803 035 $a(OCoLC)755123852 035 $a(MiAaPQ)EBC3378972 035 $a(DNLM)1578543 035 $a(BIP)46371716 035 $a(BIP)36114596 035 $a(EXLCZ)992550000000103133 100 $a20120217d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAdverse effects of vaccines $eevidence and causality /$fInstitute of Medicine of the National Academies 205 $a1st ed. 210 $aWashington, D.C. $cNational Academies Press$d2012 215 $a1 online resource (895 p.) 300 $a"Committee to Review Adverse Effects of Vaccines ; Board on Population Health and Public Health Practice." 311 08$a0-309-21435-1 320 $aIncludes bibliographical references and index. 327 $aApproach -- Evaluating biological mechanisms of adverse events -- Measles, mumps, and rubella vaccine -- Varicella virus vaccine -- Influenza vaccine -- Hepatitis A vaccine -- Hepatitis B vaccine -- Human papillomavirus vaccine -- Diphtheria toxoid-, tetanus toxoid-, and acellular pertussis-containing vaccines -- Meningococcal vaccine -- Injection-related adverse events -- Concluding comments. 330 $aIn 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children.Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors. 606 $aVaccination$xComplications 606 $aBacterial diseases$xPrevention 606 $aVirus diseases$xPrevention 615 0$aVaccination$xComplications. 615 0$aBacterial diseases$xPrevention. 615 0$aVirus diseases$xPrevention. 676 $a615.3/72 701 $aStratton$b Kathleen R$01797964 712 02$aInstitute of Medicine (U.S.).$bCommittee to Review Adverse Effects of Vaccines. 712 02$aInstitute of Medicine (U.S.).$bBoard on Population Health and Public Health Practice. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910973445103321 996 $aAdverse effects of vaccines$94445861 997 $aUNINA