LEADER 04397nam 2200673Ia 450 001 9910971771203321 005 20200520144314.0 010 $a1-04-020409-0 010 $a0-429-13066-X 010 $a1-283-00453-4 010 $a9786613004536 010 $a1-4398-1017-6 024 7 $a10.1201/b10279 035 $a(CKB)2560000000058169 035 $a(EBL)665619 035 $a(OCoLC)707067824 035 $a(SSID)ssj0000469781 035 $a(PQKBManifestationID)11312409 035 $a(PQKBTitleCode)TC0000469781 035 $a(PQKBWorkID)10526998 035 $a(PQKB)11393182 035 $a(Au-PeEL)EBL665619 035 $a(CaPaEBR)ebr10447931 035 $a(CaONFJC)MIL300453 035 $a(OCoLC)660509874 035 $a(FINmELB)ELB156323 035 $a(MiAaPQ)EBC665619 035 $a(EXLCZ)992560000000058169 100 $a20100827d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHandbook of adaptive designs in pharmaceutical and clinical development /$fedited by Annpey Pong, Shein-Chung Chow 205 $a1st ed. 210 $aBoca Raton $cCRC Press$d2011 215 $a1 online resource (475 p.) 300 $aDescription based upon print version of record. 311 08$a1-4398-1016-8 320 $aIncludes bibliographical references and index. 327 $aFront cover; Contents; Preface; Editors; Contributors; Chapter 1. Overview of Adaptive Design Methods in Clinical Trials; Chapter 2. Fundamental Theory of Adaptive Designs with Unplanned Design Change in Clinical Trials with Blinded Data; Chapter 3. Bayesian Approach for Adaptive Design; Chapter 4. The Impact of Protocol Amendments in Adaptive Trial Designs; Chapter 5. From Group Sequential to Adaptive Designs; Chapter 6. Determining Sample Size for Classical Designs; Chapter 7. Sample Size Reestimation Design with Applications in Clinical Trials 327 $aChapter 8. Adaptive Interim Analyses in Clinical TrialsChapter 9. Classical Dose-Finding Trial; Chapter 10. Improving Dose-Finding: A Philosophic View; Chapter 11. Adaptive Dose-Ranging Studies; Chapter 12. Seamless Phase I/II Designs; Chapter 13. Phase II/III Seamless Designs; Chapter 14. Sample Size Estimation/Allocation for Two-Stage Seamless Adaptive Trial Designs; Chapter 15. Optimal Response-Adaptive Randomization for Clinical Trials; Chapter 16. Hypothesis-Adaptive Design; Chapter 17. Treatment Adaptive Allocations in Randomized Clinical Trials: An Overview 327 $aChapter 18. Integration of Predictive Biomarker Diagnostics into Clinical Trials for New Drug DevelopmentChapter 19. Clinical Strategy for Study Endpoint Selection; Chapter 20. Adaptive Infrastructure; Chapter 21. Independent Data Monitoring Committees; Chapter 22. Targeted Clinical Trials; Chapter 23. Functional Genome-Wide Association Studies of Longitudinal Traits; Chapter 24. Adaptive Trial Simulation; Chapter 25. Efficiency of Adaptive Designs; Chapter 26. Case Studies in Adaptive Design; Chapter 27. Good Practices for Adaptive Clinical Trials; Back cover 330 $aThis comprehensive guide offers a unified presentation of the principles and methodologies in adaptive design and analysis. It gives a well-balanced summary of current regulatory perspectives and recently developed statistical methods in this area. The handbook provides some insight regarding early phase and later phase adaptive designs. With a focus on the implementation of adaptive methods in clinical trials, it introduces the concepts of role, responsibility, function, and activity of a data safety monitoring board (DSMB) when applying these methods. Other important topics covered in detail include regulatory perspectives and logistics issues in applying adaptive design methods--Provided by publisher. 606 $aClinical trials$vHandbooks, manuals, etc 606 $aDrugs$xResearch$xMethodology$vHandbooks, manuals, etc 615 0$aClinical trials 615 0$aDrugs$xResearch$xMethodology 676 $a615.5072/4 701 $aPong$b Annpey$01829522 701 $aChow$b Shein-Chung$f1955-$0254512 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910971771203321 996 $aHandbook of adaptive designs in pharmaceutical and clinical development$94398944 997 $aUNINA LEADER 03572nam 22006975 450 001 9910725928003321 005 20251113203110.0 010 $a9783031308529 010 $a3031308522 024 7 $a10.1007/978-3-031-30852-9 035 $a(CKB)5590000001065390 035 $a(MiAaPQ)EBC30553113 035 $a(Au-PeEL)EBL30553113 035 $a(DE-He213)978-3-031-30852-9 035 $a(PPN)270615792 035 $a(OCoLC)1380865208 035 $a(ODN)ODN0010068247 035 $a(EXLCZ)995590000001065390 100 $a20230527d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDifferential Equations for Studies in Computational Electrophysiology /$fby Karoline Horgmo Jęger, Aslak Tveito 205 $a1st ed. 2023. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2023. 215 $a1 online resource (134 pages) 225 1 $aReports on Computational Physiology,$x2730-7743 ;$v14 311 08$a9783031308512 311 08$a3031308514 327 $a1. Getting Started -- 2. A System of Ordinary Differential Equations -- 3. The Diffusion Equation -- 4. Implicit Numerical Methods -- 5. Improved Accuracy -- 6. A Simple Cable Equation -- 7. Operator Splitting -- 8. Membrane Models -- 9. The Cable Equation -- 10. Spatial Models of Cardiac Electrophysiology -- 11. The Extracellular-Membrane-Intracellular (EMI) Model -- 12. The Poisson-Nernst-Planck (PNP) Model -- Index. 330 $aThis open access text aims at giving you the simplest possible introduction to differential equations that are used in models of electrophysiology. It covers models at several spatial and temporal scales with associated numerical methods. The text demonstrates that a very limited number of fundamental techniques can be used to define numerical methods for equations ranging from ridiculously simple to extremely complex systems of partial differential equations. Every method is implemented in Matlab and the codes are freely available online. By using these codes, the reader becomes familiar with classical models of electrophysiology, like the cable equation, the monodomain model, and the bidomain model. But modern models that have just started to gain attention in the field of computational electrophysiology are also presented. If you just want to read one book, it should probably not be this one, but if you want a simple introduction to a complex field, it is worth considering the present text. 410 0$aReports on Computational Physiology,$x2730-7743 ;$v14 606 $aMathematics 606 $aComputer science 606 $aBiology 606 $aBioengineering 606 $aMathematics 606 $aComputer Science 606 $aBiological Sciences 606 $aBiological and Physical Engineering 615 0$aMathematics. 615 0$aComputer science. 615 0$aBiology. 615 0$aBioengineering. 615 14$aMathematics. 615 24$aComputer Science. 615 24$aBiological Sciences. 615 24$aBiological and Physical Engineering. 676 $a510 686 $aCOM014000$aMAT000000$aSCI009000$aSCI086000$2bisacsh 700 $aHorgmo Jęger$b Karoline$01363116 701 $aTveito$b Aslak$041984 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910725928003321 996 $aDifferential Equations for Studies in Computational Electrophysiology$93382899 997 $aUNINA