LEADER 05812nam 22007934a 450 001 9910455910303321 005 20200520144314.0 010 $a1-280-50567-2 010 $a9786610505678 010 $a600-00-0589-X 010 $a1-60129-472-7 035 $a(CKB)111087028238676 035 $a(EBL)267542 035 $a(OCoLC)228124762 035 $a(SSID)ssj0000258741 035 $a(PQKBManifestationID)11204431 035 $a(PQKBTitleCode)TC0000258741 035 $a(PQKBWorkID)10256899 035 $a(PQKB)10263034 035 $a(MiAaPQ)EBC267542 035 $a(Au-PeEL)EBL267542 035 $a(CaPaEBR)ebr10116447 035 $a(CaONFJC)MIL50567 035 $a(EXLCZ)99111087028238676 100 $a20020820d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aThiol metabolism and redox regulation of cellular functions$b[electronic resource] /$f[edited by] Alfonso Pompella, Gabor Banhegyi, Maria Wellman-Rousseau 210 $aAmsterdam ;$aWashington, DC $cIOS Press$dc2002 215 $a1 online resource (365 p.) 225 1 $aNATO science series. Series I, Life and behavioural sciences,$x1566-7693 ;$vv. 347 300 $a"Published in cooperation with NATO Scientific Affairs Division." 300 $a"Proceedings of the NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions, 10-13 April 2002, Pisa, Italy"--T.p. verso. 311 $a0-585-45870-7 311 $a1-58603-282-8 320 $aIncludes bibliographical references and index. 327 $aCover; Title page; Foreword; Preface; Contributors; Contents; Oxidative Signaling and Glutathione Synthesis; Cell Survival and Changes in Gene Expression in Cells Unable to Synthesize Glutathione; Role of Glutathione in the Regulation of Liver Metabolism; Glutathione Transport in the Endo/Sarcoplasmic Reticulum; Role of Ascorbate in Oxidative Protein Folding; Cytophotometric Investigations on Oscillating Thiol-Disulfide Equilibria and Oxidized Protein Sulfur; Protection by Pantothenic Acid against Apoptosis and Cell Damage by Oxygen Free Radicals - The Role of Glutathione 327 $aThiols as Major Determinants of the Total Antioxidant CapacityEnzymes of the Thiol-dependent Hydroperoxide Metabolism in Pathogens as Potential Drug Targets; Is there a Role of Glutathione Peroxidases in Signaling and Differentiation?; Multidrug Resistance-associated Proteins: Export Pumps for Conjugates with Glutathione, Glucuronate or Sulfate; Detoxification of Electrophilic Compounds by Glutathione S-Transferase Catalysis: Determinants of Individual Response to Chemical Carcinogens and...; Transcriptional Regulation of Glutathione S-Transferase P1-1 in Human Leukemia 327 $aMechanism of ?-Glutamyltranspeptidase Folding and Activation in the Endoplasmic ReticulumThe Role of ?-Glutamyl Transpeptidase in the Biosynthesis of Glutathione; Role of ?-Glutamyltransferase in the Homeostasis of Glutathione during Oxidative and Nitrosative Stress; The Importance of gamma-Glutamyl Transferase in Lung Glutathione Homeostasis and Antioxidant Defense; The Role of gamma-Glutamyltranspeptidase in the Metabolism and Cytotoxicity of 4-Hydroxynonenal-Glutathione Conjugate: Evidence and Hypothesis; ?-Glutamyltransferase-Dependent Prooxidant Reactions: a Factor in Multiple Processes 327 $aSerum gamma-Glutamyl Transpeptidase: a Prognostic Marker in Cardiovascular DiseasesLipoic Acid: a Multifunctional Antioxidant; Is Glutathione an Important Neuroprotective Effector Molecule against Amyloid Beta Toxicity?; Antioxidants in Cancer Therapy: is there a Rationale to Recommend Antioxidants during Cancer Therapy?; Disulfide Exchange in CD4; Redox Regulation in Protein Folding and Chaperone Function; Reduction of the Endoplasmic Reticulum Accompanies the Oxidative Damage of Diabetes Mellitus; Analytical Developments in the Assay of Intra- and Extracellular GSH Homeostasis 327 $aSignalling Potential and Protein Modifying Ability of Physiological ThiolsRedox Signaling and the Map Kinase Pathways; Redox Regulation of Mitochondrial Permeability Transition: Contrasting Effects of Lipoic Acid and its Positively Charged Analog LA-Plus; Redox State of Glutathione and Thioredoxin in Differentiation and Apoptosis; Redox Regulation of DNA Repair; Author Index 330 $aThis volume contains contributions by some of the leading scientists in the field of thiol oxidation/reduction (redox) biochemistry. It is focused on the biological/pathophysiological implications of newly-discovered functions of cellular thiols, such as glutathione in the first place. 410 0$aNATO science series.$nSeries I,$pLife and behavioural sciences ;$vv. 347. 606 $aAntioxidants$vCongresses 606 $aThiols$xPhysiological effect$vCongresses 606 $aGlutathione$xPhysiological effect$vCongresses 606 $aOxidation-reduction reaction$vCongresses 606 $aCell respiration$vCongresses 608 $aElectronic books. 615 0$aAntioxidants 615 0$aThiols$xPhysiological effect 615 0$aGlutathione$xPhysiological effect 615 0$aOxidation-reduction reaction 615 0$aCell respiration 676 $a572.7 701 $aPompella$b Alfonso$0872209 701 $aBa?nhegyi$b Ga?bor$0872210 701 $aWellman-Rousseau$b Maria$0872211 712 12$aNATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions$f(2002 :$ePisa, Italy) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910455910303321 996 $aThiol metabolism and redox regulation of cellular functions$91947443 997 $aUNINA LEADER 05371nam 2200721Ia 450 001 9910971449803321 005 20200520144314.0 010 $a9786613915054 010 $a9781118301876 010 $a1118301870 010 $a9781283602600 010 $a1283602601 010 $a9781118301869 010 $a1118301862 035 $a(CKB)2670000000246158 035 $a(EBL)1021559 035 $a(OCoLC)810533856 035 $a(SSID)ssj0000711664 035 $a(PQKBManifestationID)12316056 035 $a(PQKBTitleCode)TC0000711664 035 $a(PQKBWorkID)10694201 035 $a(PQKB)11434340 035 $a(MiAaPQ)EBC1021559 035 $a(Au-PeEL)EBL1021559 035 $a(CaPaEBR)ebr10602073 035 $a(CaONFJC)MIL391505 035 $a(Perlego)1011487 035 $a(EXLCZ)992670000000246158 100 $a20120319d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPaediatric intensive care nursing /$fedited by Michaela Dixon, Doreen Crawford 205 $a1st ed. 210 $aChichester, West Sussex $cWiley-Blackwell$d2012 215 $a1 online resource (425 p.) 300 $aDescription based upon print version of record. 311 08$a9781405199360 311 08$a1405199369 320 $aIncludes bibliographical references and index. 327 $aTitle page; Copyright page; Contents; List of Contributors; Acknowledgements; Section 1: Introduction to Paediatric Intensive Care Nursing; Chapter 1: Introduction to Children's Intensive Care; Introduction and background; The organisation of PICU care; Differentiating paediatric intensive care; Commissioning auditing and costing; Standards for staffing and skill mix; Developing roles in PICU; Education in PICU; Higher education and professional body partnerships; New ways of learning in PICU; Conclusion; References 327 $aChapter 2: Assessment and Management of the Critically Ill Child/ResuscitationIntroduction; The priority; Second-level priorities; Fluids and drugs; Calorie requirement and nutrition; Potential impact on development and disability; Indicators of brain injury; Essential nursing care; Skin assessment; Bowel and bladder care in the PICU; Oral hygiene; Eye care; Passive limb physiotherapy; Resuscitation in the PICU; Drugs used in resuscitation; Adrenaline; Amiodarone; Atropine; Sodium bicarbonate; Dextrose; Electrolytes (magnesium and calcium); Parents present during resuscitation 327 $aAdvance directives, personal resuscitation plans, end-of-life instructionsNot for resuscitation; Withdrawing and withholding intervention; Conclusion; References; Chapter 3: Physiological Monitoring of Infants and Children in the Intensive Care Unit; Introduction; General safety and preparation before use; Electrocardiographic (ECG) monitoring; Five-electrode limb leads plus one precordial lead combination; Troubleshooting ECG monitoring (Table ); Twelve-lead ECG recording (Figure ); Atrial wire ECG recordings; Invasive pressure monitoring; Maintaining line patency 327 $aArterial lines and monitoringPhysiology of the arterial pressure-pulse wave (arterial waveform) (Figure ); Central venous pressure (CVP) monitoring; Pulse oximetry; Capnography and ETCO2 monitoring; Near-infrared spectroscopy; Conclusion; References; Section 2: Systems Approach; Chapter 4: Care of an Infant or Child with a Respiratory Illness and/or the Need for Respiratory Support; Introduction; Embryology; Transition to extra-uterine respiratory function; Brief overview of respiratory physiology; The role of surfactant; Gas exchange; Gas transport; Control of respiration 327 $aCentral chemoreceptorsPeripheral chemoreceptors; Lung stretch receptors; Joint and muscle receptors; Irritant receptors; J receptors (juxtacapillary receptors); Ventilation perfusion ratio and mismatch; Pulmonary volumes and capacities; Respiratory assessment; Physical inspection; Cyanosis; Palpation; Crepitus; Pleural friction rub; Percussion; The respiratory rate and rhythm; Auscultation; The chest X-ray; Blood gas analysis; Buffering system; Compensatory mechanisms; Electrolytes and acid base balance; Normal blood gas values; Blood gas interpretation 327 $aSystemic effects of a respiratory acidosis 330 $a The needs of critically ill children are unique and highly specialized. Paediatric Intensive Care Nursing is an essential manual of care and an invaluable resource to all those involved in the care of critically ill children and young people. Covering all the key aspects of pediatric intensive care, it is a fully comprehensive textbook which provides an evidence-based and up-to-date guide for all nurses who work with critically ill children. Paediatric Intensive Care Nursing is divided into four user-friendly sections: The first section looks at the general ba 606 $aPediatric nursing 606 $aIntensive care nursing 615 0$aPediatric nursing. 615 0$aIntensive care nursing. 676 $a618.92/0028 701 $aDixon$b Michaela$01812682 701 $aCrawford$b Doreen$01812683 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910971449803321 996 $aPaediatric intensive care nursing$94365202 997 $aUNINA