LEADER 02894nam 2200709Ia 450 001 9910957548003321 005 20200520144314.0 010 $a9780817912567 010 $a0817912568 035 $a(CKB)2670000000276573 035 $a(EBL)3301881 035 $a(SSID)ssj0000784529 035 $a(PQKBManifestationID)11443008 035 $a(PQKBTitleCode)TC0000784529 035 $a(PQKBWorkID)10763745 035 $a(PQKB)10866907 035 $a(MiAaPQ)EBC3301881 035 $a(Au-PeEL)EBL3301881 035 $a(CaPaEBR)ebr10622934 035 $a(CaONFJC)MIL551677 035 $a(OCoLC)821216878 035 $a(Perlego)971285 035 $a(EXLCZ)992670000000276573 100 $a20101015d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aUp from the projects $ean autobiography /$fWalter E. Williams 205 $a1st ed. 210 $aStanford, Calif. $cHoover Institution Press$d2010 215 $a1 online resource (160 p.) 225 1 $aHoover Institution Press Publication 300 $aDescription based upon print version of record. 311 08$a9780817912543 311 08$a0817912541 320 $aIncludes bibliographical references and index. 327 $a""Front Cover ""; ""Book Title""; ""Copyright ""; ""Acknowledgements ""; ""Contents""; ""Preface""; ""One - Starting Out""; ""Two - Rudderless and Drifting""; ""Three - In the Army Now""; ""Four - Heading West for Opportunity""; ""Five - Heading East for Opportunity""; ""Six - Teaching and Preaching""; ""Seven - Afterthoughts""; ""Index"" 330 $a"From his lower-middle-class beginnings in a mixed but predominantly black neighborhood in West Philadelphia to his department chairmanship at George Mason University, the life of Walter E. Williams is an "only in America" story of achievement. In Up from the Projects, this nationally syndicated columnist and prolific author recalls some of the highlights and turning points of his life"--Jacket p. [4]. 410 0$aHoover Institution Press Publication 606 $aEconomists$vBiography 606 $aAfrican American economists$vBiography 606 $aJournalists$vBiography 606 $aAfrican American journalists$vBiography 606 $aCollege teachers$vBiography 606 $aAfrican American college teachers$vBiography 615 0$aEconomists 615 0$aAfrican American economists 615 0$aJournalists 615 0$aAfrican American journalists 615 0$aCollege teachers 615 0$aAfrican American college teachers 676 $a330.092 700 $aWilliams$b Walter E$g(Walter Edward),$f1936-$01660728 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910957548003321 996 $aUp from the projects$94356561 997 $aUNINA LEADER 05020oam 2200805K 450 001 9910970684603321 005 20241107095055.0 010 $a0-262-31839-3 010 $a0-262-31838-5 024 8 $aebr10803227 035 $a(CKB)2550000001163179 035 $a(EBL)3339708 035 $a(SSID)ssj0001059747 035 $a(PQKBManifestationID)11674147 035 $a(PQKBTitleCode)TC0001059747 035 $a(PQKBWorkID)11084841 035 $a(PQKB)10332200 035 $a(CaBNVSL)mat06670254 035 $a(IDAMS)0b00006481f6dbf6 035 $a(IEEE)6670254 035 $a(OCoLC)863157576$z(OCoLC)863672875$z(OCoLC)864822098$z(OCoLC)971582128$z(OCoLC)971909028$z(OCoLC)1055385038$z(OCoLC)1066662229$z(OCoLC)1081287918 035 $a(OCoLC-P)863157576 035 $a(MaCbMITP)8893 035 $a(Au-PeEL)EBL3339708 035 $a(CaPaEBR)ebr10803227 035 $a(CaONFJC)MIL545317 035 $a(OCoLC)863672875 035 $a(MiAaPQ)EBC3339708 035 $a(PPN)19693608X 035 $a(ODN)ODN0001461932 035 $a(EXLCZ)992550000001163179 100 $a20131118d2014 uy 0 101 0 $aeng 135 $aur|n||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFrom X-rays to DNA $ehow engineering drives biology /$fDavid W. Lee, with Jeffrey Drazen, Phillip A. Sharp, and Robert S. Langer 205 $a1st ed. 210 $d2013 210 1$aCambridge, Massachusetts :$cThe MIT Press,$d[2014] 210 4$dİ2014 215 $a1 online resource (247 p.) 300 $aDescription based upon print version of record. 311 08$a0-262-01977-9 311 08$a1-306-14066-8 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; Acknowledgments; I Introduction ; 1 An Opportunity for Greater Discovery; 2 Concurrent Engineering and Science; 3 Engineering and the Engineer; II From Peas to Genome: Engineering-Enabled Biological Research; 4 Discovery of Chromosomes and the Submicrometer Microscope; 5 DNA: Gels, Paper, and Columns; 6 Structure of DNA and Proteins: X-ray Diffraction; 7 Observing DNA and Protein in Action: Radioisotope Labels; 8 Transcription and Electron Microscopy; 9 Protein and DNA Automated Sequencing; III Concurrent Engineering and Biology 327 $a10 Concurrent versus Nonconcurrent Engineering 11 The Engineers and Scientists of Concurrent Engineering; 12 Institutions and Teams for Concurrent Biology and Engineering; 13 Concurrent Engineering in the Clinic; 14 Unmet Needs: Mapping and Understanding Cell Signaling; 15 Unmet Needs: Cancer Example; 16 Summing Up; Notes; References; Index 330 3 $a"Engineering has been an essential collaborator in biological research and breakthroughs in biology are often enabled by technological advances. Decoding the double helix structure of DNA, for example, only became possible after significant advances in such technologies as X-ray diffraction and gel electrophoresis. Diagnosis and treatment of tuberculosis improved as new technologies -- including the stethoscope, the microscope, and the X-ray -- developed. These engineering breakthroughs take place away from the biology lab, and many years may elapse before the technology becomes available to biologists. In this book, David Lee argues for concurrent engineering -- the convergence of engineering and biological research -- as a means to accelerate the pace of biological discovery and its application to diagnosis and treatment. He presents extensive case studies and introduces a metric to measure the time between technological development and biological discovery. Investigating a series of major biological discoveries that range from pasteurization to electron microscopy, Lee finds that it took an average of forty years for the necessary technology to become available for laboratory use. Lee calls for new approaches to research and funding to encourage a tighter, more collaborative coupling of engineering and biology. Only then, he argues, will we see the rapid advances in the life sciences that are critically needed for life-saving diagnosis and treatment." 606 $aBiomedical engineering 606 $aMedicine$xResearch$xHistory 606 $aMedical instruments and apparatus$xTechnological innovations 606 $aSurgical instruments and apparatus$xTechnological innovations 615 0$aBiomedical engineering. 615 0$aMedicine$xResearch$xHistory. 615 0$aMedical instruments and apparatus$xTechnological innovations. 615 0$aSurgical instruments and apparatus$xTechnological innovations. 676 $a610.28 686 $aSCI008000$aTEC056000$2bisacsh 700 $aLee$b W. David$f1946-$01819442 702 $aDrazen$b Jeffrey M.$f1946- 702 $aSharp$b Phillip A. 702 $aLanger$b Robert S. 801 0$bOCoLC-P 801 1$bOCoLC-P 906 $aBOOK 912 $a9910970684603321 996 $aFrom X-rays to DNA$94379745 997 $aUNINA