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010   $a9781616686116
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100   $a20100322d2010      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aQuantitative immunohistology $eproblems and solutions /$fAnthony S-Y Leong and Trishe Y-M Leong
205   $a1st ed.
210   $aHauppauge, N.Y. $cNova Science Publishers$d2010
215   $a1 online resource (82 p.)
225 1 $aImmunology and immune system disorders
300   $aDescription based upon print version of record.
311 08$a9781616682613 
311 08$a1616682612 
320   $aIncludes bibliographical references and index.
327   $aThe immunohistological assay : a total test approach -- Pre-analytical variables : tissue preservation, transportation, fixation and tissue processing -- Analytical variables : antigen retrieval, antibodies, detection systems and controls -- Post-analytical phase -- Receptor detection for targeted therapies -- Interobserver variability in quantitative immunohistology.
330   $aAs immunohistochemistry enters its fourth decade as a diagnostic tool, this analytical procedure continues to experience poor reproducibility, albeit in specific situations. The problem becomes more important with the mounting pressure to employ the assay in a quantitative manner for the assessment of therapeutic and prognostic markers in a number of neoplasms. Qualitative applications of immunohistochemistry are well established and continue to increase with the range of sensitive antibodies and detection systems available, however, numerous variables that influence the immunoexpression of proteins in formalin-fixed tissue continue to exist in the pre-analytical and analytical phases of the test procedure. This book emphasizes these problems in detail and suggests possible solutions.
410  0$aImmunology and immune system disorders.
606   $aDiagnostic immunohistochemistry
615  0$aDiagnostic immunohistochemistry.
676   $a616.07/56
700   $aLeong$b Anthony S.-Y$g(Anthony Siew-Yin),$f1945-2011.$01493006
701   $aLeong$b Trishe Y-M$01867452
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910970451303321
996   $aQuantitative immunohistology$94475001
997   $aUNINA