LEADER 05585nam 2200805 a 450 001 9910970230403321 005 20230801222502.0 010 $a9786613621641 010 $a9781118307861 010 $a1118307860 010 $a9781280591815 010 $a1280591811 010 $a9781118307854 010 $a1118307852 010 $a9781119943426 010 $a1119943426 010 $a9781119943419 010 $a1119943418 035 $a(CKB)2670000000178690 035 $a(EBL)894816 035 $a(OCoLC)782128101 035 $a(SSID)ssj0000658083 035 $a(PQKBManifestationID)11395701 035 $a(PQKBTitleCode)TC0000658083 035 $a(PQKBWorkID)10680915 035 $a(PQKB)11339406 035 $a(DLC) 2012013150 035 $a(MiAaPQ)EBC894816 035 $a(Au-PeEL)EBL894816 035 $a(CaPaEBR)ebr10558692 035 $a(CaONFJC)MIL362164 035 $a(Perlego)1012055 035 $a(EXLCZ)992670000000178690 100 $a20120329d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPractical methods for biocatalysis and biotransformations 2 /$fedited by John Whittall, Peter W. Sutton 205 $a2 210 $aHoboken $cJohn Wiley & Sons Inc.$d2012 215 $a1 online resource (390 p.) 300 $aDescription based upon print version of record. 311 08$a9781119991397 311 08$a1119991390 320 $aIncludes bibliographical references and index. 327 $aPRACTICAL METHODS FOR BIOCATALYSIS AND BIOTRANSFORMATIONS 2; Contents; List of Contributors; Abbreviations; 1 Biocatalysis in the Fine Chemical and Pharmaceutical Industries; 1.1 Introduction; 1.2 Biotrans Outsourcing - AstraZeneca; 1.3 Biotrans Trends - Lonza; 1.4 Biocatalysis in the Pharma Environment; 1.5 Industrial Use of Hydrolases; 1.6 Industrial Biooxidation and Reduction; 1.7 Industrial Application of Transaminases - Cambrex; 1.8 Biocatalyst Discovery and Improvement; 1.9 From Pathway Engineering to Synthetic Biology 327 $a1.10 Prioritization of Future Biocatalysis and Synthetic Biology Needs1.11 Concluding Remarks; Acknowledgements; References; 2 Reductive Amination; 2.1 ?-Transaminases - Useful Biocatalysts for Chiral Amine Synthesis; 2.2 Preparative Scale Production of a Bulky-Bulky Chiral Amine Using an Engineered Transaminase; 2.3 Synthesis of Optically Pure Amines Employing ?-Transaminases; 2.4 A Fast, Sensitive Assay and Scale-Up of ?-Transaminase Catalysed Reactions; 2.5 Asymmetric Synthesis of L-3-Hydroxyadamantylglycine Using Branched Chain Aminotransferase 327 $a2.6 Asymmetric Reduction of Aryl Imines Using Candida parapsilosis ATCC 73303 Enoate Reductases for Reduction of Electron Deficient Alkenes; 3.1 Asymmetric Bioreduction of Activated Alkenes Using Ene-Reductases from the Old Yellow Enzyme Family; 3.2 Efficient Baker's Yeast Mediated Reduction with Substrate Feeding Product Removal (SFPR) Technology: Synthesis of (S)-2-Alkoxy-3-Aryl-1-Propanols; 3.3 Asymmetric Reduction of (4S)-(+)-Carvone Catalyzed by Enoate Reductases (ERs) Expressed by Non-Conventional Yeast (NCY) Whole Cells 327 $a3.4 Preparation of Enantiomerically Pure Citronellal Enantiomers Using Alkene Reductases3.5 Highly Enantiomeric Hydrogenation of C-C Double Bond of Methylated N-Phenyl and N-Phenylalkylmaleimides by Aspergillus fumigatus; 4 Industrial Carbonyl Reduction; 4.1 Bioreduction Using Immobilized Carbonyl Reductase Technology; 4.2 Preparative Ketoreductase-Catalyzed Kinetic Resolution of a Racemic Aldehyde; 4.3 Enzymatic Reduction of 2,6-dichloro-3-fluoro-acetophenone to Produce (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol 327 $a4.4 Preparative Scale Production of Poorly Soluble Chiral Alcohol Intermediate for Montelukast5 Regio- and Stereoselective Hydroxylation; 5.1 Engineering of an Amycolatopsis orientalis P450 Compactin Hydroxylase into a Pravastatin Synthase by Changing the Stereospecificity of the Enzyme; 5.2 Recombinant Human Cytochrome P450 Enzymes Expressed in Escherichia coli as Whole Cell Biocatalysts: Preparative Synthesis of Oxidized Metabolites of an mGlu5 Receptor Antagonist; 5.3 Alpha-Keto Biooxidation Using Cunninghamella echinulata (DSM 63356) 327 $a5.4 Aromatic Hydroxylation: Preparation of 3,4-Dihydroxyphenylacetic Acid 330 $aBiocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities. Practical Methods for Biocatalysis and Biotransformations 2 is a ""how-to"" guide that focuses on the practical applications of enzymes and strains of microorganisms that are readily obtained or derived from culture collections. The sources of starting materials and reagents, hints, tips and safety advice (where appropria 606 $aEnzymes$xBiotechnology 606 $aBiotransformation (Metabolism) 606 $aOrganic compounds$xSynthesis 615 0$aEnzymes$xBiotechnology. 615 0$aBiotransformation (Metabolism) 615 0$aOrganic compounds$xSynthesis. 676 $a572 701 $aWhittall$b John$01626846 701 $aSutton$b Peter$g(Peter W.)$0866821 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910970230403321 996 $aPractical methods for biocatalysis and biotransformations 2$94359604 997 $aUNINA