LEADER 01621nam 2200385Ia 450 001 996394686403316 005 20200824121756.0 035 $a(CKB)4940000000123650 035 $a(EEBO)2240940378 035 $a(UnM)99896521e 035 $a(UnM)99896521 035 $a(EXLCZ)994940000000123650 100 $a19961126d1650 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 12$aA briefe description of the whole world$b[electronic resource] $eVVherein is particularly described all the monarchies, empires and kingdomes of the same, with their academies. As also their severall titles, and situations thereunto adjoyning. Written by the most Reverend Father in God, George, late Arch-bishop of Canterbuy [sic] 210 $aLondon $cprinted by B. Alsop, and are to be sold by VVilliam Sheares, at the signe of the Harrow in Brittains Burse$d[1650?] 215 $a[4], 329, [3] p 300 $aGeorge, late Arch-bishop of Canterbury = George Abbot. 300 $aDate of publication suggested by Wing (CD-ROM edition). 300 $aThe first leaf is blank. 300 $aReproduction of original in the Folger Shakespeare Library. 330 $aeebo-0055 606 $aUniversities and colleges$vDirectories$vEarly works to 1800 606 $aGeography$vEarly works to 1800 615 0$aUniversities and colleges 615 0$aGeography 700 $aAbbot$b George$f1562-1633.$01002222 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bWaOLN 906 $aBOOK 912 $a996394686403316 996 $aA briefe description of the whole world$92308078 997 $aUNISA LEADER 10514nam 2200769Ia 450 001 9910970118603321 005 20251017110115.0 010 $a9786610215003 010 $a9781280215001 010 $a1280215003 010 $a9780309536332 010 $a0309536332 010 $a9780585028798 010 $a0585028796 035 $a(CKB)110986584750810 035 $a(OCoLC)70772933 035 $a(CaPaEBR)ebrary10060381 035 $a(SSID)ssj0000176905 035 $a(PQKBManifestationID)11182233 035 $a(PQKBTitleCode)TC0000176905 035 $a(PQKBWorkID)10209481 035 $a(PQKB)11584767 035 $a(MiAaPQ)EBC3376814 035 $a(Au-PeEL)EBL3376814 035 $a(CaPaEBR)ebr10060381 035 $a(OCoLC)940510334 035 $a(Perlego)4734847 035 $a(DNLM)684640 035 $a(BIP)13956476 035 $a(EXLCZ)99110986584750810 100 $a20040924d1989 my 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aImmunodeficient rodents $ea guide to their immunobiology, husbandry, and use /$fCommittee on Immunologically Compromised Rodents, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1989 215 $a1 online resource (256 p.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a9780309092876 311 08$a0309092876 311 08$a9780309037969 311 08$a0309037964 320 $aIncludes bibliographical references and index. 327 $aImmunodeficient Rodents -- Copyright -- Preface -- Contents -- 1 Introduction -- IMMUNE SYSTEM FUNCTION -- Host Defense Systems -- The Nature of Adaptive Immunity -- Immunologic Specificity -- Afferent, Central, and Efferent Limbs of the Immune System -- Afferent Limb -- Central Limb -- Efferent Limb -- Immunodeficiency -- EFFECT OF ENVIRONMENTAL FACTORS ON IMMUNE FUNCTION -- Noninfectious Agents -- Infectious Agents -- GENERAL CONSIDERATIONS FOR MAINTAINING IMMUNODEFICIENT RODENTS -- MUTATIONS -- GENE MARKERS AND CHROMOSOME MAPS -- NOMENCLATURE AND SOURCES OF IMMUNODEFICIENT RODENTS -- General Reading -- 2 Hereditary Immunodeficiencies -- MICE WITH SINGLE MUTATIONS -- Bcgr, Bcgs (Resistance and Susceptibility to Mycobacterium bovis) -- Ityr, Itys (Resistance and Susceptibility to Salmonella... -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- bg (Beige) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- db (Diabetes) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- df (Ames Dwarf) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Dh (Dominant Hemimelia) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- dw (Dwarf) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- gl (Grey-Lethal) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- gld (Generalized Lymphoproliferative Disease) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Hc0 (Hemolytic Complement Absent) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- hr (Hairless) -- hrrh (Rhino) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- lh (Lethargic) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- lpr (Lymphoproliferation) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Lpsd (Lipopolysaccharide Response, Defective) -- Genetics. 327 $aPathophysiology -- Husbandry -- Reproduction -- Me (Motheaten) -- Mev (Viable Motheaten) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- mi (Microphthalmia) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- nu (Nude) -- nustr (Streaker) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- ob (Obese) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- oc (Osteosclerotic) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- op (Osteopetrosis) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- scid (Severe Combined Immunodeficiency) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Tol-1 (Tolerance to Gamma-Globulin) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- vit (Vitiligo) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- W (Dominant Spotting) -- Wv (Viable Dominant Spotting) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- wst (Wasted) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- xid (X-Linked Immune Deficiency) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Yaa (Y-Linked Autoimmune Accelerator) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- S-Region-Linked Genes Controlling Murine C4 -- Genetics and Pathophysiology -- Husbandry -- Reproduction -- MICE WITH MULTIPLE MUTATIONS -- gld (Generalized Lymphoproliferative Disease) -- xid (X-Linked Immune Deficiency) -- lpr (Lymphoproliferation) -- nu (Nude) -- lpr (Lymphoproliferation) -- xid (X-Linked Immune Deficiency) -- lpr (Lymphoproliferation) -- Yaa (Y-Linked Autoimmune Accelerator) -- nu (Nude) -- bg (Beige) -- nu (Nude) -- xid (X-Linked Immune Deficiency) -- nu (Nude) -- bg (Beige) -- xid (X-Linked Immune Deficiency) -- nu (Nude) -- Dh (Dominant Hemimelia) -- Yaa (Y-Linked Autoimmune Accelerator) -- bg (Beige). 327 $aYaa (Y-Linked Autoimmune Accelerator) -- xid (X-Linked Immune Deficiency) -- INBRED STRAINS OF MICE -- BSVR, BSVS -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- BXSB/Mp Females -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- DBA/2Ha -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- MRL/Mp -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- NOD (Non-Obese Diabetic) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- NON (Non-Obese Normal) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- NZB (New Zealand Black) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- NZB × NZW F1 Hybrids -- Pathophysiology -- Husbandry -- Reproduction -- NZB × SWR F1 or SWR × NZB F1 Hybrids -- Genetics -- Pathophysiology -- PN (Palmerston North) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- SAM-P (Senescence Accelerated Mouse) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- SJL/J -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- SL/Ni -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- OUTBRED MICE -- SWAN (Swiss Antinuclear) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- RAT MUTANTS -- ia (Incisor Absent) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- op (Osteopetrosis) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- rnu (Rowett Nude) -- rnuN (nznu, New Zealand Nude) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- tl (Toothless) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- C4 Deficiency -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- INBRED STRAINS OF RATS -- BB/Wor and Other Sublines -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- LOU/C -- GUINEA PIG MUTANTS -- C2 Deficiency -- Genetics -- Pathophysiology -- Husbandry. 327 $aReproduction -- C3 Deficiency -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- C4 Deficiency -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- HAMSTER MUTANTS -- nu (Nude) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- C6 Deficiency -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- 3 Induced Immunodeficiencies -- CHEMICAL INDUCERS -- Diethylstilbestrol -- Heavy Metals -- Lead -- Cadmium -- Phenols -- Alkylating Agents -- Glucocorticoids -- INFECTIOUS AGENTS -- NUTRITION -- IONIZING AND ULTRAVIOLET RADIATION -- BIOLOGICAL INDUCERS -- THYMECTOMY -- 4 Maintenance of Rodents Requiring Isolation -- GENERAL CONSIDERATIONS -- SPECIAL FACILITIES AND EQUIPMENT -- Plastic Cages with Filter Covers -- HEPA-Filtered Laminar-Air-Flow Systems -- Germfree Isolators -- Individually Ventilated Cage Racks -- SPECIALIZED HUSBANDRY -- General Considerations -- Environmental Conditions -- Temperature -- Humidity, Ventilation, and Lighting -- Food and Water -- Bedding -- CONTROL OF INFECTION -- Arrival of Stock from Commercial Sources and Transfer of Animals -- Disease Surveillance -- 5 Mating Systems for Mutants -- INBREEDING -- Brother × Sister Inbreeding -- Brother × Sister Inbreeding with Homozygosity -- Brother × Sister Inbreeding with Forced Heterozygosity -- Inbreeding a Balanced Stock -- Transferring a Mutation to an Inbred Background -- Backcross Matings -- Cross-Intercross Matings Using Homozygotes -- Cross-Intercross Matings Using Heterozygotes -- Cross-Intercross Matings Using Ovarian Transplantation -- PROPAGATION WITHOUT INBREEDING -- Transferring a Mutation to a Hybrid Background -- Backcross Matings -- Cross-Intercross Matings -- Cross-Intercross Matings Using Ovarian Transplantation -- 6 Genetic Mechanisms Governing Resistance or Susceptibility to Infectious Diseases -- References -- Appendix. 327 $aGlossary -- Index. 330 $aThis volume is an indispensable reference on the nature of immune defects in rodents and the special techniques necessary to maintain and breed them. The authors describe 64 inbred, hybrid, and mutant strains of rodents, each with some immune defect; explain mechanisms for ensuring genetic purity; and provide a standardized nomenclature for different varieties. Subsequent sections summarize and provide references on the genetics, pathophysiology, husbandry, and reproduction of each of the various strains as well as sound advice on planning for the selection, transportation, housing, and maintenance of these animals. 606 $aImmunological deficiency syndromes$xAnimal models 606 $aRodents$xImmunology 606 $aRodents as laboratory animals 615 0$aImmunological deficiency syndromes$xAnimal models. 615 0$aRodents$xImmunology. 615 0$aRodents as laboratory animals. 676 $a599.32/30429 712 02$aInstitute of Laboratory Animal Resources (U.S.).$bCommittee on Immunologically Compromised Rodents. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910970118603321 996 $aImmunodeficient rodents$94357990 997 $aUNINA