LEADER 03882nam 2200697Ia 450 001 9910970099403321 005 20251116175739.0 010 $a0-429-07779-3 010 $a1-4822-8345-X 010 $a1-280-05339-9 010 $a9786610053391 010 $a0-203-30361-X 024 7 $a10.1201/9781482283457 035 $a(CKB)1000000000252010 035 $a(EBL)181537 035 $a(OCoLC)56909274 035 $a(SSID)ssj0000282041 035 $a(PQKBManifestationID)11232242 035 $a(PQKBTitleCode)TC0000282041 035 $a(PQKBWorkID)10316635 035 $a(PQKB)10676856 035 $a(MiAaPQ)EBC181537 035 $a(Au-PeEL)EBL181537 035 $a(CaPaEBR)ebr10097383 035 $a(CaONFJC)MIL5339 035 $a(OCoLC)560074402 035 $a(EXLCZ)991000000000252010 100 $a19990513d1998 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular biology of Alzheimer's disease $egenes and mechanisms involved in amyloid generation /$fedited by Christian Haass 205 $a1st ed. 210 $aAmsterdam, The Netherlands $cHarwood Academic Publishers$dc1998 215 $a1 online resource (350 p.) 300 $aDescription based upon print version of record. 311 08$a90-5702-381-4 320 $aIncludes bibliographical references and index. 327 $aBook Cover; Title; Contents; Contributors; Introduction; Amyloid Morphology and Pathology of Alzheimer's Disease; The Tau Proteins in Alzheimer's Disease; Mutations in Three Genes are Associated with Early Onset Alzheimer's Disease; The Biological Activities and Function of the Amyloid Precursor Protein of Alzheimer's Disease; Proteolytic Processing of the -Amyloid Precursor Protein; Biosynthesis of APP and A: Multiple Pathways for the Generation of Intracellular A; The Cell Biology of Amyloid Precursor Protein 327 $aThe Role of Amyloid -Peptide Terminating at Amino Acid 42 in Early Onset Alzheimer's DiseaseThe Biophysics of Amyloid -Protein Fibrillogenesis; The Molecular Biology of Presenilin 1; Molecular Biology of Presenilin 2; Presenilin Proteins and their Role in Development and Notch Signaling; The Processing of the Amyloid-Precursor-Protein (APP) in Presenilin-1 Deficient Neurons; Presenilins and their Role in Apoptosis; The Phosphorylation of Presenilin Proteins; APOE and its Role in Late Onset Alzheimer's Disease 327 $aTransgenic Animal Models in the Development of Therapeutic Strategies for Alzheimer's DiseasePresenilins in Transgenic Mice; Index 330 $aHighlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, r 606 $aAlzheimer's disease$xGenetic aspects 606 $aAlzheimer's disease$xMolecular aspects 606 $aAmyloid beta-protein precursor 606 $aMolecular neurobiology 615 0$aAlzheimer's disease$xGenetic aspects. 615 0$aAlzheimer's disease$xMolecular aspects. 615 0$aAmyloid beta-protein precursor. 615 0$aMolecular neurobiology. 676 $a616.831 701 $aHaass$b Christian$01876066 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910970099403321 996 $aMolecular biology of Alzheimer's disease$94487431 997 $aUNINA