LEADER 07469nam 2200709 a 450 001 9910970044203321 005 20200520144314.0 010 $a9786610196050 010 $a9780309176927 010 $a0309176921 010 $a9781280196058 010 $a128019605X 010 $a9780309585774 010 $a0309585775 010 $a9780585019949 010 $a0585019940 035 $a(CKB)110986584751328 035 $a(OCoLC)42854156 035 $a(CaPaEBR)ebrary10055204 035 $a(SSID)ssj0000239095 035 $a(PQKBManifestationID)11218336 035 $a(PQKBTitleCode)TC0000239095 035 $a(PQKBWorkID)10253371 035 $a(PQKB)10562517 035 $a(MiAaPQ)EBC3376208 035 $a(Au-PeEL)EBL3376208 035 $a(CaPaEBR)ebr10055204 035 $a(CaONFJC)MIL19605 035 $a(OCoLC)923261960 035 $a(Perlego)4736464 035 $a(EXLCZ)99110986584751328 100 $a19960208d1996 ua 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRodents /$fCommittee on Rodents, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1996 215 $a1 online resource (179 pages) $cillustrations 225 1 $aLaboratory animal management 300 $aBibliographic Level Mode of Issuance: Monograph 311 0 $a9780309049368 311 0 $a0309049369 320 $aIncludes bibliographical references and index. 327 $aRodents -- Copyright -- Preface -- Contents -- 1 Laboratory Animals and Public Perspective -- REGULATORY ISSUES -- ETHICAL CONSIDERATIONS -- REFERENCES -- 2 Responsibilities of Animal Care and Use Committees -- PROGRAM OVERSIGHT -- PROTOCOL REVIEW -- PERSONNEL QUALIFICATIONS AND TRAINING -- OCCUPATIONAL HEALTH AND SAFETY -- USE OF HAZARDOUS AGENTS -- REFERENCES -- 3 Criteria for Selecting Experimental Animals -- SPECIES AND STOCKS -- Choosing a Species for Study -- Rodent Stocks -- Genetically Defined Stocks -- Nongenetically Defined Stocks -- STANDARDIZED NOMENCLATURE FOR RODENTS -- Inbred Strains -- Substrains -- Laboratory Codes -- F1 Hybrids -- Coisogenic, Congenic, and Segregating Inbred Strains -- Recombinant Inbred (RI) Strains -- Genes -- Loci That Are Members of a Series -- Alleles -- Transgenes -- Outbred Stocks -- QUALITY -- Microbiologic Quality -- Genetic Quality -- SELECTED ASPECTS OF EXPERIMENTAL DESIGN -- REFERENCES -- 4 Genetic Management of Breeding Colonies -- GENETICALLY DEFINED STOCKS -- Pedigrees -- Traceability -- Selection of Parental Pairs -- Genetic Uniformity -- Foundation or Nucleus Colonies, Expansion Colonies, and Production Colonies -- NONGENETICALLY DEFINED STOCKS -- CRYOPRESERVATION -- RECORD-KEEPING -- REFERENCES -- 5 Husbandry -- HOUSING -- Caging -- Housing Systems -- Space Recommendations -- ENVIRONMENT -- Microenvironment -- Temperature -- Humidity -- Ventilation -- Ventilation Rate -- Air Quality -- Relative Air Pressures -- Cage Ventilation -- Illumination -- Spectral Distribution -- Photoperiod -- Intensity -- Noise -- FOOD -- Types of Diets -- Criteria for Selecting Optimal Rations -- Quality Assurance -- Caloric Restriction -- WATER -- BEDDING -- SANITATION -- Cleaning -- Waste Containment and Disposal -- Pest Control -- IDENTIFICATION AND RECORDS -- RODENTS OTHER THAN RATS AND MICE -- Guinea Pigs. 327 $aHamsters -- Gerbils -- Chinchillas -- REFERENCES -- 6 Veterinary Care -- PREVENTIVE MEDICINE -- Procurement -- Sources -- Transportation -- Quarantine and Stabilization -- Separation by Species, Source, and Health Status -- SURVEILLANCE, DIAGNOSIS, TREATMENT, AND CONTROL OF DISEASE -- Daily Observations of Animals -- Control of Infectious Diseases -- Sample Size for Monitoring -- Treatment and Control -- Necropsies -- EMERGENCY, WEEKEND, AND HOLIDAY CARE -- MINIMIZATION OF PAIN AND DISTRESS -- Recognition of Pain and Distress -- Alleviation of Pain -- Alleviation of Stress and Distress -- SURVIVAL SURGERY AND POSTSURGICAL CARE -- Anesthetics and Tranquilizers -- Preparation for Survival Surgery -- Sterilization of Instruments -- Monitoring During Surgery -- Postoperative Care -- EUTHANASIA -- REFERENCES -- 7 Facilities -- LOCATION AND DESIGN -- Centralization Versus Decentralization -- Functional Areas -- Space Requirements -- Relative Relationships of Space -- Corridors, Vestibules, and Anterooms -- Interstitial Space -- CONSTRUCTION AND ARCHITECTURAL FINISHES -- MONITORING -- SPECIAL REQUIREMENTS -- SECURITY -- REFERENCES -- 8 Rodents that Require Special Consideration -- IMMUNODEFICIENT RODENTS -- Husbandry -- Plastic Cages with Filter Tops -- Individually Ventilated Plastic Cages with Filter Tops -- Isolators -- HEPA-Filtered Airflow Systems -- Environmental Considerations -- Food and Bedding -- Water -- Health Monitoring -- WILD RODENTS -- Hazards -- Care and Breeding -- Peromyscus -- Woodchucks -- AGING COHORTS -- General Considerations -- Laboratory Mice -- Rats (Rattus norvegicus) -- Husbandry -- Record-Keeping -- Transportation and Stabilization -- Veterinary Care and Surveillance -- Other Rodent Species Used for Gerontological Research -- Other Species of Mus -- Peromyscus spp. -- Guinea Pigs -- Hamsters -- Gerbils. 327 $aRODENT MODELS OF INSULIN-DEPENDENT DIABETES MELLITUS -- Diabetes-Prone and Diabetes-Resistant Rats -- Breeding Techniques and Genetic Records -- Husbandry and Care -- Use of Spleen Cells to Reduce Frequency of Diabetes and Improve Breeding Efficiency -- Shipping Pathogen-Free Rats -- NOD Mice -- TRANSGENIC MICE -- Colony Management -- Embryo Donors -- Embryo Recipients -- Offspring -- Breeding Transgenic Mice -- Identification, Records, and Genetic Monitoring -- Embryo Cryopreservation -- Data Management -- Shipment and Receipt of Transgenic Rodents -- Human Health Hazards -- Administrative Issues -- REFERENCES -- Appendix Sources of Information on Importing Rodents -- Index. 330 $aDuring the 15 years since the Institute of Laboratory Animal Resources issued its last report on the general management of rodents, advances in biomedical technology and increased public awareness of laboratory animal issues have created a new research environment. This book brings researchers up to date on both of these aspects of laboratory investigation and provides a comprehensive resource manual for management of laboratory rodents. It reviews relevant laws and ethical considerations, and it examines the role and responsibilities of mandatory institutional animal care and use committees. The expert panel addresses animal selection, sources of laboratory rodents, nomenclature and record keeping, management of genetically and nongenetically defined colonies, and management of animals with special needs. Investigators will find detailed guidance on housing, environment, sanitation, diet and caloric restriction, and facilities design. 410 0$aLaboratory animal management. 606 $aRodents as laboratory animals 615 0$aRodents as laboratory animals. 676 $a619/.93 712 02$aInstitute of Laboratory Animal Resources (U.S.).$bCommittee on Rodents. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910970044203321 996 $aRodents$92702630 997 $aUNINA LEADER 01321nam0 22003131i 450 001 UON00300113 005 20231205104000.265 010 $a03-89202-94-0 100 $a20070802d1982 |0itac50 ba 101 $aeng 102 $aGB 105 $a|||| 1|||| 200 1 $aˆThe ‰artist and society in Shakespeare's England$ethe collected papers of Muriel Bradbrook. 1. / M.C. Bradbrook 210 $aBrighton$cThe Harvester Press ; New Jersey$cBarnes & Noble Books$d1982 215 $ax, 176 p.$d23 cm. 606 $aLETTERATURA INGLESE$xSec. 16.-17.$xStudi$3UONC065586$2FI 606 $aShakespeare William$3UONC038333$2FI 620 $aGB$dBrighton$3UONL001101 620 $aUS$dNew Jersey$3UONL001700 676 $a820.3$cLetteratura inglese. Periodo elisabettiano, 1558-1625$v21 700 1$aBRADBROOK$bM.C.$3UONV172530$0603734 712 $aBarnes & Noble$3UONV257852$4650 712 $aThe Harvester Press$3UONV273306$4650 801 $aIT$bSOL$c20250704$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00300113 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI Angl II C 299 $eSI LO 23684 5 299 996 $aArtist and society in Shakespeare's England$91380525 997 $aUNIOR