LEADER 13222nam 2200817Ia 450 001 9910970042803321 005 20251017110103.0 010 $a9786610196654 010 $a9781280196652 010 $a1280196653 010 $a9780309576321 010 $a0309576326 010 $a9780585158693 010 $a058515869X 035 $a(CKB)110986584751302 035 $a(SSID)ssj0000099469 035 $a(PQKBManifestationID)11113195 035 $a(PQKBTitleCode)TC0000099469 035 $a(PQKBWorkID)10017371 035 $a(PQKB)11329742 035 $a(Au-PeEL)EBL3376733 035 $a(CaPaEBR)ebr10057010 035 $a(OCoLC)817957626 035 $a(MiAaPQ)EBC3376733 035 $a(Perlego)4734424 035 $a(DNLM)739666 035 $a(BIP)12806373 035 $a(EXLCZ)99110986584751302 100 $a19930813d1994 ua 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdverse events associated with childhood vaccines $eevidence bearing on causality /$fKathleen R. Stratton, Cynthia J. Howe, and Richard B. Johnston, Jr., editors 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1994 215 $a1 online resource (480 pages) 300 $a"Vaccine Safety Committee, Division of Health Promotion and Disease Prevention, Institute of Medicine." 300 $a"The project was supported by funds coordinated through the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (contract no. NO-AI-15130)"--T.p. verso. 311 0 $a9780309074964 311 0 $a0309074967 311 0 $a9780309048958 311 0 $a0309048958 320 $aIncludes bibliographical references (p. 348-450) and index. 327 $aAdverse Events Associated with CHILDHOOD VACCINES -- Copyright -- Preface -- Acknowledgments -- Contents -- 1 Executive Summary -- BACKGROUND AND HISTORY -- THE CHARGE TO THE COMMITTEE -- THE STUDY PROCESS -- CAUSALITY AND WEIGHT OF EVIDENCE -- NEED FOR RESEARCH AND SURVEILLANCE -- REFERENCES -- 2 Causality and Evidence -- CAUSALITY -- Definitions -- Types of Causal Questions -- Can It? -- Did It? -- Will It? -- SOURCES OF EVIDENCE FOR CAUSALITY -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Combining the Evidence -- SUMMARIZING THE EVIDENCE FOR CAUSALITY -- REFERENCES -- 3 Neurologic Disorders -- DEMYELINATING DISEASE -- Experimental Models -- Acute Disseminated Encephalomyelitis -- Multiple Sclerosis -- Focal Lesions -- Guillain-Barré Syndrome -- Historical Background -- Clinical and Laboratory Features -- Diagnostic Criteria -- Antecedent Events -- Pathology and Pathogenesis -- Descriptive Epidemiology -- Summary of Demyelinating Diseases -- NON-DEMYELINATING DISEASE -- Encephalopathy -- Subacute Sclerosing Panencephalitis -- Clinical and Laboratory Features -- Pathology and Pathogenesis -- Descriptive Epidemiology -- Residual Seizure Disorder -- Sensorineural Deafness -- Neuropathy -- Mononeuropathy -- Brachial Neuritis -- REFERENCES -- 4 Immunologic Reactions -- ANAPHYLAXIS -- INTERACTION OF ANTIBODY WITH NORMAL TISSUE ANTIGENS -- ARTHUS REACTION -- DELAYED-TYPE HYPERSENSITIVITY -- EFFECT OF VACCINES ON THE IMMUNE SYSTEM -- REFERENCES -- 5 Diphtheria and Tetanus Toxoids -- BACKGROUND AND HISTORY -- Tetanus -- Diphtheria -- BIOLOGIC EVENTS FOLLOWING IMMUNIZATION -- Tetanus -- Diphtheria -- ENCEPHALOPATHY -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility. 327 $aCase Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- RESIDUAL SEIZURE DISORDER -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series. and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- GUILLAIN-BARRÉ SYNDROME -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- NEUROPATHY -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- ARTHRITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- ERYTHEMA MULTIFORME -- Clinical Description -- History of Suspected Association. 327 $aEvidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- ANAPHYLAXIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- DEATH -- Causality Argument -- Conclusion -- REFERENCES -- 6 Measles and Mumps Vaccines -- BACKGROUND AND HISTORY -- Measles -- Mumps -- BIOLOGIC EVENTS FOLLOWING IMMUNIZATION -- Measles -- Mumps -- ENCEPHALOPATHY AND ENCEPHALITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- ASEPTIC MENINGITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- SUBACUTE SCLEROSING PANENCEPHALITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- RESIDUAL SEIZURE DISORDER -- Clinical Description -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies. 327 $aControlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- SENSORINEURAL DEAFNESS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- OPTIC NEURITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- TRANSVERSE MYELITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Studies, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- GUILLAIN-BARRÉ SYNDROME -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- INSULIN-DEPENDENT DIABETES MELLITUS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- STERILITY DUE TO ORCHITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies. 327 $aControlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- THROMBOCYTOPENIA -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- ANAPHYLAXIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- DEATH -- Causality Argument -- Conclusion -- REFERENCES -- 7 Polio Vaccines -- BACKGROUND AND HISTORY -- BIOLOGIC EVENTS FOLLOWING IMMUNIZATION -- POLIOMYELITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- TRANSVERSE MYELITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- GUILLAIN-BARRÉ SYNDROME -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors. 327 $aANAPHYLAXIS AND THROMBOCYTOPENIA. 330 $aChildhood immunization is one of the major public health measures of the 20th century and is now receiving special attention from the Clinton administration. At the same time, some parents and health professionals are questioning the safety of vaccines because of the occurrence of rare adverse events after immunization. This volume provides the most thorough literature review available about links between common childhood vaccines--tetanus, diphtheria, measles, mumps, polio, Haemophilus influenzae b, and hepatitis B--and specific types of disorders or death. The authors discuss approaches to evidence and causality and examine the consequences--neurologic and immunologic disorders and death--linked with immunization. Discussion also includes background information on the development of the vaccines and details about the case reports, clinical trials, and other evidence associating each vaccine with specific disorders. This comprehensive volume will be an important resource to anyone concerned about the immunization controversy: public health officials, pediatricians, attorneys, researchers, and parents. 606 $aVaccination of children$xComplications 606 $aVaccines$xHealth aspects 606 $aVaccines$xToxicology 615 0$aVaccination of children$xComplications. 615 0$aVaccines$xHealth aspects. 615 0$aVaccines$xToxicology. 676 $a615/.372/083 701 $aStratton$b Kathleen R$01797964 701 $aHowe$b Cynthia J$01085443 701 $aJohnston$b Richard B.$f1935-$01812062 712 02$aInstitute of Medicine (U.S.).$bVaccine Safety Committee. 712 02$aNational Institute of Allergy and Infectious Diseases (U.S.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910970042803321 996 $aAdverse events associated with childhood vaccines$94366872 997 $aUNINA