LEADER 05412nam 2200565Ia 450 001 9910969827703321 005 20251116181552.0 010 $a1-60876-720-5 035 $a(CKB)2550000001041403 035 $a(EBL)3018589 035 $a(SSID)ssj0000836221 035 $a(PQKBManifestationID)11461968 035 $a(PQKBTitleCode)TC0000836221 035 $a(PQKBWorkID)11007781 035 $a(PQKB)10628907 035 $a(MiAaPQ)EBC3018589 035 $a(Au-PeEL)EBL3018589 035 $a(CaPaEBR)ebr10660450 035 $a(OCoLC)923659016 035 $a(BIP)26717838 035 $a(EXLCZ)992550000001041403 100 $a20090213d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTelomeres $efunction, shortening and lengthening /$fLeonardo Mancini, editor 205 $a1st ed. 210 $aNew York $cNova Biomedical Books$dc2009 215 $a1 online resource (498 p.) 300 $aDescription based upon print version of record. 311 08$a1-60692-350-1 320 $aIncludes bibliographical references and index. 327 $aTelomere dynamics and biology in human progeroid syndromes / Terence Davis, Hannah S.E. Tivey, and David Kipling -- The role of telomere-telomerase system in age-related fitness decline : a tameable process / Giacinto Libertini -- Cytogenetic evaluation of telomere dysfunction : chromosomal aberrations involving telomeres and interstitial telomeric sequences / Alejandro D. Bolza?n -- Telomeres-telomerase biology and their role in renal and other chronic diseases / Kordinas Vasileios ... [et al.] -- Telomerase and telomere dynamics in cancer : clinical application for cancer diagnosis / Eiso Hiyama, Keiko Hiyama -- Telomeres and chromosome segregation / Antonella Sgura and Daniela Cimini -- Telomere-based genome-protective responses : a mammalian improvement on the bacterial SOS response? / Barbara A. Gilchrest, Mark S. Eller -- Telomere lengthening from oocyte to embryonic stem cell / Eva Pericuesta ... [et al.] -- Transcriptional activity at the telomeres of chironomus (diptera) : its possible role in the lengthening of the telomeres / J.L. Diez ... [et al.] -- 327 $aTelomerase activity : application to diagnosis of human carcinoma / Liliana N. Guerra -- Telomere shortening in diabetes mellitus / Nicholas Tentolouris, Athanasia Papazafiropoulou -- Do alterations in the three-dimensional organization of telomeres indicate malignant transformation? / Sandrine Lacoste, Hans Knecht, and Sabine Mai -- Telomeres : function, shortening and lengthening / Barry Flanary -- Telomerase regulation in stem cells : how to flip the switch? / Rich Allsopp -- Telomere maintenance mechanisms in bone and soft tissue tumors / Toshihiro Matsuo ... [et al.] -- Genetic polymorphisms of human telomerase reverse transcriptase (hTERT) : mini review / Yumiko Matsubara, Mitsuru Murata, and Yasuo Ikeda -- Genetic inhibition of telomere lengthening in cancer prevention and treatment / F. Mathias Bollmann -- Telomeres : function, shortening, and lengthening / Barry Flanary -- Clinical implications of telomerase activity in human brain tumors / Hyoung-Joon Chun ... [et al.]. 330 $aTelomeres are a region of repetitive DNA at the end of chromosomes, which protects the end of the chromosome from destruction. They protect chromosome ends from degradation and thus prevent chromosome end fusion. This book describes the relevance of telomeres in the human aging process and the telomere defects that play a role in the premature aging process. Dysfunctional telomeres that can promote chromosome instability, leading to DNA amplifications and terminal deletions-, cell cycle arrest and cell death, are also described. The biology and function of both telomeres and telomerase are described in this book. The possible connection between telomeres, ageing and senescence, as well as the many disorders and chronic diseases where telomere biology seems to be important are addressed, as well as future therapeutic perspectives. The importance of this enzyme in cancer is reviewed in this book. The data of various kind of cancers are discussed, in addition to the clinical application of telomere and telomerase in human cancer. The role of telomere dysfunction in apoptosis and senescence, as well as its role in newly proposed models that link telomere loss to chromosome missegregation in mitosis, are explained. Characteristic differences of telomere lengthening during oocyte and spermatozoa growth(during embryo development) is also reviewed as well as the transcriptional activity at the telomeres of Chironomus (Diptera) and its possible role in the lengthening of the telomeres. Telomere shortening in Diabetes Mellitus is also described, as well as its association with hypertension, diabetes mellitus, insulin resistance, obesity and cardiovascular mortality. The notion that alterations in the three-dimensional organization of telomeres may cause malignant transformation is also addressed. 606 $aTelomere 606 $aTelomerase 615 0$aTelomere. 615 0$aTelomerase. 676 $a572.8/7 701 $aMancini$b Leonardo$01870178 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910969827703321 996 $aTelomeres$94478544 997 $aUNINA