LEADER 04639nam 22005295 450 001 9910969792603321 005 20250801070442.0 024 7 $a10.1007/978-1-4612-2294-1 035 $a(PPN)238035239 035 $a(CKB)1000000000521044 035 $a(SSID)ssj0000192610 035 $a(PQKBManifestationID)11166412 035 $a(PQKBTitleCode)TC0000192610 035 $a(PQKBWorkID)10197596 035 $a(PQKB)10134034 035 $a(MiAaPQ)EBC3076965 035 $a(DE-He213)978-1-4612-2294-1 035 $a(EXLCZ)991000000000521044 100 $a20121227d1997 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aLinear Mixed Models in Practice $eA SAS-Oriented Approach /$fedited by Geert Verbeke, Geert Molenberghs 205 $a1st ed. 1997. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d1997. 215 $a1 online resource (319 pages) 225 1 $aLecture Notes in Statistics,$x2197-7186 ;$v126 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a0-387-98222-1 327 $a1 Introduction -- 2 An Example-Based Tour in Linear Mixed Models -- 2.1 Fixed Effects and Random Effects in Mixed Models -- 2.2 General Linear Mixed Models -- 2.3 Variance Components Estimation and Best Linear Unbiased Prediction -- 2.4 Fixed Effects: Estimation and Hypotheses Testing -- 2.5 Case Studies -- 3 Linear Mixed Models for Longitudinal Data -- 3.1 Introduction -- 3.2 The Study of Natural History of Prostate Disease -- 3.3 A Two-Stage Analysis -- 3.4 The General Linear Mixed-Effects Model -- 3.5 Example -- 3.6 The RANDOM and REPEATED Statements -- 3.7 Testing and Estimating Contrasts of Fixed Effects -- 3.8 PROC MIXED versus PROC GLM -- 3.9 Tests for the Need of Random Effects -- 3.10 Comparing Non-Nested Covariance Structures -- 3.11 Estimating the Random Effects -- 3.12 General Guidelines for Model Construction -- 3.13 Model Checks and Diagnostic Tools ? -- 4 Case Studies -- 4.1 Example 1: Variceal Pressures -- 4.2 Example 2: Growth Curves -- 4.3 Example 3: Blood Pressures -- 4.4 Example 4: Growth Data -- 5 Linear Mixed Models and Missing Data -- 5.1 Introduction -- 5.2 Missing Data -- 5.3 Approaches to Incomplete Data -- 5.4 Complete Case Analysis -- 5.5 Simple Forms of Imputation -- 5.6 Available Case Methods -- 5.7 Likelihood-Based Ignorable Analysis and PROC MIXED -- 5.8 How Ignorable Is Missing At Random ? ? -- 5.9 The Expectation-Maximization Algorithm ? -- 5.10 Multiple Imputation ? -- 5.11 Exploring the Missing Data Process -- A Inference for Fixed Effects -- A.1 Estimation -- A.2 Hypothesis Testing -- A.3 Determination of Degrees of Freedom -- A.4 Satterthwaite?s Procedure -- B Variance Components and Standard Errors -- C Details on Table 2.10: Expected Mean Squares -- D Example 2.8: Cell Proliferation -- References. 330 $aThe dissemination of the MIXED procedure in SAS has provided a whole class of statistical models for routine use. We believe that both the ideas be­ hind the techniques and their implementation in SAS are not at all straight­ forward and users from various applied backgrounds, including the phar­ maceutical industry, have experienced difficulties in using the procedure effectively. Courses and consultancy on PROC MIXED have been in great demand in recent years, illustrating the clear need for resource material to aid the user. This book is intended as a contribution to bridging this gap. We hope the book will be of value to a wide audience, including applied statisticians and many biomedical researchers, particularly in the pharma­ ceutical industry, medical and public health research organizations, con­ tract research organizations, and academic departments. This implies that our book is explanatory rather than research oriented and that it empha­ sizes practice rather than mathematical rigor. In this respect, clear guidance and advice on practical issues are the main focus of the text. Nevertheless, this does not imply that more advanced topics have been avoided. Sections containing material of a deeper level have been sign posted by means of an asterisk. 410 0$aLecture Notes in Statistics,$x2197-7186 ;$v126 606 $aBiometry 606 $aBiostatistics 615 0$aBiometry. 615 14$aBiostatistics. 676 $a519.5/3 686 $a62J12$2msc 700 $aVerbeke$b Geert$0259366 702 $aMolenberghs$b Geert 801 0$bPQKB 906 $aBOOK 912 $a9910969792603321 996 $aLinear Mixed Models in Practice$94436048 997 $aUNINA