LEADER 05612nam 2200625Ia 450 001 9910968637603321 005 20251116215520.0 010 $a1-280-74247-X 010 $a9786610742479 010 $a0-309-66360-1 024 3 $z9780309102834 (pbk.) 024 3 $z9780309663601 (pdf) 035 $a(CKB)1000000000471149 035 $a(EBL)3378155 035 $a(SSID)ssj0000106703 035 $a(PQKBManifestationID)11140445 035 $a(PQKBTitleCode)TC0000106703 035 $a(PQKBWorkID)10111232 035 $a(PQKB)10485143 035 $a(MiAaPQ)EBC3378155 035 $a(Au-PeEL)EBL3378155 035 $a(CaPaEBR)ebr10156524 035 $a(CaONFJC)MIL74247 035 $a(OCoLC)923277130 035 $a(BIP)13620789 035 $a(EXLCZ)991000000000471149 100 $a20070209d2006 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAssessing the human health risks of trichloroethylene $ekey scientific issues /$fCommittee on Human Health Risks of Trichloroethylene, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies 205 $a1st ed. 210 $aWashington, D.C. $cNational Academies Press$dc2006 215 $a1 online resource (448 p.) 300 $aDescription based upon print version of record. 311 08$a0-309-10283-9 320 $aIncludes bibliographical references (p. 329-379). 327 $a""Front Matter""; ""Preface""; ""Contents""; ""Summary""; ""1 Introduction""; ""2 Methodological Considerations in Evaluating the Epidemiologic Literature on Cancer and Exposure to Trichloroethylene""; ""3 Kidney Toxicity and Cancer""; ""4 Liver Toxicity and Cancer""; ""5 Reproductive and Developmental Toxicity""; ""6 Neurotoxicity""; ""7 Respiratory Tract Toxicity and Cancer""; ""8 Immunotoxicity""; ""9 Special Populations and Susceptibility""; ""10 Mixtures""; ""11 Pharmacokinetic Modeling""; ""12 Issues in the Assessment of Dose Response""; ""References""; ""Appendixes"" 327 $a""Appendix A Biographic Information on the Committee on Human Health Risks of Trichloroethylene""""Appendix B Participants at Public Sessions""; ""Appendix C Trichloroethylene Metabolism""; ""Appendix D Exposure Analysis of Selected Studies""; ""Appendix E Peroxisome Proliferators and Liver Cancer"" 330 $aTrichloroethylene is a chlorinated solvent widely used as a degreasing agent in industrial and manufacturing settings. It is also used as a chemical intermediate in making other chemicals and is a component of products such as typewriter correction fluid, paint removers, adhesives, and spot removers. In 2001, EPA issued a draft health risk assessment and proposed exposure standards for trichloroethylene. PA's Scientific Advisory Board (SAB) reviewed the draft and it was issued for public comment. A number of scientific issues were raised during the course of these reviews. Assessing the Human Health Risks of Trichloroethylene identifies and assesses the key scientific issues relevant to analyzing the human health risks of trichloroethylene, considering pertinent toxicologic, epidemiologic, population susceptibility, and other available information, including relevant published scientific literature, EPA's 2001 draft health risk assessment of trichloroethylene, scientific and technical comments received by EPA from public and private sources, and additional relevant information to be provided by the sponsoring agencies. This report highlights issues critical to the development of an objective, realistic, and scientifically balanced trichloroethylene health risk assessment. Guidance for hazard characterization of trichloroethylene is presented in Chapters 2 through 10. Chapter 2 provides guidance for evaluating large sets of epidemiologic data. In Chapter 3, the committee applies this guidance as an example in its evaluation of the epidemiologic data on trichloroethylene and kidney cancer, and this example should help guide evaluations of other cancer risks. Chapter 3 also assesses new information on the kidney toxicity of trichloroethylene and its metabolites and potential modes of action. Chapters 4, 5, 6, 7, and 8 evaluate the key issues regarding liver toxicity and cancer, reproductive and developmental toxicity, neurotoxicity, respiratory tract toxicity and cancer, and immunotoxicity, respectively. However, the committee's review focused on mode-of-action information to understand how trichloroethylene might affect certain processes differently in different species. Chapter 9 discusses susceptibility to trichloroethylene and its metabolites, and Chapter 10 describes important factors in considering trichloroethylene in mixtures. Physiologically based pharmacokinetic models are evaluated in Chapter 11, and guidance is provided on future directions for model development. Finally, Chapter 12 considers issues related to dose-response assessment and quantitative assessment of risk. 606 $aTrichloroethylene$xToxicology 606 $aTrichloroethylene$xEnvironmental aspects 615 0$aTrichloroethylene$xToxicology. 615 0$aTrichloroethylene$xEnvironmental aspects. 676 $a615.9/02 712 02$aNational Research Council (U.S.).$bCommittee on Human Health Risks of Trichloroethylene. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910968637603321 996 $aAssessing the human health risks of trichloroethylene$94471679 997 $aUNINA