LEADER 04205nam 2200589Ia 450 001 9910968574803321 005 20251117063228.0 010 $a1-60741-681-6 035 $a(CKB)1000000000786443 035 $a(EBL)3018579 035 $a(SSID)ssj0000119166 035 $a(PQKBManifestationID)11136320 035 $a(PQKBTitleCode)TC0000119166 035 $a(PQKBWorkID)10056820 035 $a(PQKB)11661823 035 $a(MiAaPQ)EBC3018579 035 $a(Au-PeEL)EBL3018579 035 $a(CaPaEBR)ebr10660440 035 $a(OCoLC)844348922 035 $a(BIP)22729398 035 $a(EXLCZ)991000000000786443 100 $a20080617d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCell differentiation of neoplastic cells originating in the oral and craniofacial regions /$fToshiyuki Kawakami, Hitoshi Nagatsuka 205 $a1st ed. 210 $aNew York $cNova Science$dc2009 215 $a1 online resource (66 p.) 300 $aDescription based upon print version of record. 311 08$a1-60456-932-8 320 $aIncludes bibliographical references (p. [43]-50) and index. 327 $aBiology of neoplasms -- Developmental biology of teeth -- Developmental oral craniofacial biology -- Mandibular bone and cartilage development -- Notch signaling in cell differentiation and development -- Cell differentiation in pathological conditions -- Odontogenic neoplasms -- Notch signaling in ameloblastomas and ameloblastic carcinomas -- Cell differentiation in odontogenic neoplasms -- Cell differentiation in neoplasms of bone and cartilage -- Cell differentiation in BMP-induced heterotopic osteogenesis conclusion. 330 $aDevelopment of the oral and craniofacial region is a complex and fascinating set of processes which require a sequential integration of numerous biological steps. For medical and dental doctors, interest is particularly high in this region, because it is composed of three blastoderms - ectoderm, mesoderm, and endoderm - as well as neural crest cells. There are many different types of neoplasms in this region. In general, proliferation, development and cytological differentiation of the neoplastic cells reflect the normal physiological development of the outbreak mother cells and/or tissues. Collected human neoplasm cases, such as osteosarcoma appearing in the oral and craniofacial region, are examined regarding the immunohistochemical expression of some morphogenesis regulation factors. Furthermore, examination of Notch signaling is also conducted for some odontogenic neoplasms. This book mainly describes the examination results of some morphogenesis regulation factors, such as Notch signaling, in the neoplastic cells originating in the oral and craniofacial region, especially in the odontogenic neoplasms, in both well-differentiated and poorly-differentiated neoplasms of tooth germ enamel organ-derived neoplasm. In general, these morphogenesis regulation factors are responsible for cytological regulation of cell fate, morphogenesis and/or development. The results suggest that these factors play some role in cytological differentiation or acquisition of tissue specific characteristics in neoplastic cells. Furthermore, there would appear to be a relationship between the cytological differentiation in the oral and craniofacial neoplastic cells and the physiological development and differentiation of their originating mother cells and tissues of the oral and craniofacial region. 606 $aMouth$xCancer$xHistopathology 606 $aHead$xCancer$xHistopathology 606 $aOdontogenic tumors$xHistopathology 615 0$aMouth$xCancer$xHistopathology. 615 0$aHead$xCancer$xHistopathology. 615 0$aOdontogenic tumors$xHistopathology. 676 $a616.99/431 700 $aKawakami$b Toshiyuki$01863760 701 $aNagatsuka$b Hitoshi$01863761 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910968574803321 996 $aCell differentiation of neoplastic cells originating in the oral and craniofacial regions$94470444 997 $aUNINA