LEADER 03500nam 2200721 a 450 001 9910968093403321 005 20250709215331.0 010 $a9781299276826 010 $a1299276822 010 $a9782842542375 010 $a2842542371 024 7 $a10.1051/978-2-84254-237-5 035 $a(CKB)2560000000099461 035 $a(EBL)3155343 035 $a(SSID)ssj0000906519 035 $a(PQKBManifestationID)11536131 035 $a(PQKBTitleCode)TC0000906519 035 $a(PQKBWorkID)10843950 035 $a(PQKB)10824750 035 $a(Au-PeEL)EBL3155343 035 $a(CaPaEBR)ebr10667713 035 $a(CaONFJC)MIL458932 035 $a(OCoLC)922991221 035 $a(DE-B1597)634993 035 $a(DE-B1597)9782842542375 035 $a(Au-PeEL)EBL7156049 035 $a(OCoLC)1355220062 035 $a(OCoLC)834607434 035 $a(PPN)176628622 035 $a(FRCYB88811388)88811388 035 $a(FR-PaCSA)88811388 035 $a(MiAaPQ)EBC3155343 035 $a(Perlego)3799206 035 $a(MiAaPQ)EBC7156049 035 $a(EXLCZ)992560000000099461 100 $a20241012d2012 u| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe clinibook $eclinical gene transfer : state of the art /$fedited by Odile Cohen-Haguenauer 205 $a1st ed. 210 $aParis $cEDP Sciences$d2012 215 $a1 online resource (589 p.) 300 $aDescription based upon print version of record. 311 08$a9782842541712 311 08$a2842541715 320 $aIncludes bibliographical references and index. 327 $apt. 1. Technologies and pre-clinical studies -- pt. 2. Clinical trials and regulatory issues. 330 $aThis book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation. 606 $aGenetic transformation 615 0$aGenetic transformation. 676 $a571.96 700 $aCohen-Haguenauer$b Odile, $4aut$4http://id.loc.gov/vocabulary/relators/aut$01087562 701 $aCohen-Haguenauer$b Odile$01087562 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910968093403321 996 $aThe clinibook$94355944 997 $aUNINA LEADER 03164nam 2200697Ia 450 001 9910955670603321 005 20251116175329.0 010 $a1-134-27247-2 010 $a1-280-25630-3 010 $a9786610256303 010 $a0-203-31526-X 035 $a(CKB)1000000000249269 035 $a(EBL)3060460 035 $a(SSID)ssj0000139684 035 $a(PQKBManifestationID)11146852 035 $a(PQKBTitleCode)TC0000139684 035 $a(PQKBWorkID)10028145 035 $a(PQKB)11510511 035 $a(MiAaPQ)EBC3060460 035 $a(Au-PeEL)EBL3060460 035 $a(CaPaEBR)ebr10155628 035 $a(CaONFJC)MIL25630 035 $a(OCoLC)62736643 035 $a(BIP)63758580 035 $a(BIP)50813802 035 $a(EXLCZ)991000000000249269 100 $a20040910d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDiscourse markers across languages $ea contrastive study of second-level discourse markers in native and non-native text with implications for general and pedagogic lexicography /$fDirk Siepmann 205 $a1st ed. 210 $aLondon $cRoutledge$d2005 215 $a1 online resource (346 p.) 225 1 $aRoutledge advances in corpus linguistics ;$v6 300 $aDescription based upon print version of record. 311 08$a1-138-86829-9 311 08$a0-415-34949-4 320 $aIncludes bibliographical references and index. 327 $a""Book cover""; ""Half-title""; ""Title""; ""Copyright""; ""Contents""; ""Preface""; ""Acknowledgements""; ""Part I: Linguistic considerations""; ""1. Observing languages""; ""2. Investigating routines""; ""3. Identifying meanings and functions""; ""4. Straddling cultures""; ""Part II: A contrastive interlanguage analysis with implications for dictionary making""; ""1. Introduction""; ""2. Facing realities""; ""3. Lexicographic treatment of SLDMs""; ""4. Avenues for further research""; ""Notes""; ""Bibliography""; ""Index"" 330 $aThis book offers a corpus-based comparative study of an almost entirely unexplored set of multi-word lexical items serving pragmatic or text-structuring functions. Part One provides a descriptive account of multi-word discourse markers in written English, French and German, focussing on dicussion of interlingual equivalence. Part Two examines the use of multi-word markers by non-native speakers of English and discusses lexicographical and pedagogical implications. 410 0$aRoutledge advances in corpus linguistics ;$v6. 606 $aDiscourse markers 606 $aContrastive linguistics 606 $aLexicography 606 $aLanguage and languages$xStudy and teaching 615 0$aDiscourse markers. 615 0$aContrastive linguistics. 615 0$aLexicography. 615 0$aLanguage and languages$xStudy and teaching. 676 $a401/.41 700 $aSiepmann$b Dirk$f1966-$0622701 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910955670603321 996 $aDiscourse markers across languages$91092870 997 $aUNINA