LEADER 04305nam 2200601 a 450 001 9910965857903321 005 20251117100833.0 010 $a1-61470-141-5 035 $a(CKB)2670000000370471 035 $a(EBL)3022260 035 $a(SSID)ssj0000873089 035 $a(PQKBManifestationID)12323834 035 $a(PQKBTitleCode)TC0000873089 035 $a(PQKBWorkID)10865586 035 $a(PQKB)11164118 035 $a(MiAaPQ)EBC3022260 035 $a(Au-PeEL)EBL3022260 035 $a(CaPaEBR)ebr10700437 035 $a(OCoLC)849929063 035 $a(BIP)34568714 035 $a(BIP)34568736 035 $a(EXLCZ)992670000000370471 100 $a20110510d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMotor neuron diseases $ecauses, classification and treatments /$fBradley J. Turner and Julie D. Atkin, editors 205 $a1st ed. 210 $aNew York $cNova Science Publishers$dc2012 215 $a1 online resource (248 p.) 225 1 $aNeurology--laboratory and clinical research developments 300 $a"Nova biomedical." 311 08$a1-61470-101-6 320 $aIncludes bibliographical references and index. 327 $aMotor neuron disease : causes, classification and treatments / Louisa Ng, Fary Khan -- Membrane trafficking defects as determinants of motor neuron susceptibility and degeneration in ALS / Bradley J. Turner, Julie D. Atkin -- Motoneuron specific calcium dysregulation and perturbed cellular calcium homestasis in amyotrophic lateral sclerosis : recent advances gained from genetically modified animals and cell culture models / Manoj Kumar Jaiswal -- Treatment of ALS utilizing a stem cell strategy / Xiufang Guo, James J. Hickman -- Tdp-43-immunoreactive pathology in frontotemporal lobar degeneration with TDP proteinopathy (FTLD-TDP) with and without associated motor neuron disease (MND) / R.A. Armstrong -- Excitotoxicity and selective motor neuron degeneration / K.A. Staats, L. Van Den Bosch -- Stem cell application in amyotrophic lateral sclerosis : growth factor delivery and cell therapy / Ksenija Bernau, Michael G. Meyer, Masatoshi Suzuki -- Therapeutic intervention in spinal and bulbar muscular atrophy (SBMA) / Haruhiko Banno ... [et al.] -- Expert commentary : motor neuron disease : assistive technology / Louisa Ng, Fary Khan -- Comparative study on application of invasive ventilation and non-invasive ventilation to ALS patients in Europe, the USA, and Japan / Rika Yamauchi, Jun Kawamata, Shun Shimohama -- Motor speech disorder in patients with motor neuron disease / Hideto Saigusa -- Non-viral gene delivery of the GDNF, either alone or fused to the C-fragment of tetanus toxin protein, prolongs survival in a mouse ALS model / Rosario Osta -- Motor neuron disease / Kazumi Murai -- Motor neuron disease / Anil Kumar -- Bulbospinal muscular atrophy (BSMA) Kennedy's disease / J. Finsterer. 330 $aMotor neuron disease (MND), also commonly known as amyotrophic lateral sclerosis (ALS), is a chronic neurodegenerative disorder of the motor system in adults, characterized by the loss of motor neurons in the cortex, brain stem and spinal cord. This book presents current research from across the globe in the study of the causes, classification and treatments of MND, including membrane trafficking defects as determinants of motor neuron susceptibility and degeneration in ALS; motorneuron specific calcium dysregulation and perturbed cellular calcium homeostasis in ALS; stem cells and their application in ALS treatment; excitotoxicity and selective motor neuron degeneration and therapeutic invervention and assistive technology treatments. (Imprint: Nova Biomedical) 410 0$aNeurology--laboratory and clinical research development series. 606 $aAmyotrophic lateral sclerosis 606 $aMotor neurons$xDiseases 615 0$aAmyotrophic lateral sclerosis. 615 0$aMotor neurons$xDiseases. 676 $a616.8/39 701 $aTurner$b Bradley James$01866615 701 $aAtkin$b Julie$01866616 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910965857903321 996 $aMotor neuron diseases$94474028 997 $aUNINA