LEADER 04479nam 2200865Ia 450 001 9910965379503321 005 20251017110058.0 010 $a9786610179428 010 $a9780309166775 010 $a0309166772 010 $a9781280179426 010 $a1280179422 010 $a9780309527200 010 $a0309527201 035 $a(CKB)111087027008986 035 $a(OCoLC)54770887 035 $a(CaPaEBR)ebrary10051648 035 $a(SSID)ssj0000257443 035 $a(PQKBManifestationID)11216533 035 $a(PQKBTitleCode)TC0000257443 035 $a(PQKBWorkID)10228879 035 $a(PQKB)11356227 035 $a(Au-PeEL)EBL3564030 035 $a(CaPaEBR)ebr10051648 035 $a(MiAaPQ)EBC3564030 035 $a(Perlego)4730927 035 $a(DNLM)1199310 035 $a(BIP)9445274 035 $a(EXLCZ)99111087027008986 100 $a20031202d2004 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTestosterone and aging $eclinical research directions /$fCommittee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy, Board on Health Sciences Policy ; Catharyn T. Liverman and Dan G. Blazer, editors 205 $a1st ed. 210 $aWashington, DC $cNational Academies Press$dc2004 215 $a1 online resource (xvii, 219 pages) $cillustrations 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$aPrint version: Testosterone and aging. Washington, DC : National Academies Press, ©2004 0309090636 (DLC) 2003026323 (OCoLC)53840363 311 08$a9780309090636 311 08$a0309090636 320 $aIncludes bibliographical references. 327 $aFrontMatter -- Independent Report Reviewers -- Preface -- Acknowledgments -- Contents -- Tables, Figures, and Boxes -- Executive Summary -- 1 Introduction -- 2 Testosterone and Health Outcomes -- 3 Future Research Directions -- 4 Concluding Remarks -- Appendixes -- A Data Sources and Methods -- B Randomized Placebo-Controlled Trials of Testosterone Therapy in Older Men -- C Additional Studies of Testosterone Therapy -- D Testosterone Levels in Clinical Studies -- E Acronyms -- F Biographical Sketches of Committee Members and Staff -- Index. 330 $aPopular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an oeantiaging tonic, testosterone (TM)s reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular there has been growing concern about an increase in the number of middle-aged and older men using testosterone and the lack of scientific data on the effect it may have on aging males. Studies of testosterone replacement therapy in older men have generally been of short duration, involving small numbers of participants and often lacking adequate controls. Testosterone and Aging weighs the options of future research directions, examines the risks and benefits of testosterone replacement therapy, assesses the potential public health impact of such therapy in the United States, and considers ethical issues related to the conduct of clinical trials. Testosterone therapy remains an attractive option to many men even as speculation abounds regarding its potential. 606 $aLongevity 606 $aAging$xPrevention 606 $aTestosterone$xPhysiological effect 606 $aOlder people 606 $aAging$xdrug effects 606 $aAged 606 $aLongevity 606 $aTestosterone$xphysiology 606 $aTestosterone$xtherapeutic use 615 0$aLongevity. 615 0$aAging$xPrevention. 615 0$aTestosterone$xPhysiological effect. 615 0$aOlder people. 615 12$aAging$xdrug effects. 615 2$aAged. 615 2$aLongevity. 615 22$aTestosterone$xphysiology. 615 22$aTestosterone$xtherapeutic use. 676 $a612.6/8 701 $aLiverman$b Catharyn T$01086332 701 $aBlazer$b Dan G.$cII$g(Dan German),$f1944-$01813229 712 02$aNational Research Council (U.S.).$bCommittee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910965379503321 996 $aTestosterone and aging$94477382 997 $aUNINA