LEADER 02058nam 2200469Ia 450 001 996385346203316 005 20200824132556.0 035 $a(CKB)4940000000073526 035 $a(EEBO)2240898100 035 $a(OCoLC)ocm11770692e 035 $a(OCoLC)11770692 035 $a(EXLCZ)994940000000073526 100 $a19850306d1691 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 04$aThe works of Ambrose Parey chyrurgeon to Henry II, Francis II, Charles IX, and Henry III, Kings of France$b[electronic resource] $ewherein are contained, an introduction to chirurgery in general : a discourse of animals and the excellence of man : the anatomy of man's body : a treatise of praeternatural tumors ... /$fillustrated with variety of figures and the cuts of the most useful instruments in chirurgery : recommended by the University of Paris to all students in physick and chirurgery .. 210 $aLondon $cPrinted and sold by Jos. Hindmarsh ...$dMDCXCI [1691] 215 $a[20], 713, [4], 44, [17] p. $cill., plates 300 $a"To the reader" signed: Thomas Johnson. 300 $aNumerous errors in pagination. 300 $a"Aggeiologia, or, A description of the vessels in the body of man" by Adrian van de Siegel has special t.p. and separate pagination. 300 $aReproduction of original in the Harvard University Library. 330 $aeebo-0062 606 $aMedicine$vEarly works to 1800 606 $aSurgery$vEarly works to 1800 606 $aHuman anatomy$vEarly works to 1800 615 0$aMedicine 615 0$aSurgery 615 0$aHuman anatomy 700 $aPare?$b Ambroise$f1510?-1590.$0387604 701 $aSpiegel$b Adriaan van de$f1578-1625.$0972514 801 0$bEAJ 801 1$bEAJ 801 2$bUMI 801 2$bOCL 801 2$bm/c 801 2$bUMI 801 2$bWaOLN 906 $aBOOK 912 $a996385346203316 996 $aThe works of Ambrose Parey chyrurgeon to Henry II, Francis II, Charles IX, and Henry III, Kings of France$92320922 997 $aUNISA LEADER 05467nam 22007214a 450 001 9910964871903321 005 20200520144314.0 010 $a9786612117534 010 $a9781282117532 010 $a128211753X 010 $a9781444311280 010 $a144431128X 035 $a(CKB)1000000000719771 035 $a(EBL)428059 035 $a(OCoLC)476272225 035 $a(SSID)ssj0000364736 035 $a(PQKBManifestationID)11268001 035 $a(PQKBTitleCode)TC0000364736 035 $a(PQKBWorkID)10399033 035 $a(PQKB)11726039 035 $a(MiAaPQ)EBC428059 035 $a(Au-PeEL)EBL428059 035 $a(CaPaEBR)ebr10304025 035 $a(CaONFJC)MIL211753 035 $a(Perlego)2766282 035 $a(EXLCZ)991000000000719771 100 $a20020427d2003 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPrinciples of genome analysis and genomics /$fSandy B. Primrose, Richard M. Twyman 205 $a3rd ed. 210 $aMalden, Mass. $cBlackwell Pub.$d2003 215 $a1 online resource (272 p.) 300 $aDescription based upon print version of record. 311 08$a9781405101202 311 08$a1405101202 320 $aIncludes bibliographical references (p. [230]-254) and index. 327 $aPreface; Abbreviations; CHAPTER 1 Setting the scene: the new science of genomics; Introduction; Physical mapping of genomes; Sequencing whole genomes; Benefits of genome sequencing; Outline of the rest of the book; Terminology; Keeping up to date; Suggested reading; Useful websites; CHAPTER 2 The organization and structure of genomes; Introduction; Genome size; Sequence complexity; Introns and exons; Genome structure in viruses and prokaryotes; The organization of organelle genomes; The organization of nuclear DNA in eukaryotes; Suggested reading; Useful websites 327 $aCHAPTER 3 Subdividing the genome Introduction; Fragmentation of DNA with restriction enzymes; Separating large fragments of DNA; Isolation of chromosomes; Chromosome microdissection; Vectors for cloning DNA; Yeast artificial chromosomes; P1-derived and bacterial artificial chromosomes as alternatives to yeast artificial chromosomes; Retrofitting; Choice of vector; Suggested reading; Useful website; CHAPTER 4 Assembling a physical map of the genome; Introduction; Restriction enzyme fingerprinting; Marker sequences; Hybridization assays; Physical mapping without cloning 327 $aIntegration of different mapping methods Suggested reading; Useful websites; CHAPTER 5 Sequencing methods and strategies; Basic DNA sequencing; Modifications of chain-terminator sequencing; Automated DNA sequencing; DNA sequencing by capillary array electrophoresis; Base calling and sequence accuracy; High throughput sequencing; Sequencing strategies; Alternative DNA sequencing methodologies; Suggested reading; Useful websites; CHAPTER 6 Genome annotation and bioinformatics; Introduction; Traditional routes to gene identification; Databases; Overview of sequence analysis 327 $aDetecting open-reading frames Software programs for finding genes; Using homology to find genes; Analysis of non-coding RNA and extragenic DNA; Identifying the function of a new gene; Secondary databases of functional domains; Gene ontology; Analyses not based on homology; Genome annotation; Molecular phylogenetics; Suggested reading; Useful websites; CHAPTER 7 Comparative genomics; Introduction; Orthologues,paralogues and gene displacement; Protein evolution by exon shuffing; Comparative genomics of prokaryotes; Comparative genomics of organelles; Comparative genomics of eukaryotes 327 $aOther aspects of comparative genomics Suggested reading; Useful websites; CHAPTER 8 Protein structural genomics; Introduction; Determining gene function by sequence comparison; Determining gene function through conserved protein structure; Approaches to protein structural genomics; Suggested reading; Useful website; CHAPTER 9 Global expression pro ling; Introduction; Traditional approaches to expression pro ling; Global analysis of RNA expression; Global analysis of protein expression; Suggested reading; Useful websites; CHAPTER 10 Comprehensive mutant libraries; Introduction 327 $aHigh-throughput systematic gene knockout 330 $aWith the first draft of the human genome project in the public domain and full analyses of model genomes now available, the subject matter of 'Principles of Genome Analysis and Genomics' is even 'hotter' now than when the first two editions were published in 1995 and 1998. In the new edition of this very practical guide to the different techniques and theory behind genomes and genome analysis, Sandy Primrose and new author Richard Twyman provide a fresh look at this topic. In the light of recent exciting advancements in the field, the authors have completely revised and rewritten many parts of 606 $aGene mapping 606 $aNucleotide sequence 606 $aGenomics 615 0$aGene mapping. 615 0$aNucleotide sequence. 615 0$aGenomics. 676 $a572.8/633 700 $aPrimrose$b S. B$0286135 701 $aTwyman$b Richard M$0286136 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910964871903321 996 $aPrinciples of genome analysis and genomics$94362325 997 $aUNINA