LEADER 04721nam 2200721 a 450 001 9910963970003321 005 20240516144822.0 010 $a3-11-026037-9 024 7 $a10.1515/9783110260373 035 $a(CKB)2670000000328236 035 $a(EBL)893175 035 $a(OCoLC)826482554 035 $a(SSID)ssj0000819052 035 $a(PQKBManifestationID)11463154 035 $a(PQKBTitleCode)TC0000819052 035 $a(PQKBWorkID)10844224 035 $a(PQKB)10951172 035 $a(DE-B1597)171778 035 $a(OCoLC)880404765 035 $a(OCoLC)948656048 035 $a(DE-B1597)9783110260373 035 $a(Au-PeEL)EBL893175 035 $a(CaPaEBR)ebr10649214 035 $a(Perlego)404190 035 $a(MiAaPQ)EBC893175 035 $a(EXLCZ)992670000000328236 100 $a20120801d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aKallikrein-related peptidases$hVolume 1$iCharacterization, regulation, and interactions within the protease web /$fViktor Magdolen ... [et al.], editors 205 $a1st ed. 210 $aBerlin $cWalter de Gruyter$dc2012 215 $a1 online resource (428 p.) 225 0 $aKallikrein-related peptidases ;$vVolume 1 300 $aDescription based upon print version of record. 311 08$a3-11-048151-0 311 08$a3-11-026036-0 320 $aIncludes bibliographical references and index. 327 $aGenomic structure of the KLK locus -- Single nucleotide polymorphisms in the human KLK locus and their implication in various diseases -- Evolution of Kallikrein-related peptidases -- Structural aspects of Kallikrein-related peptidases -- Molecular recognition properties of Kallikrein-related peptidases on synthetic and endogenous substrates -- Natural, engineered, and synthetic inhibitors of Kallikrein-related peptidases -- Kallikrein-related peptidases as pharmaceutical targets -- Expression of Kallikrein-related peptidases under (patho) physiological conditions -- Kallikrein-related peptidases within the proteolytic web -- Kallikrein-Kinin cascade: bioregulation by human tissue kallikrein 1 (HK1, KLK 1) -- Role of KLK4 in dental enamel formation. 327 $aKallikrein-related peptidases and semen -- Kallikrein-related peptidases and inhibitors of the skin -- Physiological and pathophysiological roles of Kallikrein-related peptidases in the central nervous system -- Kallikrein-related peptidases (KLKS), proteinase-mediated signaling and proteinase-activated receptors (PARS) -- Pathophysiology of Kallikrein-related peptidases in lung cancer -- Clinical relevance of Kallikrein-related peptidases in gastric and colorectal cancer -- Pathophysiology of Kallikrein-related peptidases in head and neck cancer -- PSA (prostate-specific antigen) and other Kallikrein-related peptidases in prostate cancer -- Cellular model systems to study the tumor biological role of Kallikrein-related peptidases in ovarian and prostate cancer -- Clinical relevance of Kallikrein-related peptidases in breast cancer -- Clinical relevance of Kallikrein-related peptidases in ovarian cancer -- MicroRNAs : a new control mechanism for Kallikrein-related peptidases in kidney and other cancers -- Genomic instability of the KLK-locus in cancer -- Kallikrein-related peptidases as biomarkers in personalized cancer medicine. 330 $aThis handbook is the first comprehensive book of its kind reviewing the clinically relevant current status of tissue kallikrein and kallikrein-related peptidases research. Since several members of the KLK family are key players in (patho-)physiological processes, structural, functional, and regulatory studies are under way to develop new strategies to prevent and treat disorders to which individual members of the KLK protease family contribute significantly. The goal of this book is to inform clinicians, physician scientists and researchers about the prominent role of the multifaceted and interactive KLK system in normal physiology and pathological organ function. 606 $aKallikrein$xGenetics 606 $aKallikrein$xMetabolism 606 $aTumors$xGenetics 606 $aProteolytic enzymes$xMetabolism 615 0$aKallikrein$xGenetics. 615 0$aKallikrein$xMetabolism. 615 0$aTumors$xGenetics. 615 0$aProteolytic enzymes$xMetabolism. 676 $a616.99/4042 676 $a572.4 686 $aWD 5065$2rvk 701 $aMagdolen$b Viktor$01852432 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910963970003321 996 $aKallikrein-related peptidases$94447562 997 $aUNINA LEADER 03574oam 2200589I 450 001 9910970503803321 005 20251117000508.0 010 $a0-429-97395-0 010 $a0-429-96287-8 010 $a0-429-49432-7 010 $a1-78539-785-0 010 $a0-8133-4919-2 024 7 $a10.4324/9780429494321 035 $a(CKB)3710000000445723 035 $a(EBL)1181621 035 $a(SSID)ssj0001517961 035 $a(PQKBManifestationID)12565185 035 $a(PQKBTitleCode)TC0001517961 035 $a(PQKBWorkID)11509182 035 $a(PQKB)10350983 035 $a(MiAaPQ)EBC1181621 035 $a(OCoLC)1029246932 035 $a(EXLCZ)993710000000445723 100 $a20180706d2016 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe U.S. intelligence community /$fJeffrey T. Richelson 205 $a7th ed. 210 1$aBoulder, CO :$cWestview Press,$d[2016] 215 $a1 online resource (649 p.) 300 $aIncludes index. 311 08$a0-367-09795-8 311 08$a0-8133-4918-4 327 $aLIST OF ILLUSTRATIONS; PREFACE; 1: INTELLIGENCE; 2: NATIONAL INTELLIGENCE ORGANIZATIONS; 3: DEFENSE DEPARTMENT INTELLIGENCE:THE DEFENSE INTELLIGENCE AGENCY; 4: MILITARY SERVICE INTELLIGENCE ORGANIZATIONS; 5: CIVILIAN DEPARTMENTAL INTELLIGENCE ORGANIZATIONS; 6: UNIFIED COMMAND INTELLIGENCE ORGANIZATIONS; 7: GEOSPATIAL INTELLIGENCE COLLECTION, PROCESSING, EXPLOITATION, ANDDISSEMINATION; 8: SIGNALS INTELLIGENCE AND CYBER COLLECTION; 9: MEASUREMENT AND SIGNATURE INTELLIGENCE; 10: SPACE SURVEILLANCE; 11: HUMAN INTELLIGENCE; 12: OPEN SOURCES, SITE EXPLOITATION, AND FOREIGN MATERIEL ACQUISITION 327 $a13: COOPERATION WITH FOREIGN SERVICES14: ANALYSIS; 15: COUNTER INTELLIGENCE; 16: COVERT ACTION; 17: MANAGING NATIONAL INTELLIGENCE; 18: MANAGING DEFENSE INTELLIGEN; 19: MANAGING INTELLIGENCE COLLECTION,COVERT ACTION, AND INFORMATION ACCESS; 20: ISSUES; ACRONYMS AND ABBREVIATIONS; INDEX 330 $a"The role of intelligence in U.S. government operations has changed dramatically and is now more critical than ever to domestic security and foreign policy. This authoritative and highly researched book written by Jeffrey T. Richelson provides a detailed overview of America's vast intelligence empire, from its organizations and operations to its management structure. Drawing from a multitude of sources, including hundreds of official documents, The U.S. Intelligence Community allows students to understand the full scope of intelligence organizations and activities, and gives valuable support to policymakers and military operations. The seventh edition has been fully revised and updated to include revamped chapters on signals intelligence and cyber collection, geospatial intelligence, and open sources and exploitation. The inclusion of more maps, tables and photos makes it an even more valuable and engaging resource for students. In addition, a new web site provides access to the documents referenced in the book and suggestions for supplementary case studies"--$cProvided by publisher. 517 1 $aUS intelligence community 606 $aIntelligence service$zUnited States 615 0$aIntelligence service 676 $a383.12094589 686 $aPOL036000$aPOL012000$aPOL030000$2bisacsh 700 $aRichelson$b Jeffrey$0473445 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910970503803321 996 $aUS intelligence community$9226904 997 $aUNINA