LEADER 05834nam 2200757Ia 450 001 9910963356103321 005 20250605210125.0 010 $a0-19-803145-9 010 $a9786610834624 010 $a1-280-83462-5 035 $a(CKB)2560000000296687 035 $a(EBL)281380 035 $a(OCoLC)476026344 035 $a(SSID)ssj0000200172 035 $a(PQKBManifestationID)11204143 035 $a(PQKBTitleCode)TC0000200172 035 $a(PQKBWorkID)10196842 035 $a(PQKB)10562750 035 $a(StDuBDS)EDZ0000023780 035 $a(MiAaPQ)EBC281380 035 $a(Au-PeEL)EBL281380 035 $a(CaPaEBR)ebr10269190 035 $a(CaONFJC)MIL83462 035 $a(MiAaPQ)EBC7038642 035 $a(Au-PeEL)EBL7038642 035 $a(EXLCZ)992560000000296687 100 $a20001027d2001 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMechanisms of synaptic transmission $ebridging the gaps (1890-1990) /$fJoseph D. Robinson 210 $aOxford ;$aNew York $cOxford University Press$d2001 215 $a1 online resource (xiv, 451 pages) $cillustrations 300 $aDescription based upon print version of record. 311 08$a0-19-513761-2 311 08$a0-19-984816-5 320 $aIncludes bibliographical references (p. 359-442) and index. 327 $aContents; 1. Beginnings: Cajal and the Neuron Theory (1889-1909); Cajal at Berlin; Background: Cells, Nerve Cells, and Nerve Impulses; Proclamation of the Neuron Theory; Cajal's Contributions; Confirmations, Criticisms, and Responses; Conclusions; 2. Beginnings: Sherrington and the Synapse (1890-1913); Sherrington, Reflexes, and the Synapse; Background: Reflexes; Sherrington's Achievements; Synapses and the Reflex Arc; Conclusions; 3. Chemical Transmission at Synapses (1895-1945); Nerve Impulse Conduction and Synapse Structure; Background: The Autonomic Nervous System 327 $aChemical Transmission in the Autonomic Nervous SystemChemical Transmission at Neuromuscular Junctions; Chemical Transmission in the Central Nervous System; Electrical Transmission; Conclusions; 4. Chemical Transmission at Synapses (1945-1965); Postwar Progress; Identifying Chemical Transmission; Visualizing Synaptic Gaps and Synaptic Vesicles; Identifying Electrical Transmission; Conclusions; 5. Identifying Neurotransmitters (1946-1976); Scope and Criteria; Acetylcholine; Noradrenaline; Dopamine; Serotonin; GABA; Glutamate; Glycine; Neuropeptides: Substance P and Enkephalins; Conclusions 327 $a6. Characterizing Receptors (1905-1983)Essential Issues; Drug-Receptor Interactions; Receptor Classification; Structure-Activity Relationships; Receptor Identification and Purification; Responses of Individual Receptor Molecules; Conclusions; 7. Second Messengers (1951-1990); Cyclic AMP; Protein Kinases and Phosphatases; G-Proteins; Ca[sup(2+)]; Inositol-trisphosphate and Diacylglycerol; Conclusions; 8. Receptor Structures and Receptor Families (1983-1990); Molecular Biology and Recombinant DNA Techniques; Nicotinic Cholinergic Receptors; Ligand-Gated Ion Channels; Adrenergic Receptors 327 $aG-Protein Coupled ReceptorsReceptor Regulation; Conclusions; 9. Synthesis, Storage, Transport, and Metabolic Degradation of Neurotransmitters; Steps in Chemical Transmission; Synthesis; Storage; Degradation; Transport (""Reuptake""); Conclusions; 10. Neurotransmitter Release; Proposals; Evidence for Exocytotic Release; Triggering of Release; Mechanism of Release; Endocytotic Retrieval of Vesicles; Ca[sup(2+)]-Independent Non-Exocytotic Release; Conclusions; 11. Formation of Specific Synapses; Embryonic Development of Synaptic Connections; Approaches and Possible Mechanisms 327 $aEarly Arguments Concerning Chemotaxis (1890-1963)Cell Death and Neurotrophic Factors; Chemical Guidance (1963-1990); Growth Cone Motility; Synapse Formation; Conclusions; 12. Learning; Background; Chemical Representations; Learning in Aplysia; Learning in Drosophila; Learning in Mammals: The Hippocampus and Long-Term Potentiation (LTP); Conclusions; 13. Diseases and Therapies; Defining and Developing; Parkinson's Disease; Schizophrenia; Depression and Manic-Depressive Illness; Conclusions; 14. Epilogue; Progress; Historical Accounts and Conclusions; Assumptions; Approaches; Goals 327 $aGeneralities and Exceptions 330 $aThis book describes a century of research on how nerve cells communicate with one another, beginning with the formulation of the Neuron Theory and proceeding through studies embracing a broad range of disciplines. The Neuron Theory initially depicted discrete nerve cells interacting at their points of contact (""synapses""); since nerve impulse were often indentified as electrical signals traveling along neuronal processes, it seemed plausible that impulses would also pass from cell to electrically. Over the next hundred years, however, ingenious experiments, facilitated by powerful new techni 517 3 $aBridging the gaps (1890-1990) 606 $aNeural transmission$xResearch$xHistory$y20th century 606 $aSynapses$xResearch$xHistory$y20th century 606 $aSynaptic Transmission$xphysiology$3(DNLM)D009435Q000502 606 $aResearch$xhistory$3(DNLM)D012106Q000266 615 0$aNeural transmission$xResearch$xHistory 615 0$aSynapses$xResearch$xHistory 615 12$aSynaptic Transmission$xphysiology. 615 12$aResearch$xhistory. 676 $a573.809 676 $a573.85 676 $a612.8 700 $aRobinson$b Joseph D.$01824799 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910963356103321 996 $aMechanisms of synaptic transmission$94392133 997 $aUNINA