LEADER 04723nam 2200649Ia 450 001 9910962841403321 005 20251116175016.0 010 $a9786611872311 010 $a9781281872319 010 $a1281872318 010 $a9789812562340 010 $a9812562346 035 $a(CKB)1000000000247258 035 $a(StDuBDS)AH21190555 035 $a(SSID)ssj0000225591 035 $a(PQKBManifestationID)11910983 035 $a(PQKBTitleCode)TC0000225591 035 $a(PQKBWorkID)10231308 035 $a(PQKB)11643858 035 $a(MiAaPQ)EBC1681757 035 $a(WSP)00005547 035 $a(Au-PeEL)EBL1681757 035 $a(CaPaEBR)ebr10104118 035 $a(CaONFJC)MIL187231 035 $a(OCoLC)815742847 035 $a(Perlego)849697 035 $a(BIP)10858095 035 $a(EXLCZ)991000000000247258 100 $a20040830d2004 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe practical bioinformatician /$feditor, Limsoon Wong 205 $a1st ed. 210 $aRiver Edge, N.J. ;$aLondon $cWorld Scientific$dc2004 215 $axxii, 517 p. $cill. (some col.), ports 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a9789812388469 311 08$a981238846X 320 $aIncludes bibliographical references (p. 457-509). 327 $aChapter 1. Molecular Biology for the Practical Bioinformatician -- Chapter 2. Strategy and Planning of Bioinformatics Experiments -- Chapter 3. DataMining Techniques for the Practical Bioinformatician -- Chapter 4. Techniques for Recognition of Translation Initiation Sites -- Chapter 5. How Neural Networks Find Promoters Using Recognition of Micro-Structural Promoter Components -- Chapter 6. Neural-StatisticalModel of TATA-Box Motifs in Eukaryotes -- Chapter 7. Tuning the Dragon Promoter Finder System for Human Promoter Recognition -- Chapter 8. RNA Secondary Structure Prediction -- Chapter 9. Protein Localization Prediction -- Chapter 10. Homology Search Methods -- Chapter 11. Analysis of Phylogeny: A Case Study on Saururaceae -- Chapter 12. Functional Annotation and Protein Families: From Theory to Practice -- Chapter 13. Discovering Protein-Protein Interactions -- Chapter 14. Techniques for Analysis of Gene Expression -- Chapter 15. Genome-Wide cDNA Oligo Probe Design and its Applications in Schizosaccharomyces Pombe -- Chapter 16. Mining New Motifs from cDNA Sequence Data -- Chapter 17. Technologies for Biological Data Integration -- Chapter 18. Construction of Biological Databases: A Case Study on the Protein Phosphatase DataBase (PPDB) -- Chapter 19. A Family Classification Approach to Functional Annotation of Proteins -- Chapter 20. Informatics for Efficient EST-Based Gene Discovery in Normalized and Subtracted cDNA Libraries. 330 $a Computer scientists have increasingly been enlisted as "bioinformaticians" to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics: - Overview of modern molecular biology and a broad spectrum of techniques from computer science -- data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc. - In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences. - Incisive discussion of computational prediction of secondary structure of RNA sequences. - Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function. - Overview of methods for discovering protein-protein interactions. - Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions. - Case studies on analysis of phylogenies, functional annotation of proteins, construction of purpose-built integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery. 606 $aComputational biology 606 $aBioinformatics 615 0$aComputational biology. 615 0$aBioinformatics. 676 $a572.86330285 701 $aWong$b Limsoon$f1965-$01650161 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910962841403321 996 $aThe practical bioinformatician$94474561 997 $aUNINA