LEADER 05514nam 2200757Ia 450 001 9910962017103321 005 20251017110053.0 010 $a9786610192670 010 $a9780309176118 010 $a0309176115 010 $a9781280192678 010 $a1280192674 010 $a9780309588485 010 $a0309588480 010 $a9780585143354 010 $a0585143358 035 $a(CKB)110986584751684 035 $a(SSID)ssj0000099471 035 $a(PQKBManifestationID)11108345 035 $a(PQKBTitleCode)TC0000099471 035 $a(PQKBWorkID)10007304 035 $a(PQKB)11063294 035 $a(MiAaPQ)EBC3376211 035 $a(Au-PeEL)EBL3376211 035 $a(CaPaEBR)ebr10055209 035 $a(OCoLC)923261963 035 $a(Perlego)4735098 035 $a(DNLM)797920 035 $a(BIP)47022121 035 $a(EXLCZ)99110986584751684 100 $a19950802d1995 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAdverse reproductive outcomes in families of atomic veterans $ethe feasibility of epidemiologic studies /$fCommittee to Study the Feasibility of, and Need for, Epidemiologic Studies of Adverse Reproductive Outcomes in the Families of Atomic Veterans, Medical Follow-up Agency, Institute of Medicine 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1995 215 $ax, 97 p 300 $a"Support for this project was provided by the Department of Veterans Affairs (contract no. V101-(93)P-1469)"--T.p. verso. 311 08$a9780309053402 311 08$a0309053404 320 $aIncludes bibliographical references (p. 91-97). 327 $aAdverse Reproductive Outcomes in Families of Atomic Veterans: The Feasibility of Epidemiologic Studies -- Copyright -- Preface -- Contents -- Executive Summary -- CONCLUSIONS -- ORGANIZATION AND FRAMEWORK OF THE REPORT -- ADVERSE REPRODUCTIVE OUTCOMES -- ESTIMATION OF GENETIC RISK -- FEASIBILITY OF AN EPIDEMIOLOGIC STUDY -- Question 1. Definition of the Study Sample -- Question 2. Sample Size -- Question 3. Dose -- Question 4. Identification of Adverse Reproductive Outcomes -- ALTERNATIVE APPROACHES -- 1 Introduction -- AIMS OF THIS REPORT -- 2 Basic Epidemiologic Issues -- 3 Feasibility and Design of an Epidemiologic Study -- STUDY COHORT -- MEASUREMENT OF EXPOSURE -- DEFINING THE DISEASE AND ASCERTAINING THE CASES -- 4 Basic Principles of Radiation Biology -- BIOLOGICAL EFFECTS -- SOURCES OF RADIATION EXPOSURE -- POTENTIALLY SENSITIVE SUBGROUPS -- 5 Genetic Principles and Issues -- 6 Current Knowledge and Estimation of Genetic Risk -- BASIC ESTIMATION EQUATION -- DATA FROM WHICH RISK ESTIMATES HAVE BEEN MADE -- Mice -- Humans -- Estimating the Spontaneous Burden -- Estimating the Effect of Ionizing Radiation -- ESTIMATING THE DOUBLING DOSE -- Mice -- Humans -- 7 Adverse Reproductive Outcomes -- GENERAL REMARKS -- MALE-MEDIATED REPRODUCTIVE AND DEVELOPMENTAL OUTCOMES -- INFERTILITY -- Radionuclide Irradiation -- SPONTANEOUS ABORTIONS -- PRETERM DELIVERY -- STILLBIRTHS AND NEONATAL DEATHS (PERINATAL DEATHS) -- BIRTH DEFECTS -- Human Chromosome Abnormalities -- Developmental Abnormalities -- MATERNAL ILLNESSES -- ALTERED SEX RATIO -- MORTALITY AMONG THE CHILDREN OF EXPOSED PARENTS -- CANCER AND LEUKEMIA IN PARTICULAR -- IMMUNE DEFICIENCY -- NEUROLOGIC DEFICIT, INCLUDING MENTAL RETARDATION -- 8 Feasibility of the Study of Adverse Reproductive Outcomes in the Families of Veterans Exposed Ionizing Radiation. 327 $aDEFINITION OF A SUITABLE SAMPLE OR COHORT -- SIZE OF THE SAMPLE OR COHORT REQUIRED -- Question 1 -- Question 2 -- DOSIMETRY OF ATOMIC VETERANS -- IDENTIFICATION OF ADVERSE REPRODUCTIVE OUTCOMES -- 9 Alternative Approaches -- 10 Conclusions -- Glossary -- References. 330 $aOver the past several decades, public concern over exposure to ionizing radiation has increased. This concern has manifested itself in different ways depending on the perception of risk to different individuals and different groups and the circumstances of their exposure. One such group are those U.S. servicemen (the "Atomic Veterans" who participated in the atmospheric testing of nuclear weapons at the Nevada Test Site or in the Pacific Proving Grounds, who served with occupation forces in or near Hiroshima and Nagasaki, or who were prisoners of war in or near those cities at the time of, or shortly after, the atomic bombings. This book addresses the feasibility of conducting an epidemiologic study to determine if there is an increased risk of adverse reproductive outcomes in the spouses, children, and grandchildren of the Atomic Veterans. 606 $aRadiation$xPhysiological effect 606 $aVeterans$xDiseases 606 $aRadiation victims 606 $aTeratogenesis 606 $aAbnormalities, Human 615 0$aRadiation$xPhysiological effect. 615 0$aVeterans$xDiseases. 615 0$aRadiation victims. 615 0$aTeratogenesis. 615 0$aAbnormalities, Human. 676 $a616/.043 712 02$aInstitute of Medicine (U.S.).$bCommittee to Study the Feasibility of, and Need for, Epidemiologic Studies of Adverse Reproductive Outcomes in the Families of Atomic Veterans. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910962017103321 996 $aAdverse reproductive outcomes in families of atomic veterans$94357776 997 $aUNINA