LEADER 06406nam 2200793 a 450 001 9910961798603321 005 20251116140713.0 010 $a9786610211043 010 $a9780309176835 010 $a0309176832 010 $a9781280211041 010 $a1280211040 010 $a9780309587136 010 $a0309587131 010 $a9780585002392 010 $a0585002398 035 $a(CKB)110986584751472 035 $a(OCoLC)42328527 035 $a(CaPaEBR)ebrary10055146 035 $a(SSID)ssj0000232124 035 $a(PQKBManifestationID)11226068 035 $a(PQKBTitleCode)TC0000232124 035 $a(PQKBWorkID)10209987 035 $a(PQKB)10001267 035 $a(MiAaPQ)EBC3376152 035 $a(Au-PeEL)EBL3376152 035 $a(CaPaEBR)ebr10055146 035 $a(CaONFJC)MIL21104 035 $a(OCoLC)923260974 035 $a(Perlego)4733809 035 $a(BIP)1327007 035 $a(EXLCZ)99110986584751472 100 $a19950314d1995 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRadiation dose reconstruction for epidemiologic uses /$fCommittee on an Assessment of CDC Radiation Studies, Board on Radiation Effects Research, Commission on Life Sciences, National Research Council 205 $a1st ed. 210 $aWashington, DC $cNational Academy Press$d1995 215 $a1 online resource (150 p.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$aPrint version: Staff, National Research Council. Radiation-Dose Reconstruction for Epidemiologic Uses. Washington : National Academies Press, ©1900 9780309050999 320 $aIncludes bibliographical references (p. 93-101) and index. 327 $aRadiation Dose Reconstruction for Epidemiologic Uses -- Copyright -- Preface -- Contents -- Executive Summary -- 1 Background -- 2 Introduction -- ELEMENTS OF DOSE RECONSTRUCTION -- TECHNICAL ASPECTS OF DOSE RECONSTRUCTION -- STRUCTURE OF A SCOPING STUDY -- PUBLIC INVOLVEMENT -- SUMMARY AND RECOMMENDATIONS -- NOTE -- 3 Estimating and Confirming The Source Term -- APPROACH TO SOURCE TERM ANALYSIS -- DATA REQUIREMENTS FOR SOURCE TERM ANALYSIS -- EPISODIC RELEASES -- SOURCES OF INFORMATION -- BIAS AND UNCERTAINTY IN RELEASE ESTIMATES -- GAPS IN RELEASE DATA -- SUMMARY AND RECOMMENDATIONS -- 4 Environmental Pathways -- TRANSPORT OF RADIONUCLIDES AND OTHER CONTAMINANTS -- Direct Releases to the Atmosphere -- Direct Releases to the Hydrosphere -- FURTHER CONSIDERATIONS -- Appropriate Use of Mathematical Models -- Uncertainty Analysis -- SUMMARY AND RECOMMENDATIONS -- 5 Radiation Dose Assessment -- SOURCES OF EXPOSURE -- Ambient Exposure -- Inhalation Exposure -- Ingestion Exposure -- POTENTIAL CONSEQUENCES OF RADIATION EXPOSURE -- PRELIMINARY DOSE ASSESSMENT -- COMPREHENSIVE DOSE ASSESSMENT -- INDIVIDUAL DOSE ASSESSMENT -- UNCERTAINTY -- SUMMARY AND RECOMMENDATIONS -- 6 Biologic Dosimetry and Biologic Markers -- MARKERS OF EXPOSURE AND DOSE -- Cytogenetic Markers -- Genetic or Molecular Markers -- Combined Biologic-Maker Assays -- MARKERS OF EFFECT -- MARKERS OF SUSCEPTIBILITY -- MARKERS IN RETROSPECTIVE DOSIMETRY -- MARKERS IN EPIDEMIOLOGY -- SUMMARY AND RECOMMENDATIONS -- 7 Epidemiologic Considerations -- QUANTITATIVE RISK ASSESSMENT: STRENGTHS AND LIMITATIONS OF EPIDEMIOLOGIC STUDIES -- EPIDEMIOLOGY AND DOSE RECONSTRUCTION -- STUDY DESIGN -- Study Types -- Statistical Power -- Outcomes -- Population Identification and Follow-Up -- Bias and Confounding -- Statistical Analysis -- Uncertainty and Misclassification -- SUMMARY AND RECOMMENDATIONS. 327 $a8 Priority Criteria for Dose Assessment Studies -- BASIC CRITERIA -- DECISION CRITERIA -- FINAL RANKING -- SUMMARY AND RECOMMENDATIONS -- 9 Conclusions -- 10 Literature Cited -- Appendix A Representative Dose Reconstruction Studies -- NEVADA TEST SITE -- CHERNOBYL -- THREE MILE ISLAND -- FERNALD -- HANFORD -- TECHA RIVER -- GOIANIA -- NOTES -- Appendix B Workshop Agenda -- DOSE RECONSTRUCTION FOR EPIDEMIOLOGIC USES AGENDA -- Appendix C Workshop Participants -- KEYNOTE SPEAKERS -- SOURCE TERM ESTIMATION -- ENVIRONMENTAL PATHWAYS -- BIOMARKERS -- RADIATION DOSE ASSESSMENT -- EPIDEMIOLOGY -- Appendix D Glossary -- Index. 330 $aGrowing public concern about releases of radiation into the environment has focused attention on the measurement of exposure of people living near nuclear weapons production facilities or in areas affected by accidental releases of radiation. Radiation-Dose Reconstruction for Epidemiologic Uses responds to the need for criteria for dose reconstruction studies, particularly if the doses are to be useful in epidemiology. This book provides specific and practical recommendations for whether, when, and how studies should be conducted, with an emphasis on public participation. Based on the expertise of scientists involved in dozens of dose reconstruction projects, this volume Provides an overview of the basic requirements and technical aspects of dose reconstruction. Presents lessons to be learned from dose reconstructions after Chernobyl, Three Mile Island, and elsewhere. Explores the potential benefits and limitations of biological markers. Discusses how to establish the "source term"--that is, to determine what was released. Explores methods for identifying the environmental pathways by which radiation reaches the body. Offers details on three major categories of dose assessment. 606 $aRadiation injuries$xEpidemiology$xStatistical methods 606 $aRadiation dosimetry 606 $aRadiation Injuries$xepidemiology 606 $aDose-Response Relationship, Radiation 606 $aRadioactive Hazard Release 606 $aRadiometry 615 0$aRadiation injuries$xEpidemiology$xStatistical methods. 615 0$aRadiation dosimetry. 615 12$aRadiation Injuries$xepidemiology. 615 22$aDose-Response Relationship, Radiation. 615 22$aRadioactive Hazard Release. 615 2$aRadiometry. 676 $a616.9/897 712 02$aNational Research Council (U.S.).$bCommittee on an Assessment of CDC Radiation Studies. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910961798603321 996 $aRadiation dose reconstruction for epidemiologic uses$94347771 997 $aUNINA