LEADER 06282nam 2200889Ia 450 001 9910961761803321 005 20251017110102.0 010 $a9786610185993 010 $a9780309173193 010 $a0309173191 010 $a9781280185991 010 $a1280185996 010 $a9780309596985 010 $a030959698X 010 $a9780585068008 010 $a0585068003 035 $a(CKB)110986584752654 035 $a(OCoLC)70772784 035 $a(CaPaEBR)ebrary10056956 035 $a(SSID)ssj0000106767 035 $a(PQKBManifestationID)11128707 035 $a(PQKBTitleCode)TC0000106767 035 $a(PQKBWorkID)10110645 035 $a(PQKB)10667702 035 $a(MiAaPQ)EBC3376680 035 $a(Au-PeEL)EBL3376680 035 $a(CaPaEBR)ebr10056956 035 $a(CaONFJC)MIL18599 035 $a(OCoLC)923265549 035 $a(Perlego)4734061 035 $a(DNLM)899692 035 $a(BIP)48518519 035 $a(EXLCZ)99110986584752654 100 $a19990524d1999 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAssessment of future scientific needs for live variola virus /$fCommittee on the Assessment of Future Scientific Needs for Live Variola Virus, Board on Global Health, Institute of Medicine 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1999 215 $a1 online resource (126 pages) $cillustrations 225 1 $aThe compass series 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$aPrint version: Staff, Institute of Medicine. Assessment of Future Scientific Needs for Live Variola Virus. Washington : National Academies Press, ©1900 9780309064415 311 0 $a9780309064415 311 0 $a0309064414 320 $aIncludes bibliographical references (p. 87-91). 327 $aAssessment of Future Scientific Needs for Live Variola Virus -- Copyright -- Preface -- Acknowledgments -- REVIEWERS -- Contents -- Executive Summary -- SCOPE -- SCIENTIFIC NEEDS FOR LIVE AND REPLICATION-DEFECTIVE VARIOLA VIRUS -- OVERALL CONCLUSIONS -- Part I Introduction -- 1 Introduction -- BACKGROUND -- CONTEMPORARY CONTEXT -- SCOPE -- SCIENTIFIC NEEDS FOR VARIOLA VIRUS -- ORGANIZATION OF THIS REPORT -- Part II Smallpox and Its Control -- 2 Variola Virus and Other Orthopoxviruses -- GENERAL ATTRIBUTES OF ORTHOPOXVIRUSES -- POXVIRUS REPLICATION -- PROPERTIES OF SPECIFIC ORTHOPOXVIRUSES -- 3 Clinical Features of Smallpox -- ENTRY AND INFECTION -- DISSEMINATION -- THE RASH -- LESIONS OF THE MUCOUS MEMBRANES -- EFFECTS ON OTHER ORGANS -- IMMUNE RESPONSE -- IMMUNITY AGAINST SMALLPOX -- 4 Epidemiology -- CHARACTERISTICS OF HISTORICAL OUTBREAKS -- LIKELY CHARACTERISTICS OF FUTURE SMALLPOX OUTBREAKS -- CONTROL STRATEGIES -- 5 Variola Virus Stocks Following Eradication of Smallpox -- ESTABLISHMENT OF INTERNATIONAL REPOSITORIES -- DECISION BY THE WORLD HEALTH ASSEMBLY TO DESTROY VARIOLA VIRUS STOCKS -- U.S. RESEARCH ON SMALLPOX -- RESEARCH AT CDC AND USAMRIID -- Part III Scientific Needs for Variola Virus -- 6 Development of Antiviral Agents -- IN VITRO ASSAYS -- ANIMAL MODELS -- 7 Development of Vaccines -- CURRENT STATUS OF VACCINIA VACCINE PREPARATIONS -- EVALUATION OF VACCINIA VACCINE DERIVED FROM TISSUE CULTURE -- EVALUATION OF NOVEL VACCINES -- 8 Detection and Diagnosis -- ENVIRONMENTAL DETECTION -- DIAGNOSIS OF INFECTION -- ALTERNATIVES TO LIVE VIRUS -- 9 Bioinformatics -- VARIABILITY OF VARIOLA VIRUS -- POTENTIAL DEVELOPMENTS -- 10 Understanding of the Biology of Variola Virus -- VIRUS-CELL INTERACTIONS -- VIRUS-HOST INTERACTIONS -- 11 Research on the Expressed Protein Products of Variola -- SYNTHESIS OF VARIOLA PROTEINS. 327 $aPOTENTIAL UTILITY OF VARIOLA PROTEINS -- Part IV Findings -- 12 Summary and Conclusions -- THE BROADER CONTEXT -- SCIENTIFIC NEEDS FOR LIVE VARIOLA VIRUS -- OVERALL CONCLUSIONS -- References -- Appendix A Glossary -- Appendix B Acronyms -- Appendix C Committee and Staff Biographies -- Staff. 330 $aIn 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus , which examines: -- Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. -- What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. -- What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases. 410 0$aCompass series (Washington, D.C.) 517 3 $aLive variola virus 606 $aSmallpox$xResearch 606 $aSmallpox$xPrevention 606 $aSmallpox vaccine 606 $aVirology$xCultures and culture media 606 $aVariola virus 606 $aSmallpox$xprevention & control 606 $aContainment of Biohazards 615 0$aSmallpox$xResearch. 615 0$aSmallpox$xPrevention. 615 0$aSmallpox vaccine. 615 0$aVirology$xCultures and culture media. 615 12$aVariola virus. 615 22$aSmallpox$xprevention & control. 615 22$aContainment of Biohazards. 676 $a616.9/12 712 02$aInstitute of Medicine (U.S.).$bCommittee on the Assessment of Future Scientific Needs for Live Variola Virus. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910961761803321 996 $aAssessment of future scientific needs for live variola virus$94364157 997 $aUNINA