LEADER 06028nam 2200829Ia 450 001 9910961410503321 005 20250618214919.0 010 $a1-281-79561-5 010 $a9786611795610 010 $a0-08-053355-8 035 $a(CKB)1000000000384820 035 $a(EBL)404398 035 $a(OCoLC)476218302 035 $a(SSID)ssj0000167097 035 $a(PQKBManifestationID)12022874 035 $a(PQKBTitleCode)TC0000167097 035 $a(PQKBWorkID)10168873 035 $a(PQKB)10257774 035 $a(MiAaPQ)EBC404398 035 $a(Au-PeEL)EBL404398 035 $a(CaPaEBR)ebr10251175 035 $a(CaONFJC)MIL179561 035 $a(EXLCZ)991000000000384820 100 $a19990720d1999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHandbook of animal models of infection $eexperimental models in antimicrobial chemotherapy /$fedited by Oto Zak, Merle Sande 205 $a1st ed. 210 $aSan Diego, CA $cAcademic Press$dc1999 215 $a1 online resource (1169 p.) 300 $aDescription based upon print version of record. 311 1 $a0-12-775390-7 311 1 $a9780127753904 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Handbook of Animal Models of Infection; Copyright Page; Contents; List of Section Editors; List of Contributors; Preface; Introduction: The Role of Animal Models in the Evaluation of New Antibodies; Section I: INTRODUCTORY BACKGROUND TO ANIMAL MODELS OF INFECTION; Chapter 1. Early History of Animal Models of Infection; Chapter 2. General Methodologies for Animal Models; Chapter 3. Ethics Committees in Europe-An Overview; Chapter 4. Animal Care and Use Committees-An American Perspective; Chapter 5. Ethical Aspects of the Use of Animal Models of Infection 327 $aChapter 6. The Impact of General Laboratory Animal Health on Experimental Models in Antimicrobial ChemotherapyChapter 7. Non-invasive Monitoring of Infection and Gene Expression in Living Animal Models; Chapter 8. Considerations for Working Safely with Infectious Disease Agents in Research Agents; Chapter 9. Analysis of Genetic Susceptibility to Infection in Mice; Chapter 10. Formulation of Compounds and Determination of Pharmacokinetic Parameters; Chapter 11. Methods for Obtaining Human-like Pharmacokinetic Patterns in Experimental Animals 327 $aChapter 12. Modes of Action of Antibiotics and Bacterial Structure: Bacterial Mass Versus their NumbersChapter 13. Activity of Antibiotics Against Adherent/Slow-growing Bacteria Reflecting the Situation in vivo; Section II: BACTERIAL INFECTION MODELS; Chapter 14. The Mouse Peritonitis/Sepsis Model; Chapter 15. Murine Thigh Infection Model; Chapter 16. Mouse Subcutaneous Cotton Thread Model; Chapter 17. Infection after Ionizing Radiation; Chapter 18. Intra-abdominal Abscess; Chapter 19. Mouse Peritonitis Model Using Cecal Ligation and Puncture 327 $aChapter 20. Murine Models of Peritonitis Involving a Foreign BodyChapter 21. Rat Polymicrobial Peritonitis Infection Model; Chapter 22. Murine Thigh Suture Model; Chapter 23. Animal Models of Melioidosis; Chapter 24. Low Inoculum Model of Clean Wound Infection; Chapter 25. Translocation of Gut Bacteria During Trauma; Chapter 26. Mouse Models of Campylobacter jejuni Infection; Chapter 27. Suckling Mouse Model of Enterotoxigenic Escherickia coli Infection; Chapter 28. Rabbit Model of Shigellosis; Chapter 29. RITARD Rabbit Model for Studying Vibrio cholerae and Other Enteric Infections 327 $aChapter 30. Mouse Model of Helicobacter priori InfectionChapter 31. Animal Models of Helicobacter (ferrets); Chapter 32. Hamster Model of Syphilis; Chapter 33. Guinea-pig Model of Acquired and Congenital Syphilis; Chapter 34. The Guinea-pig Model of Legionnaires Disease; Chapter 35. Murine Models of Tuberculosis; Chapter 36. Beige Mouse Model of Disseminated Mycobacterium avium Complex Infection; Chapter 37. The Armadillo Leprosy Model, with Particular Reference to Lepromatous Neuritis; Chapter 38. Models of Leprosy Infection in Mice; Chapter 39. Hamster Model of Lyme Arthritis 327 $aChapter 40. Rabbit Model of Bacterial Conjunctivitis 330 $aHandbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo