LEADER 06680nam 22007574a 450 001 9910961002203321 005 20251116141112.0 010 $a0-309-18354-5 010 $a1-280-18513-9 010 $a9786610185139 010 $a0-309-56508-1 035 $a(CKB)110986584753258 035 $a(EBL)3377264 035 $a(SSID)ssj0000097020 035 $a(PQKBManifestationID)11128052 035 $a(PQKBTitleCode)TC0000097020 035 $a(PQKBWorkID)10103929 035 $a(PQKB)10240149 035 $a(MiAaPQ)EBC3377264 035 $a(Au-PeEL)EBL3377264 035 $a(CaPaEBR)ebr10068511 035 $a(OCoLC)923269359 035 $a(BIP)53858255 035 $a(BIP)7049157 035 $a(EXLCZ)99110986584753258 100 $a20070309d2000 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAcute exposure guideline levels for selected airborne chemicals /$fSubcommittee on Acute Exposure Guideline Levels, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission of Life Sciences, National Research Council 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$dc2000 215 $a1 online resource (219 p.) 225 1 $aThe compass series 300 $aDescription based upon print version of record. 311 08$a0-309-07294-8 320 $aIncludes bibliographical references. 327 $a""Acute Exposure Guideline Levels for Selected Airborne Chemicals""; ""Copyright""; ""Preface""; ""Contents""; ""Acute Exposure Guideline Levels for Selected Airborne Chemicals""; ""Introduction""; ""SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING AEGLS""; ""REVIEW OF AEGL REPORTS""; ""REFERENCES""; ""Roster of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances""; ""COMMITTEE MEMBERS""; ""OAK RIDGE NATIONAL LABORATORY STAFF""; ""NATIONAL ADVISORY COMMITTEE STAFF""; ""Appendix""; ""1 Aniline1 Acute Exposure Guideline Levels""; ""SUMMARY"" 327 $a""1. INTRODUCTION""""2. HUMAN TOXICITY DATA""; ""2.1. Acute Lethality""; ""2.2. Nonlethal Toxicity""; ""2.2.1. Experimental Studies""; ""2.2.2. Epidemiology Studies""; ""2.2.3. Accidents""; ""2.3. Developmental and Reproductive Effects""; ""2.4. Genotoxicity""; ""2.5. Carcinogenicity""; ""2.6. Summary""; ""3. ANIMAL TOXICITY DATA""; ""3.1. Acute Lethality""; ""3.1.1. Rats""; ""3.1.2. Mice""; ""3.2. Nonlethal Toxicity""; ""3.2.1. Dogs""; ""3.2.2. Rats""; ""3.2.3. Mice""; ""3.2.4 Guinea pigs""; ""3.3. Developmental and Reproductive Effects""; ""3.4. Genotoxicity""; ""3.5. Carcinogenicity"" 327 $a""3.6. Summary""""4. SPECIAL CONSIDERATIONS""; ""4.1. Metabolism and Disposition""; ""4.2. Mechanism of Toxicity""; ""4.3. Structure-Activity Relationships""; ""4.4. Other Relevant Information""; ""4.4.1. Susceptible Subpopulations""; ""4.4.2. Species Differences""; ""4.4.3. Concentration-Exposure Duration Relationship""; ""5. DATA ANALYSIS FOR AEGL-1""; ""5.1. Human Data Relevant to AEGL-1""; ""5.2. Animal Data Relevant to AEGL-1""; ""5.3. Derivation of AEGL-1""; ""6. DATA ANALYSIS FOR AEGL-2""; ""6.1. Human Data Relevant to AEGL-2""; ""6.2. Animal Data Relevant to AEGL-2"" 327 $a""6.3. Derivation of AEGL-2""""7. DATA ANALYSIS FOR AEGL-3""; ""7.1. Human Data Relevant to AEGL-3""; ""7.2. Animal Data Relevant to AEGL-3""; ""7.3. Derivation of AEGL-3""; ""8. SUMMARY OF AEGLS""; ""8.1. AEGL Values and Toxicity Endpoints""; ""8.2. Comparisons with Other Standards and Guidelines""; ""8.3. Data Adequacy and Research Needs""; ""9. REFERENCES""; ""2 Arsine1 Acute Exposure Guideline Levels""; ""SUMMARY""; ""1. INTRODUCTION""; ""2. HUMAN TOXICITY DATA""; ""2.1. Acute Lethality""; ""2.1.1. Case Reports""; ""2.2. Nonlethal Toxicity""; ""2.2.1. Case Reports"" 327 $a""2.2.2. Epidemiologic Studies""""2.3. Developmental and Reproductive Toxicity""; ""2.4. Genotoxicity""; ""2.5. Carcinogenicity""; ""2.6. Summary""; ""3. ANIMAL TOXICITY DATA""; ""3.1. Acute Lethality""; ""3.1.1. Nonhuman Primates""; ""3.1.2. Dogs""; ""3.1.3. Cats""; ""3.1.4 Rats""; ""3.1.5. Mice""; ""3.2. Nonlethal Toxicity""; ""3.2.1. Nonhuman Primates""; ""3.2.2. Rats""; ""3.2.3. Mice""; ""3.2.4. Hamsters""; ""3.3. Developmental/Reproductive Toxicity""; ""3.3.1. Rats""; ""3.3.2. Mice""; ""3.4. Genotoxicity""; ""3.5. Carcinogenicity""; ""3.6. Summary""; ""4. SPECIAL CONSIDERATIONS"" 327 $a""4.1. Metabolism and Disposition"" 330 $aIn the Bhopal disaster of 1984, approximately 2,000 residents living near a chemical plant were killed and 20,000 more suffered irreversible damage to their eyes and lungs following the accidental release of methyl isocyanate. This tragedy served to focus international attention on the need for governments to identify hazardous substances and assist local communities in planning how to deal with emergency exposures. Since 1986, the U.S. Environmental Protection Agency has been tasked with identifying extremely hazardous substances and, in cooperation with the Federal Emergency Management Agency and the Department of Transportation, assist local emergency response planners. The National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances was established in 1995 to develop acute exposure guideline levels (AEGLs) for high priority toxic chemicals that could be released into the air from accidents at chemical plants, storage sites, or during transportation. This book reviews toxicity documents on five chemicals-chlorine, hydrogen chloride, hydrogen fluoride, toluene, and uranium hexafluoride-for their scientific validity, comprehensives, internal consistency, and conformance to the 1993 guidelines report. 410 0$aCompass series (Washington, D.C.) 606 $aGases, Asphyxiating and poisonous 606 $aHazardous substances$xEnvironmental aspects 606 $aHazardous substances$xHealth aspects 606 $aChemicals$xPhysiological effect 606 $aChemicals$xHealth aspects 615 0$aGases, Asphyxiating and poisonous. 615 0$aHazardous substances$xEnvironmental aspects. 615 0$aHazardous substances$xHealth aspects. 615 0$aChemicals$xPhysiological effect. 615 0$aChemicals$xHealth aspects. 676 $a615.9/1 712 02$aNational Research Council (U.S.).$bSubcommittee on Acute Exposure Guideline Levels. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910961002203321 996 $aAcute exposure guideline levels for selected airborne chemicals$92610632 997 $aUNINA