LEADER 05256nam 2200649Ia 450 001 9910784650603321 005 20230120004734.0 010 $a1-281-03719-2 010 $a9786611037192 010 $a0-08-054618-8 035 $a(CKB)1000000000364135 035 $a(EBL)299463 035 $a(OCoLC)476077351 035 $a(SSID)ssj0000204935 035 $a(PQKBManifestationID)11171147 035 $a(PQKBTitleCode)TC0000204935 035 $a(PQKBWorkID)10189761 035 $a(PQKB)11305202 035 $a(MiAaPQ)EBC299463 035 $a(Au-PeEL)EBL299463 035 $a(CaPaEBR)ebr10186787 035 $a(CaONFJC)MIL103719 035 $a(EXLCZ)991000000000364135 100 $a20070628d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular neurology$b[electronic resource] /$fStephen Waxman 210 $aBurlington, MA $cElsevier Academic Press$dc2007 215 $a1 online resource (597 p.) 300 $aDescription based upon print version of record. 311 $a0-12-369509-0 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Molecular Neurology; Copyright Page; Contents; Contributor's List; Preface; Section I: Principles of Molecular Neurology; Chapter 1: Genetics as a Tool in Neurology; I. Introduction; II. Structure and Function of Genes and Chromosomes; III. Genetic Medicine; IV. The Neurogenetic Evaluation; V. Identification of Human Disease Genes; VI. Methods for Human Molecular Genetic Analysis; VII. Treatment of Genetic Diseases; References; Chapter 2: Neurology and Genomic Medicine; I. Introduction; II. Basic Concepts; III. The Human Genome Project (HGP) and Haplotype Mapping (HapMap) Project 327 $aIV. Family HistoryV. Genetic Mechanisms; VI. Pharmacogenetics; VII. Gene-Gene and Gene-Environment Interactions; VIII. Comparative Genomic Hybridization (CGH); IX. Mitochondria and the Mitochondrial Genome (mtDNA); X. Summary; References; Chapter 3: Mitochondrial Function and Dysfunction in the Nervous System; I. Introduction; II. Structure and Functions of Mitochondria; III. Mitochondria in Mechanisms of Neuronal Cell Death and Neurological Disease; IV. Roles of Mitochondrial Dysfunction in Common Neurodegenerative Diseases; V. Conclusions; References 327 $aCahpter 4: Neuronal Channels and ReceptorsI. Introduction; II. Nomenclature; III. Structure and Function; IV. Physiological Roles; V. Neurological Disorders Caused by Channelopathies; References; Chapter 5: Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System; I. Introduction; II. Role of Molecular Chaperones in Protein Folding Quality Control; III. Regulation of Chaperone Expression: The Heat Shock Response; IV. Role of Molecular Chaperones in Neurodegenerative Diseases; V. Chaperone Hypotheses; VI. Therapeutic Avenues; References 327 $aChapter 6: Metabolic Biopsy of the BrainI. Phosphorus Magnetic Resonance Spectroscopy; II. The Phosphocreatine Shuttle Hypothesis; III. Magnetization Transfer Measurements of ATP and Phosphocreatine Synthesis; IV. Hydrogen (Proton) Spectroscopy; V. Carbon Spectroscopy; VI. MR Spectroscopic Measurements of Cerebral Lactate; VII. The Astrocyte-Neuron Lactate Shuttle Hypothesis; VIII. Cerebral Ammonia Metabolism; IX. Summary; References; Chapter 7: Gene Therapy Approaches in Neurology; I. Why Use Gene Transfer in the Development of Novel Therapies?; II. Gene Transfer Strategies 327 $aIII. Development of Neurological Gene TherapyIV. Conclusions-Future Developments; References; Chapter 8: Programmed Cell Death and Its Role in Neurological Disease; I. Introduction: Neurologists and Cell Death; II. Cell Death: History and Classification; III. Current Status of Programmed Cell Death Studies; IV. Trophic Factors and the Concept of Cellular Dependence; V. Apoptosis Induced by Unfolded, Misfolded, or Alternatively Folded Proteins; VI. Does Programmed Cell Death Play a Role in Neurodegeneration? 327 $aVII. Are Programmed Cell Death Pathways Appropriate Therapeutic Targets in Neurodegeneration? 330 $aWhy a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. This book highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlyin 606 $aMolecular neurobiology 606 $aMolecular biology 615 0$aMolecular neurobiology. 615 0$aMolecular biology. 676 $a573.84 676 $a616.8 700 $aWaxman$b Stephen G$0628462 701 $aWaxman$b Stephen G$0628462 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784650603321 996 $aMolecular neurology$93722172 997 $aUNINA LEADER 06009nam 22007095 450 001 9910960204703321 005 20220126121916.0 010 $a9789460918759 010 $a9460918751 010 $a9789460918766 010 $a946091876X 024 7 $a10.1007/978-94-6091-876-6 035 $a(CKB)2550000001102459 035 $a(EBL)3034713 035 $a(SSID)ssj0000849983 035 $a(PQKBManifestationID)12427492 035 $a(PQKBTitleCode)TC0000849983 035 $a(PQKBWorkID)10825219 035 $a(PQKB)11651978 035 $a(DE-He213)978-94-6091-876-6 035 $a(MiAaPQ)EBC3034713 035 $a(OCoLC)810077648 035 $a(nllekb)BRILL9789460918766 035 $a(MiAaPQ)EBC1083763 035 $a(Au-PeEL)EBL3034713 035 $a(CaPaEBR)ebr10602385 035 $a(Au-PeEL)EBL1083763 035 $a(CaONFJC)MIL422087 035 $a(OCoLC)827212301 035 $a(PPN)168342871 035 $a(EXLCZ)992550000001102459 100 $a20120906d2012 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHealth Education in Context: An International Perspective on Health Education in Schools and Local Communities /$fedited by Neil Taylor, Frances Quinn, Michael Littledyke, Richard K. Coll 205 $a1st ed. 2012. 210 1$aRotterdam :$cSensePublishers :$cImprint: SensePublishers,$d2012. 215 $a1 online resource (262 p.) 300 $aDescription based upon print version of record. 311 08$a9789460918742 311 08$a9460918743 311 08$a9781283908375 311 08$a1283908379 320 $aIncludes bibliographical references. 327 $aPreliminary Material /$rNeil Taylor , Frances Quinn , Michael Littledyke and Richard K. Coll -- Health education in context /$rNeil Taylor , Frances Quinn , Michael Littledyke and Richard K. Coll -- Whole school approaches to health promotion /$rSereana Tagivakatini and Temo K. Waqanivalu -- Health education in the Sultanate of Oman /$rAbdullah Ambusaidi and Sulaiman Al-Balushi -- Health education through extracurricular activities in Lebanon /$rMayada Kanj -- Health education in Portuguese schools /$rGraça S. Carvalho -- The possibility of health education in an education-based society /$rMagdolna Chrappán -- An overview of formal and non-formal health education in Turkey /$rMuammer Çalik and Gamze Çan -- Education for healthy lifestyles in the European north of Russia /$rMarina Gvozdeva and Valentina Kirilina -- The role of education in preventing diseases /$rJoost Platje and Krystyna S?odczyk -- Lifting the lid on HIV/AIDS and tuberculosis in Malawi /$rGilbert R. Phiri -- Medical research in South Africa /$rFrancesca Conradie -- The development of the school health policy and curriculum in Nigeria /$rOlawale A. Moronkola -- The child-to-child curriculum in East Africa (Kenya and Tanzania) /$rHenry Sammy Wanyama and Kalafunja Mlang`a O-saki -- Health education in Ethiopia /$rFrehiwot Wubshet and Temechegn Engida -- The status of health education in Namibian schools /$rChoshi D. Kasanda , Maria Charlotte Keyter and Donovan Zealand -- Environmental problems and their impact on people?s health /$rJosiah O. Ajiboye and Folashade Afolabi -- Promoting healthy ageing /$rWendy R. Holmes and Jennifer Joseph -- Educating Indian children about the impact of climate change on health /$rShyamala Mani , D. K. Banerjee , Divya Pant , Priyanka Porwal and Shefali Godura -- Health education in primary schools in Pakistan /$rSadia Muzaffar Bhutta -- Health and sex education in India /$rMala Sharda and Mike Watts -- Malaysian traditional knowledge and herbal gardens /$rNoor Azlin Yahya and Nor Azah Mohd. Ali -- Supporting health education in Thai contexts /$rTussatrin Kruatong and Chanyah Dahsah -- Priorities for health education in Hong Kong in relation to non-communicable diseases /$rEmmy Man Yee Wong and May May Hung Cheng -- Working towards a healthier Brunei /$rIrene Poh-Ai Cheong -- Integration of Health Education for Sustainable Development /$rMohd. Zaki Ishak and Hamzah Md. Omar -- Mental health education and training in Vietnam /$rHoang-Minh Dang and Bahr Weiss -- Health education in China (1978?2010) /$rYimin Wang -- The influence of context on health education /$rNeil Taylor , Frances Quinn , Michael Littledyke and Richard K. Coll. 330 $aThis book presents an international perspective on health education and specifically the influence that context has on this aspect of education. The focus includes both formal and non-formal health education and the factors that impact upon its effectiveness, particularly in non-Western and non-English-speaking contexts (i.e., outside the UK, USA, Australia, NZ, etc.). An important feature of the book is that it draws upon the experiences and research of local experts, representing the perspectives of an extremely diverse cohort across the world (22 countries and 2 regions in total). The book addresses topics such as: the development and implementation of health education in different countries; the influence of political, cultural, societal or religious mores; governmental or ministerial drives; economic or other pressures driving curriculum reform; and the influence of external assessment regimes on health education. By embedding discussions of health education in local contexts and representing a diversity of perspectives on this important topic this book highlights both barriers and enablers to improving health education across the globe. 606 $aEducation 606 $aEducation 615 0$aEducation. 615 14$aEducation. 676 $a370 701 $aTaylor$b Neil$0291783 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910960204703321 996 $aHealth Education in Context: An International Perspective on Health Education in Schools and Local Communities$94333269 997 $aUNINA