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100   $a20031222d2004      uy         0
101 0 $aeng
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181   $ctxt
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200 10$aAdvancing prion science $eguidance for the national prion research program /$fCommittee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science ; Rick Erdtmann and Laura B. Sivitz, editors
205   $a1st ed.
210   $aWashington, DC $cNational Academies Press$dc2004
215   $a1 online resource (288 p.)
300   $aBibliographic Level Mode of Issuance: Monograph
311 08$a9780309090605 
311 08$a0309090601 
320   $aIncludes bibliographical references.
327   $aExecutive summary -- Prion diseases: an overview -- Diagnostics for transmissible spongiform encephalopathies -- Testing blood for evidence of transmissible spongiform encephalopathies in the United States -- Assessment of strategies to prevent and treat transmissible spongiform encephalopathies -- Infrastructure for research on transmissible spongiform encephalopathies -- Risks of transmissible spongiform encephalopathies to the U.S. military.
330   $aIn Advancing Prion Science , the Institute of Medicine (TM)s Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense (TM)s National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions (TM) normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs "from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.
606   $aPrion diseases
606   $aPrion diseases$xGovernment policy$zUnited States
606   $aMedical policy
606   $aPrion Diseases$xprevention & control
606   $aPrion Diseases$xdiagnosis
606   $aFood Supply$xstandards
606   $aHealth Policy
607   $aUnited States
615  0$aPrion diseases.
615  0$aPrion diseases$xGovernment policy
615  0$aMedical policy.
615  2$aPrion Diseases$xprevention & control.
615  2$aPrion Diseases$xdiagnosis.
615  2$aFood Supply$xstandards.
615  2$aHealth Policy.
676   $a616.8/3
701   $aErdtmann$b Rick$01790846
701   $aSivitz$b Laura$01790847
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910960200203321
996   $aAdvancing prion science$94327595
997   $aUNINA