LEADER 05640nam 2200601 a 450 001 9910959970903321 005 20251116181818.0 010 $a1-62081-340-8 035 $a(CKB)2550000001043056 035 $a(EBL)3021144 035 $a(SSID)ssj0001035409 035 $a(PQKBManifestationID)11596973 035 $a(PQKBTitleCode)TC0001035409 035 $a(PQKBWorkID)11028816 035 $a(PQKB)11383694 035 $a(MiAaPQ)EBC3021144 035 $a(Au-PeEL)EBL3021144 035 $a(CaPaEBR)ebr10681344 035 $a(OCoLC)832756287 035 $a(BIP)39238730 035 $a(EXLCZ)992550000001043056 100 $a20130408d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aOsteoclasts $emorphology, functions and clinical implications /$fAlexander J. Brown and Johanna S. Walker, editors 205 $a1st ed. 210 $aNew York $cNova Science Publishers, Inc.$d2012 215 $a1 online resource (182 p.) 225 1 $aCell biology research progress 225 1 $aHuman anatomy and physiology 300 $aDescription based upon print version of record. 311 08$a1-62081-306-8 320 $aIncludes bibliographical references and index. 327 $aIntro -- OSTEOCLASTS -- OSTEOCLASTS -- Contents -- Preface -- Modulation of Osteoclast Differentiation and Function in Rheumatoid Arthritis -- Introduction -- Osteoclasts in Rheumatoid Arthritis -- Growth Factors -- Macrophage Colony Stimulating Factor -- Granulocyte Macrophage- Colony Stimulating Factor -- Transforming Growth Factor-Beta -- Tumor Necrosis Factor Super Family -- Receptor Activator of NF-Kappa B Ligand -- Tumor Necrosis Factor-Alpha -- Osteoprotegerin -- Interferon Family -- Interleukin Family -- Interleukin 1 -- Interleukin 6 -- Interleukin 10 -- Conclusion -- Refrences -- Osteoclast Formation and Function and Its role in Skeletal Bone Disease -- Abstract -- Introduction -- Multinucleation -- Sealing Zone -- Ruffled Border -- Basolateral Membrane -- OCs and Clinical Implications -- Osteopetrosis -- Pycnodysostosis -- Paget's Disease -- Osteoporosis -- Cancer -- Inflammatory Arthritis -- Conclusion -- Acknowledgments -- References -- The High Osteoclastogenic Potential of Human Osteosarcoma Cells: Reciprocal Interaction between MG63 Osteoblast-Like Cells and Osteoclast Precursors -- Abstract -- 1. Introduction -- 2. Cell Culture Models -- 2.1. MG63 Cell Line -- 2.2. Peripheral Blood Mononuclear Cells (PBMC) -- 3. Osteoclastogenic Potential of the MG63 -- Cell Line -- 3.1. Paracrine-Mediated Mechanisms -- 3.2. Cell-to-Cell Contact Mechanisms -- 4. Modulation of the MG63 Cell Behavior by Osteoclastic Cells -- Conclusion -- References -- Osteoclast Biology in Paget's Disease of Bone -- Abstract -- Osteoclast Phenotype in PDB -- Viral and Genetic Factors in Paget's Disease of Bone -- Role of p62 in Osteoclast Signaling -- p62 as a Shuttling Factor -- Role of p62 Mutations in Paget's Disease of Bone -- Conclusion -- References -- Osteoclasts: The Major Actors in Bone Resorption -- Abstract -- Introduction. 327 $aOsteoclast Differentiation and Activation -- Osteoclasts and Immune System Talk -- Osteoclasts in Bone Metastases -- Osteoclasts in Rheumatoid Arthritis -- Osteoclasts in Periprosthetic Osteolysis -- Osteoclasts in Pedriatic Disease -- Osteoclasts in Osteoporosis -- Conclusion -- References -- Role of the Immuno-Skeletal Interface in Physiological and Pathological Osteoclast Regulation -- Abstract -- Introduction -- 1. Physiological Osteoclast Formation and the Role of the RANK/RANKL/OPG Axis -- 2. Role of the Immuno-skeletal Interface in Physiological Osteoclast Renewal -- a) T Cells and B Cells, the Centerpiece of Cell-mediated Immunity -- b) T Cells and B Cells, Critical Regulators of Basal Osteoclastogenesis -- c) Disruption of the Immuno-skeletal Interface and Bone Loss Associated with HIV-Infection -- d) The immuno-skeletal Interface and Osteoclastic Bone Loss Associated with inflammatory Disease -- e) Role of the Immuno-skeletal interface in Estrogen Deficiency-induced Bone Loss -- Conclusion -- Acknowledgments -- References -- Multiple Functions of Osteoclasts and Potential Usefulness of Phosphatidylserine-Containing Liposomes on Bone Diseases -- Abstract -- Introduction -- Immune Fuctions of OCs -- Angiogenic Functions of OCs -- HSC Regulation Function of OCs -- Effects of PSLs on OCs -- Effects of PSLs on Macrophages/Miroglia -- Effects of PSLs on DCs -- Conclusion -- References -- Bone Formation and Osteoclastic Resorption after Implantation of beta-Tricalcium Phosphate (beta-TCP) -- Abstract -- Introduction -- Materials and Methods -- Experiment 1 -- Experiment 2 -- Results -- Experiment 1 -- Experiment 2 -- Discussion -- Conclusion -- References -- Osteoclasts of Patients with Neurofibromatosis 1 (NF1) -- Abstract -- Short Communication -- References -- Index. 330 $aIn this book, the authors present current research in the study of the morphology, functions and clinical implications of osteoclasts. Topics include osteoclast formation and function and its risk in skeletal bone disease. 410 0$aCell biology research progress. 410 0$aHuman anatomy and physiology series. 606 $aOsteoclasts 615 0$aOsteoclasts. 676 $a616.71 701 $aBrown$b Alexander J$01864516 701 $aWalker$b Johanna S$01864517 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910959970903321 996 $aOsteoclasts$94471367 997 $aUNINA