LEADER 03184nam 2200601Ia 450 001 9910958583003321 005 20251116221328.0 010 $a1-60741-670-0 035 $a(CKB)2560000000070922 035 $a(EBL)3018523 035 $a(SSID)ssj0000472797 035 $a(PQKBManifestationID)11284032 035 $a(PQKBTitleCode)TC0000472797 035 $a(PQKBWorkID)10434725 035 $a(PQKB)10722638 035 $a(MiAaPQ)EBC3018523 035 $a(BIP)25941637 035 $a(EXLCZ)992560000000070922 100 $a20090228d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe ribonucleotide reductase family $egenetics and genomics /$fEduard Torrents, Margareta Sahlin and Britt-Marie Sjoberg 205 $a1st ed. 210 $aNew York $cNova Biomedical Books$dc2009 215 $a1 online resource (109 p.) 225 0 $aNovinka The ribonucleotide reductase family 300 $aDescription based upon print version of record. 311 08$a1-60692-419-2 320 $aIncludes bibliographical references (p. [65]-87) and index. 327 $aIntro -- THE RIBONUCLEOTIDEREDUCTASE FAMILY:GENETICS AND GENOMICS -- Contents -- Preface -- Introduction -- RNR Classification and Occurrence -- Class I RNRs -- Class II RNRs -- Class III RNRs -- RNR distribution as seen in RNRdb -Ribonucleotide Reductase Database -- Atypical and Unconventional RNRs -- RNR Diversification -- Modularity Hypothesis for RNR ClassDiversificatio -- Regulation of RNRs -- Archaea -- Eubacteria -- Mutational Studies in RNRs -- RNR as an Antiproliferative Targetfor Disease Control -- Substrate Analogues -- Radical Scavengers Attacking the TyrosylRadical -- Iron Chelators -- Peptidomimetics Corresponding to the CTerminusof NrdB -- Manipulating the Expression of RNR -- Other Potential Inhibitors and AllostericNucleotide Analogues -- Future Antiproliferative Regimes -- Acknowledgments -- References -- Index. 330 $aRibonucleotide reductase (RNR), has a central role in DNA replication and repair by catalysing production of deoxyribonucleotides from the corresponding ribonucleotides. The authors describe a comprehensive summary of how the expression of RNR genes is regulated in several eubacterial organisms and in yeast. Due to RNR's importance for the realisation of DNA replication, it has been recognised as a possible target for antiproliferative therapy. The authors present a comprehensive summary of RNR-specific inhibitors that have reached clinical trials and/or are currently used in clinical therapy. 606 $aOxidoreductases 606 $aEnzymes 606 $aGenetics 606 $aGenomics 615 0$aOxidoreductases. 615 0$aEnzymes. 615 0$aGenetics. 615 0$aGenomics. 676 $a572/.791 700 $aTorrents$b Eduard$01866849 701 $aSahlin$b Margareta$01866850 701 $aSjoberg$b Britt-Marie$01866851 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910958583003321 996 $aThe ribonucleotide reductase family$94474314 997 $aUNINA